D-Ala-Gly-OBzl*HCl | 64410-45-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-Ala-Gly-OBzl*HCl
• 英文别名: H-(D)Ala-Gly-OBzl.hydrochloride；benzyl 2-[[(2R)-2-aminopropanoyl]amino]acetate;hydrochloride
• CAS: 64410-45-3
• 化学式: C₁₂H₁₆N₂O₃*ClH
• 分子量: 272.732
• InChiKey: OEHNLEPORPSQBG-SBSPUUFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.61
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  D-Ala-Gly-OBzl*HCl 在 palladium on activated charcoal 氢气 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、275.79 kPa 条件下， 反应 124.0h， 生成 Boc-酪氨酸-D-丙氨酸-甘氨酸
  参考文献：
  名称：

  Novel analogs of enkephalin: identification of functional groups required for biological activity

  摘要：

  Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substitutents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have significant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.

  DOI：

  10.1021/jm00184a010
• 作为产物：
  描述：

  Boc-D-Ala-Gly-OBzl 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以100%的产率得到D-Ala-Gly-OBzl*HCl
  参考文献：
  名称：

  Novel analogs of enkephalin: identification of functional groups required for biological activity

  摘要：

  Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substitutents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have significant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.

  DOI：

  10.1021/jm00184a010

文献信息

• Methods of preparing manganese complexes of nitrogen-containing
  申请人：Monsanto Company

  公开号：US05610293A1

  公开（公告）日：1997-03-11

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其表示为以下式子：##STR1## 其中R，R'，R1，R'1，R2，R'2，R3，R'3，R4，R'4，R5，R'5，R6，R'6，R7，R'7，R8，R'8，R9和R'9以及X，Y，Z和n如本文所定义，可用作治疗炎症性疾病状态和障碍，缺血/再灌注损伤，中风，动脉硬化，高血压以及所有其他氧化剂引起的组织损伤或损伤的治疗剂。
• Organic compounds
  申请人：Sandoz Ltd.

  公开号：US04438103A1

  公开（公告）日：1984-03-20

  The invention provides polypeptides of formula I, A--B--Gly--D--E I wherein A is Tyr or substituted Tyr, B is --Gly-- or --(D)Ala--, D is, for example, Phe or MePhe and E is, for example, --Met--X, --Leu--X,--Nle--X, --Nva--X, --Ile--X, methioninesulphoxide--X, methioninesulphone--X wherein X is --NR'R" or --OR'" and each of R', R" and R'" independently signifies hydrogen or alkyl of 1 to 5 carbon atoms, which compounds possess pharmacological activity, for example, analgesic activity.

  本发明提供了公式I的多肽，A-B-Gly-D-E I其中A为酪氨酸或取代的酪氨酸，B为-Gly-或-(D)Ala-，D为例如苯丙氨酸或MePhe，而E为例如-Met-X，-Leu-X，-Nle-X，-Nva-X，-Ile-X，甲硫氧基亮氨酸-X，甲硫酰基亮氨酸-X，其中X为-NR'R"或-OR'"，而R'、R"和R'"各自独立地表示1至5个碳原子的氢或烷基，这些化合物具有药理活性，例如镇痛活性。
• Manganese complexes of nitrogen-containing macrocyclic ligands effective
  申请人：G. D. Searle & Co.

  公开号：US06084093A1

  公开（公告）日：2000-07-04

  The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, and R'.sub.9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

  本发明涉及超氧化物歧化酶（SOD）的低分子量模拟物，其化学式为：##STR1## 其中R，R'，R1，R'1，R2，R'2，R3，R'3，R4，R'4，R5，R'5，R6，R'6，R7，R'7，R8，R'8，R9和R'9以及X，Y，Z和n的定义如本文所述，用作治疗炎症性疾病状态和疾病，缺血/再灌注损伤，中风，动脉粥样硬化，高血压以及所有氧化剂引起的组织损伤或损伤的情况下的治疗剂。