propyl hex-5-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: propyl hex-5-enoate
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: UYEYHLKPRJBMOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  propyl hex-5-enoate 、 9-硼双环[3.3.1]壬烷 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 6-(9-borabicyclo[3.3.1]non-9-yl)-propyl hexanoate
  参考文献：
  名称：

  Stereoselective Synthesis of Rubrenoic and nor‐Rubrenoic acids

  摘要：

  The total stereoselective synthesis of (Z)-rubrenoic I (1a), (Z)-nor-rubrenoic I (17a), (E)-rubrenoic III (3b), and nor-(E)-rubrenoic III (30b) acids was achieved using Suzuki and Stille cross-coupling reactions from readily available starting materials.

  DOI：

  10.1080/00397910701649049
• 作为产物：
  描述：

  5-己烯酸 、 溴丙烷 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以86%的产率得到propyl hex-5-enoate
  参考文献：
  名称：

  Stereoselective Synthesis of Rubrenoic and nor‐Rubrenoic acids

  摘要：

  The total stereoselective synthesis of (Z)-rubrenoic I (1a), (Z)-nor-rubrenoic I (17a), (E)-rubrenoic III (3b), and nor-(E)-rubrenoic III (30b) acids was achieved using Suzuki and Stille cross-coupling reactions from readily available starting materials.

  DOI：

  10.1080/00397910701649049

文献信息

• METHOD FOR PRODUCING HIGH PURITY TERMINAL OLEFIN COMPOUND
  申请人：Miyoshi Kei

  公开号：US20120029229A1

  公开（公告）日：2012-02-02

  An industrially advantageous method for producing a high purity terminal olefin is disclosed, comprising the steps of (a) contacting a mixture comprising a terminal olefin represented by formula (1): and one or more corresponding internal olefins as impurities, with a brominating agent in the presence of water or an alcohol, to convert the internal olefin(s) to compound(s) having a higher boiling point than the terminal olefin; and (b) purifying the terminal olefin by distillation from the reaction mixture.

  本发明公开了一种工业上有利的制备高纯度末端烯烃的方法，包括以下步骤：(a)将一个由式（1）所表示的末端烯烃与一个或多个相应的内部烯烃杂质混合物，在水或醇的存在下与溴化剂接触，将内部烯烃转化为比末端烯烃沸点高的化合物；(b)通过蒸馏从反应混合物中纯化末端烯烃。
• METHOD FOR PRODUCING HIGH-PURITY TERMINAL OLEFIN COMPOUND
  申请人：Kuraray Co., Ltd.

  公开号：EP2415740A1

  公开（公告）日：2012-02-08

  PROBLEM There is provided an industrially advantageous means to obtain a high purity terminal olefin compound (for example, 7-octenal). SOLUTION The method for producing a high purity terminal olefin compound of the present invention comprises a step where a mixture containing a terminal olefin compound represented by the following chemical formula 1: and a corresponding internal olefin compound as an impurity is brought into contact with a brominating agent in the presence of water or an alcohol, to convert the aforementioned internal olefin compound to a compound having a higher boiling point; and a step where the aforementioned terminal olefin compound is purified by distillation from the mixture obtained in the aforementioned step.

  问题 提供了一种获得高纯度末端烯烃化合物（例如 7-辛烯醛）的工业上有利的方法。 解决方案 本发明生产高纯度端基烯烃化合物的方法包括以下步骤：将含有由以下化学式 1.A.表示的端基烯烃化合物的混合物与由以下化学式 2.A.表示的端基烯烃化合物的混合物进行混合，然后将混合物与由以下化学式 3.A.表示的端基烯烃化合物的混合物进行混合： 和作为杂质的相应内部烯烃化合物的混合物，在水或醇的存在下与溴化剂接触，将上述内部烯烃化合物转化为沸点较高的化合物；以及从上述步骤中得到的混合物中通过蒸馏提纯上述末端烯烃化合物的步骤。
• NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES
  申请人：Hegmans Alexander

  公开号：US20130190223A1

  公开（公告）日：2013-07-25

  The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R′, R1 and R2, where R′ is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl.
• CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACID 1 AND 3
  申请人：Hegmans Alexander

  公开号：US20140142033A1

  公开（公告）日：2014-05-22

  Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
• Cyclosporine Analogue Molecules Modified At Amino Acid 1 and 3
  申请人：Ciclofilin Pharmaceuticals Corp.

  公开号：US20160207961A1

  公开（公告）日：2016-07-21

  Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.