3-amino-2-oxo-1-phenyl-1,2-dihydropyrido[3,2-b]indole | 474642-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-amino-2-oxo-1-phenyl-1,2-dihydropyrido[3,2-b]indole
• 英文别名: Ruvlfarpuzgddk-uhfffaoysa-；3-amino-1-phenyl-5H-pyrido[3,2-b]indol-2-one
• CAS: 474642-19-8
• 化学式: C₁₇H₁₃N₃O
• 分子量: 275.31
• InChiKey: RUVLFARPUZGDDK-UHFFFAOYSA-N

物化性质

• 沸点：
  546.6±50.0 °C(Predicted)
• 密度：
  1.381±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-2-oxo-1-phenyl-1,2-dihydropyrido[3,2-b]indole 在 联苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 ethyl 1-chloro-5-oxo-6-phenyl-6,11-dihydro-5H-indolo[2,3-f][1,7]naphthyridine-2-carboxylate
  参考文献：
  名称：

  Synthesis of derivatives of a new heterocyclic system, indolo[2,3-f][1,7]naphthyridine

  摘要：

  3-(N'-Aryl-N'-cliloroacetyl)amino-2-formyliildoles were converted into 3-amino-1-aryl2-oxo-1,2-dihvdropyrido[3,2-b]indoles, which were used to synthesize derivatives of a new heterocyclic system, namely, indolo [2.3-f][1,7] naphthyridine. The structures of the resulting Compounds were proved by IR and H-1 NMR spectroscopy and mass spectrometry.

  DOI：

  10.1023/b:rucb.0000011871.28637.78
• 作为产物：
  描述：

  2-formyl-3-(N'-chloroacetyl-N'-phenyl)aminoindole 在 苄胺 作用下， 以 甲醇 为溶剂， 反应 51.0h， 生成 3-amino-2-oxo-1-phenyl-1,2-dihydropyrido[3,2-b]indole
  参考文献：
  名称：

  摘要：

  1-Aryl-2-oxo-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole N-oxides were synthesized based on 3-(N'-aryl-N'-chloroacetyl)amino-2-formylindoles. Deoxidation of 2-oxo-1-phenyl-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole N-oxide afforded 1,2,3,6-tetrallydro- and 1,2,3,4,5,6-hexahydro[1,4]diazepino[6,5-b]indole derivatives. A new approach to the synthesis of pyrido[3,2-b]indole and pyrimido[5,4-b]indole derivatives was developed.

  DOI：

  10.1023/a:1015520621450

文献信息

• ——
  作者：N. A. Lantsetti、S. Yu. Ryabova、L. M. Alekseeva、A. S. Shashkov、V. G. Granik

  DOI：10.1023/a:1015520621450

  日期：——

  1-Aryl-2-oxo-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole N-oxides were synthesized based on 3-(N'-aryl-N'-chloroacetyl)amino-2-formylindoles. Deoxidation of 2-oxo-1-phenyl-1,2,3,6-tetrahydro[1,4]diazepino[6,5-b]indole N-oxide afforded 1,2,3,6-tetrallydro- and 1,2,3,4,5,6-hexahydro[1,4]diazepino[6,5-b]indole derivatives. A new approach to the synthesis of pyrido[3,2-b]indole and pyrimido[5,4-b]indole derivatives was developed.
• Synthesis of derivatives of a new heterocyclic system, indolo[2,3-f][1,7]naphthyridine
  作者：N. A. Rastorgueva、S. Yu. Ryabova、E. A. Lisitsa、L. M. Alekseeva、V. G. Granik

  DOI：10.1023/b:rucb.0000011871.28637.78

  日期：2003.10

  3-(N'-Aryl-N'-cliloroacetyl)amino-2-formyliildoles were converted into 3-amino-1-aryl2-oxo-1,2-dihvdropyrido[3,2-b]indoles, which were used to synthesize derivatives of a new heterocyclic system, namely, indolo [2.3-f][1,7] naphthyridine. The structures of the resulting Compounds were proved by IR and H-1 NMR spectroscopy and mass spectrometry.

表征谱图