32-hydroxydotriacontanoic acid | 52900-19-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 32-hydroxydotriacontanoic acid
• 英文别名: 32-hydroxy-dotriacontanoic acid；32-Hydroxy-dotriacontansaeure；32-hydroxy dotriacontanoic acid；32-Hydroxy-docotriacontansaeure；omega-Hydroxydotriacontanoic acid
• CAS: 52900-19-3
• 化学式: C₃₂H₆₄O₃
• 分子量: 496.858
• InChiKey: CTCQDFGRDYVMML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.9
• 重原子数：
  35
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  16-溴十六烷酸	16-bromohexadecanoic acid	2536-35-8	C16H31BrO2	335.325
  ——	methyl 32-hydroxydotriacontanoate	——	C33H66O3	510.885

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	oxacyclotritriacontan-2-one	81155-75-1	C32H62O2	478.843

反应信息

• 作为反应物：
  描述：

  32-hydroxydotriacontanoic acid 生成 oxacyclotritriacontan-2-one
  参考文献：
  名称：

  Horn; Pretorius, Chemistry and industry, 1956, p. R 27

  摘要：

  DOI：
• 作为产物：
  描述：

  16-溴-1-十六烷醇 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 草酰氯 、 palladium 10% on activated carbon 、 氢气 、 sodium hexamethyldisilazane 、 4-甲基苯磺酸吡啶 、 二甲基亚砜 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 87.5h， 生成 32-hydroxydotriacontanoic acid
  参考文献：
  名称：

  Scalable Synthesis of Human Ultralong Chain Ceramides

  摘要：

  Ceramides with ultralong chains (>30 carbons), also known as acylceramides, play a critical role in the survival of mammals on dry land. An efficient and scalable synthesis of four major classes of ultralong human skin ceramides is reported. The key approach involves the use of a succinimidyl ester that acts as a protective group, helps overcome the extremely low solubility, and simultaneously activates the fatty acid for its clean and high-yielding attachment to a sphingoid base.

  DOI：

  10.1021/acs.orglett.5b02816

文献信息

• Process for preparing hydroxycarboxylic acids
  申请人：UNILEVER PLC

  公开号：EP0711746A1

  公开（公告）日：1996-05-15

  A new synthesis of ω-hydroxy acids, which employs commercially available starting materials and lowers the cost of production. The process involves coupling a fatty acyl group by enamine chemistry, followed by a ring expansion and selective reduction of ketoacid.

  一种新的ω-羟基酸合成法，它采用了市场上可买到的起始原料，并降低了生产成本。该工艺包括用烯胺化学方法偶联脂肪酰基，然后进行扩环和选择性还原酮酸。
• Cosmetic compositions containing lactate dehydrogenase inhibitors
  申请人：UNILEVER PLC

  公开号：EP0722715B1

  公开（公告）日：2001-10-24
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
• CONDENSATION POLYMERS WITH MODIFIED PROPERTIES
  申请人：Graichen Florian Hans Maximilian

  公开号：US20110136988A1

  公开（公告）日：2011-06-09

  The present invention relates to a method of preparing a polymer composition, the method comprising melt mixing an aliphatic condensation polymer with a cyclic ester of general formula (I) where X is an optionally substituted aliphatic hydrocarbon having 2 or more carbon atoms present in the cycle.
• US5502226A
  申请人：——

  公开号：US5502226A

  公开（公告）日：1996-03-26