4,9,14,19,24,26,28,30,32,34-Decakis(3-bromopropoxy)hexacyclo[21.2.2.23,6.28,11.213,16.218,21]pentatriaconta-1(25),3(35),4,6(34),8(33),9,11(32),13(31),14,16(30),18,20,23,26,28-pentadecaene | 1370587-04-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4,9,14,19,24,26,28,30,32,34-Decakis(3-bromopropoxy)hexacyclo[21.2.2.23,6.28,11.213,16.218,21]pentatriaconta-1(25),3(35),4,6(34),8(33),9,11(32),13(31),14,16(30),18,20,23,26,28-pentadecaene
• CAS: 1370587-04-4
• 化学式: C₆₅H₈₀Br₁₀O₁₀
• 分子量: 1820.38
• InChiKey: YBHWNTIHDNKWMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  20.5
• 重原子数：
  85
• 可旋转键数：
  40
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  92.3
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  4,9,14,19,24,26,28,30,32,34-Decakis(3-bromopropoxy)hexacyclo[21.2.2.23,6.28,11.213,16.218,21]pentatriaconta-1(25),3(35),4,6(34),8(33),9,11(32),13(31),14,16(30),18,20,23,26,28-pentadecaene 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以98%的产率得到
  参考文献：
  名称：

  Ditopic CMPO-pillar[5]arenes as unique receptors for efficient separation of americium(iii) and europium(iii)

  摘要：

  涉及一种新类同源双亲CMPO-pillar[5]芳烃和镧系元素的独特宿主-客体识别过程被揭示为逐步进行，并与在酸性条件下高效和选择性地分离铀(iii)和镓(iii)有关。

  DOI：

  10.1039/c4cc09248a
• 作为产物：
  描述：

  对苯二酚 在 三氟化硼乙醚 、 potassium carbonate 作用下， 以 1,2-二氯乙烷 、 丙酮 为溶剂， 反应 24.0h， 生成 4,9,14,19,24,26,28,30,32,34-Decakis(3-bromopropoxy)hexacyclo[21.2.2.23,6.28,11.213,16.218,21]pentatriaconta-1(25),3(35),4,6(34),8(33),9,11(32),13(31),14,16(30),18,20,23,26,28-pentadecaene
  参考文献：
  名称：

  Phosphonium pillar[5]arenes as a new class of efficient biofilm inhibitors: importance of charge cooperativity and the pillar platform

  摘要：

  使用pillar [5]芳烃共轭物抑制生物膜形成（MBIC₅₀=0.67-1.66μM）。

  DOI：

  10.1039/c6cc05170g

文献信息

• Non‐Covalent Interactions Enable the Length‐Controlled Generation of Discrete Tubes Capable of Guest Exchange
  作者：Shixin Fa、Yoko Sakata、Shigehisa Akine、Tomoki Ogoshi

  DOI：10.1002/anie.201916515

  日期：2020.6.8

  preparation of length‐controlled discrete tubular structures by homo‐/co‐assembly of rim‐differentiated and peralkylamino‐substituted pillar[5]arenes via hydrogen bonds and salt bridges. By dimerization and trimerization, the expanded tubes show a fivefold helical structure and stepwise binding, respectively. We found that the exchange speed of guest molecules in the tubes could be controlled by varying

  由大环分子构成的密闭空间中的超分子化学吸引了很多关注，因为它可以利用大环腔体的特定结合特性。在这里，我们报告通过边缘差异化和过烷基氨基取代的支柱[5]芳烃通过氢键和盐桥的均/共组装制备长度可控制的离散管状结构。通过二聚和三聚，膨胀的管分别显示五重螺旋结构和逐步结合。我们发现，通过改变管长可以控制管中客体分子的交换速度。
• Ionic liquid pillar[5]arene: its ionic conductivity and solvent-free complexation with a guest
  作者：Tomoki Ogoshi、Naosuke Ueshima、Tada-aki Yamagishi、Yoshiyuki Toyota、Noriyoshi Matsumi

  DOI：10.1039/c2cc30589e

  日期：——

  A room-temperature ionic liquid containing macrocyclic compound pillar[5]arene in its core was synthesized. The ionic liquid showed high thermal stability, moderate ionic conductivity and solvent-free complexation ability with the guest tetracyanoethylene.

  合成了一种以大环化合物支柱[5]炔为核心的室温离子液体。该离子液体具有较高的热稳定性、适度的离子导电性以及与客体四氰基乙烯的无溶剂络合能力。
• Host–guest synergistic enhancement of antibacterial effect by a supramolecular strategy
  作者：Mengke Ma、Junyi Chen、Yahan Zhang、Xinbei Du、Longming Chen、Xiang Yu、Zhengui Zhou、Yang Liu、Qingbin Meng

  DOI：10.1039/d2ob01848a

  日期：——

  A supramolecular synergistic antibacterial strategy involving direct complexation of a commercial antibacterial agent, azelaic acid (AzA) by a cationic pillar[5]arene (WP5A) is described.

  描述了一种超分子协同抗菌策略，涉及商业抗菌剂油酸（AzA）通过阳离子柱[5]芳烃（WP5A）的直接络合作用。
• Temperature-driven chirality inversion of complexes of bromoalkyl-substituted pillar[5]arenes
  作者：Chunhong Liu、Jiecheng Ji、Wanhua Wu、Cheng Yang

  DOI：10.1016/j.tetlet.2023.154644

  日期：2023.7

  A variety of bromoalkyl-substituted pillar[5]arenes (PBrn) were synthesized, and the complexation of PBrn with amino acid derivatives induced chiroptical response as a result of the Rp and Sp conformational equilibrium shift. The induced circular dichroism (CD) properties were a function of the chemical structure of amino acid derivatives. Interestingly, the CD induced by the cysteine derivative was

  合成了多种溴代烷基取代的柱[5]芳烃( P Brn )， P Brn与氨基酸衍生物的络合由于R p和S p构象平衡位移而诱导手性光学响应。诱导圆二色性（CD）特性是氨基酸衍生物化学结构的函数。有趣的是，半胱氨酸衍生物诱导的CD严重依赖于温度，温度的变化甚至导致CD符号的反转。P Brn独特的手性光学诱导行为与烷基取代的柱[5]芳烃不同，讨论了手性光学反转的可能机制。
• Molecular Recognition with Microporous Multilayer Films Prepared by Layer-by-Layer Assembly of Pillar[5]arenes
  作者：Tomoki Ogoshi、Shu Takashima、Tada-aki Yamagishi

  DOI：10.1021/jacs.5b07415

  日期：2015.9.2

  Pillar[5]arene-based multilayer films are constructed by layer-by-layer assembly with consecutive adsorption of cationic and anionic pillar[5]arenes. The films have active pores that allow shape-selective uptake of dinitrobenzene isomers: the film adsorbs para-dinitrobenzene, but not ortho- and meta-dinitrobenzene. The ability of the film to adsorb para-dinitrobenzene is result of the surface electrostatic potential: para-dinitrobenzene adsorbs on films with a positive surface, but not on films with a negative surface. The adsorbed amount of para-dinitrobenzene exponentially increases with increasing number of deposited layers.