4,5-dihydroxyphenanthrene | 10127-55-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 4,5-dihydroxyphenanthrene
• 英文别名: 4,5-Phenanthrenediol；phenanthrene-4,5-diol
• CAS: 10127-55-6
• 化学式: C₁₄H₁₀O₂
• mdl: MFCD00028886
• 分子量: 210.232
• InChiKey: TWTDMNQJLRKNLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5-dihydroxyphenanthrene 在 potassium dihydrogenphosphate 、 potassium nitrososulfonate 作用下， 以 丙酮 为溶剂， 生成 5-Hydroxy-1,4-phenanthrenchinon
  参考文献：
  名称：

  Attempted preparation of new phenanthrenequinone types

  摘要：

  DOI：

  10.1021/jo01277a015
• 作为产物：
  描述：

  2,2'-bis(bromomethyl)-6,6'-dimethoxy-1,1'-biphenyl 在 吡啶盐酸盐 、 sulfur 作用下， 生成 4,5-dihydroxyphenanthrene
  参考文献：
  名称：

  Attempted preparation of new phenanthrenequinone types

  摘要：

  DOI：

  10.1021/jo01277a015

文献信息

• Attempted characterisation of phenanthrene-4,5-quinone and electrochemical synthesis of violanthrone-16,17-quinone. How does the stability of bay quinones correlate with structural and electronic parameters?
  作者：Dylan Wilkinson、Giacomo Cioncoloni、Mark D. Symes、Götz Bucher

  DOI：10.1039/d0ra06519f

  日期：——

  provide evidence for the reversible formation of phenanthrene-4,5-quinone. Even at temperatures as low as T = 229 K, cyclic voltammograms did not show any evidence for reversibility, indicating that phenanthrene-4,5-quinone likely is a reactive intermediate even at low temperatures. Electrochemical oxidation of the larger homologue 16,17-dihydroxyviolanthrone, on the other hand, was reversible, and the

  在月桂醌中，两个羰基部分通过它们的空间排列被迫靠近，从而产生有趣的轴向手性和非平面结构。在这项工作中，实验研究了这类很少探索的化合物的两个代表。4,5-二羟基菲的电化学氧化未能为菲-4,5-醌的可逆形成提供证据。即使在温度低至T= 229 K，循环伏安图没有显示任何可逆性的证据，这表明即使在低温下，菲-4,5-醌也可能是一种反应性中间体。另一方面，较大的同系物 16,17-二羟基紫蒽酮的电化学氧化是可逆的，并且可以通过光谱电化学方法表征醌。量子化学计算的结果证实了实验结果，并表明在许多鸟环素抗生素中也发现的湾二羰基部分不一定具有极端反应性。然而，在一系列具有相同数量（零）克拉尔六重体和不同数量的海湾羰基（零到两个）的菲醌中，三重态能量之间存在明显的相关性，作为双自由基特征的量度，
• Novel compounds
  申请人：——

  公开号：US20030092637A1

  公开（公告）日：2003-05-15

  The present invention relates to combinations of xylose compounds with other pharmaceutically active compounds, to pharmaceutical compositions comprising said combinations, as well as to use of these combinations for the manufacture of a medicament for treatment of proliferative disorders. In another aspect, the present invention relates to novel xylose compounds, to pharmaceutical compositions comprising said compounds, and to use of these compounds for the manufacture of a medicament or the treatment of proliferative disorders.

  本发明涉及木糖化合物与其他药用活性化合物的组合物、包含所述组合物的药物组合物，以及使用这些组合物制造治疗增殖性疾病的药物。另一方面，本发明涉及新型木糖化合物、包含上述化合物的药物组合物，以及使用这些化合物制造药物或治疗增殖性疾病。
• Elimination of acetic acid from protonated 4,5-diacetoxyphenanthrene and 2,2′-diacetoxybiphenyl: An example of an ion chemistry proximity effect
  作者：M. Orlando、M. George、M. L. Gross

  DOI：10.1002/oms.1210281033

  日期：1993.10

  AbstractProtonated 4,5‐diacetoxyphenanthrene and 2,2′‐diacetoxybiphenyl dissociate, owing to the interaction of the two acetoxy groups, by eliminating a molecule of acetic acid. This novel proximity effect, which occurs for a fast atom bombardment‐produced closed‐shell ion, was examined in detail using tandem mass spectrometric methods. This process, which was first observed in the decompositions of acetylated complex natural products such as stentorin and hypericin, may serve as a general process for determining the proximity of hydroxyl groups in polycyclic aromatic compounds.
• Oxygen sensitization of electron capture response to isomers of polycyclic aromatic amines and hydroxides
  作者：J. A. Campbell、E. P. Grimsrud、L. R. Hageman

  DOI：10.1021/ac00259a034

  日期：1983.7.1
• METHODS AND SYSTEMS OF GRAFT POLYMERIZATION ON A FUNCTIONALIZED SUBSTRATE
  申请人：Spevacek John A.

  公开号：US20140296366A1

  公开（公告）日：2014-10-02

  Graft polymerization is fullfiled on a functionalized substrate. The functionalized substrate is prepared from a disulfide bond-containing feedstock and has been prepared for polymerization through the introduction of one or more polyfunctional monomers containing a disulfide bond breaking material functional group.