3-(1-ethynyl-cyclopentyloxy)-propionitrile | 874488-20-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(1-ethynyl-cyclopentyloxy)-propionitrile
• 英文别名: 3-(1-Aethinyl-cyclopentyloxy)-propionitril
• CAS: 874488-20-7
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: JNFQXYHTOGFWNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  12.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  33.02
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-(1-ethynyl-cyclopentyloxy)-propionitrile 在 盐酸 、 甲醇 作用下， 生成 3-(1-ethynyl-cyclopentyloxy)-propionic acid methyl ester
  参考文献：
  名称：

  Nasarow; Schwechgeimer, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1956, p. 827,831; engl. Ausg. S. 845, 849

  摘要：

  DOI：
• 作为产物：
  描述：

  1-乙炔基环戊醇 、 丙烯腈 在 氢氧化钾 作用下， 生成 3-(1-ethynyl-cyclopentyloxy)-propionitrile
  参考文献：
  名称：

  Intrinsic Inhibition of Aldose Reductase

  摘要：

  The development of aldose reductase inhibitors for the treatment of diabetic complications, such as cataract and retinopathy, has been of intense interest in the pharmaceutical community for the last 20 years. To date, aldose reductase inhibitors have been synthetically developed from leads obtained from in vitro screening studies. Recently, we have observed that mammalian tissues contain intrinsic inhibitors of aldose reductase, which may be used as potential drugs for treating diabetic complications with potentially less side effects than synthetic aldose reductase inhibitors. Intrinsic inhibitor(s) of aldose reductase have been observed in the methanolic extracts from rat and human kidneys and bovine lenses that were subjected to a number of chromatographic techniques, including counter current chromatography, flash chromatography, gel filtration and high pressure liquid chromatography. This inhibition results from a direct interaction between the inhibitor and enzyme. The intrinsic inhibitor, present in the lipophilic fraction of human kidney and bovine lens extracts, can easily penetrate into the lens to inhibit sugar alcohol formation. Intraperitoneal injection of partially purified bovine lens extract inhibited lens polyol formation in young rats fed 50% galactose diet.

  DOI：

  10.1089/108076801753162780

文献信息

• Nasarow; Schwechgeimer, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 514; engl. Ausg.S.498
  作者：Nasarow、Schwechgeimer

  DOI：——

  日期：——