1,2,3,4-tetrahydronaphthalene-1-acetic acid methyl ester | 79781-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1,2,3,4-tetrahydronaphthalene-1-acetic acid methyl ester
• 英文别名: (1,2,3,4-tetrahydro-[1]naphthyl)-acetic acid methyl ester；(1,2,3,4-Tetrahydro-[1]naphthyl)-essigsaeure-methylester；Methyl 2-(1,2,3,4-tetrahydronaphthalen-1-yl)acetate
• CAS: 79781-33-2
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: VYKXUIQNMSKSGL-UHFFFAOYSA-N

物化性质

• 沸点：
  118-119.5 °C(Press: 1 Torr)
• 密度：
  1.053±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydronaphthalene-1-acetic acid methyl ester 在 lithium aluminium tetrahydride 、 磷酸 、 phosphorus pentoxide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2,3,4,5-tetrahydroacenaphthylen-1-ol
  参考文献：
  名称：

  Mitra, Ashutosh; Ray, Rebati M.; Majumder, Arun K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 6, p. 449 - 452

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 2-cyano-2-(3,4-dihydronaphthalen-1(2H)-ylidene)acetate 在 盐酸 、 potassium cyanide 、 三氯化铝 、 乙酸酐 、 溶剂黄146 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 79.0h， 生成 1,2,3,4-tetrahydronaphthalene-1-acetic acid methyl ester
  参考文献：
  名称：

  Mitra, Ashutosh; Ray, Rebati M.; Majumder, Arun K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 6, p. 449 - 452

  摘要：

  DOI：

文献信息

• Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp³ C−H Bonds under Mild Reaction Conditions
  作者：Yiqing Feng、Yuji Wang、Bradley Landgraf、Shi Liu、Gong Chen

  DOI：10.1021/ol101220x

  日期：2010.8.6

  methylene C−H bond is described. The palladium-catalyzed C−H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature

  描述了一种通过芳基碘化物和亚甲基CH键分子内偶联使苯环环化的实用合成方法。钯催化的CH官能团由氨基喹啉羧酰胺基团控制，该基团易于安装和拆卸。实现了高产量和广泛的基板范围。通过系统筛选确定的邻苯基苯甲酸添加剂可在温和条件下，甚至在室温下，作为催化过程的关键配体。
• The slippery slope of constructivism
  作者：Terry Brumley Northcut、Nina Rovinelli Heller

  DOI：10.1080/00377310209517656

  日期：2002.3

  While constructivism as both a philosophy and a clinical practice is being embraced by many individual and family practitioners, it remains controversial. This paper examines the difficulties one encounters in trying to balance the client's "relative truths" with those around them, including that of the therapist. Through the use of clinical vignettes, the authors demonstrate the difficulties inherent in dealing with ambiguities in the clinical situation, balancing the client's perspective, with that of a predominant culture or biological "fact," and considering the issue of the client's "veracity." Particular attention is paid to the difficulties involved in work with trauma survivors, whose own recollections of events may be ambiguous. Finally, the authors discuss the implications that constructivism holds for research and social action and advocacy. In sum, the authors recognize significant promise in the constructivist perspective, but caution clinicians to consider the inherent difficulties in a theory that relies on the relativity of truth.
• Alder et al., Justus Liebigs Annalen der Chemie, 1959, vol. 627, p. 59,72
  作者：Alder et al.

  DOI：——

  日期：——
• MITRA, ASHUTOSH;RAY, REBATI, M.;MAJUMDER, ARUN, K., INDIAN J. CNHEM., 1981, 20, N 6, 449-452
  作者：MITRA, ASHUTOSH、RAY, REBATI, M.、MAJUMDER, ARUN, K.

  DOI：——

  日期：——