tert-butyl 5-tert-butoxycarbonylamino-3-oxopentanoate | 302600-48-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: tert-butyl 5-tert-butoxycarbonylamino-3-oxopentanoate
• 英文别名: Tert-butyl 5-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxopentanoate
• CAS: 302600-48-2
• 化学式: C₁₄H₂₅NO₅
• 分子量: 287.356
• InChiKey: RXUNQHIZXWQRLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 5-tert-butoxycarbonylamino-3-oxopentanoate 在 [,14-bis(diphenylphosphino)butane] (1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以100%的产率得到tert.-butyl 5-tert.-butoxycarbonylamino-3-hydroxypentanoate
  参考文献：
  名称：

  Process for preparing C5 products and their use for Atorvastatin synthesis

  摘要：

  本发明涉及一种制备C5中间体并将其用于制备一类对人类胆固醇生物合成具有抑制作用的吡咯衍生物的方法，更具体地涉及从1,4-二酮起始物质改进的合成方法，用于制备3,5-二羟基-7-吡咯-1-基庚酸。该发明还涉及该过程中的中间体。

  公开号：

  EP1705175A1
• 作为产物：
  描述：

  Boc-beta-丙氨酸 、 magnesium salt of tert-butyl hydrogen malonate 在 N,N'-羰基二咪唑 、 sodium hydrogen sulfate 作用下， 以 四氢呋喃 、 水 、 乙酸乙酯 为溶剂， 反应 2.0h， 以93%的产率得到tert-butyl 5-tert-butoxycarbonylamino-3-oxopentanoate
  参考文献：
  名称：

  Process for preparing C5 products and their use for Atorvastatin synthesis

  摘要：

  本发明涉及一种制备C5中间体并将其用于制备一类对人类胆固醇生物合成具有抑制作用的吡咯衍生物的方法，更具体地涉及从1,4-二酮起始物质改进的合成方法，用于制备3,5-二羟基-7-吡咯-1-基庚酸。该发明还涉及该过程中的中间体。

  公开号：

  EP1705175A1

文献信息

• Process for preparing C5 products and their use for Atorvastatin synthesis
  申请人：Ratiopharm GmbH

  公开号：EP1705175A1

  公开（公告）日：2006-09-27

  The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process

  本发明涉及一种制备C5中间体并将其用于制备一类对人类胆固醇生物合成具有抑制作用的吡咯衍生物的方法，更具体地涉及从1,4-二酮起始物质改进的合成方法，用于制备3,5-二羟基-7-吡咯-1-基庚酸。该发明还涉及该过程中的中间体。
• Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide
  作者：Nobutoshi Murakami、Satoru Tamura、Weiqi Wang、Tatsuya Takagi、Motomasa Kobayashi

  DOI：10.1016/s0040-4020(01)00339-8

  日期：2001.5

  In order to produce stable analogs in blood of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized four analogs in which the 15-20 ester linkage was modified. Among them, the carba analog and 20-deoxo analog showed stability in serum. The conformation of arenastatin A and its three analogs were analyzed by distance-restrained molecular dynamic calculation to elucidate a three-dimensional stereostructure contributing to the extremely potent cytotoxicity of arenastatin A. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Synthesis and biological property of carba and 20-Deoxo analogues of arenastatin A
  作者：Nobutoshi Murakami、Weiqi Wang、Satoru Tamura、Motomasa Kobayashi

  DOI：10.1016/s0960-894x(00)00356-5

  日期：2000.8

  The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.
• WO2007/131528
  申请人：——

  公开号：——

  公开（公告）日：——