6-(2-hydroxyhexafluoro-2-propyl)-2,2,4-trimethyl-1,2-dihydroquinoline 1-oxide | 122976-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(2-hydroxyhexafluoro-2-propyl)-2,2,4-trimethyl-1,2-dihydroquinoline 1-oxide
• CAS: 122976-61-8
• 化学式: C₁₅H₁₄F₆NO₂
• 分子量: 354.272
• InChiKey: DPTFLDDCRRIGHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-(2-hydroxyhexafluoro-2-propyl)-2,2,4-trimethyl-1,2-dihydroquinoline 1-oxide 在 C(CH₃)(CH₃)CH(CH₃)N(CH₃)C(CH₃)(C₆H₁₃)N-OH 作用下， 以 正己烷 为溶剂， 生成 2,2,4-Trimethyl-6-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-2H-quinolin-1-ol
  参考文献：
  名称：

  位阻羟胺-硝酰基体系中氢原子的交换反应

  摘要：

  测定了喹啉、咪唑啉、吡咯烷和哌啶系列的空间位阻硝酰基自由基-羟胺以及二芳基羟胺体系中氢原子的直接和反向交换反应的速率常数。建立了水胺还原能力的量表。低同位素效应值是羟胺-硝酰基自由基体系中氢交换反应的典型特征。

  DOI：

  10.1007/bf02495549
• 作为产物：
  描述：

  6-(2-hydroxyhexafluoro-2-propyl)-2,2,4-trimethyl-1,2-dihydroquinoline 在 sodium tungstate 、 双氧水 作用下， 以 甲醇 为溶剂， 反应 50.0h， 以38%的产率得到6-(2-hydroxyhexafluoro-2-propyl)-2,2,4-trimethyl-1,2-dihydroquinoline 1-oxide
  参考文献：
  名称：

  Reactions of 2,2,4-trimethyl-1,2-dihydroquinoline and its derivatives with hexafluoroacetone and methyl trifluoropyruvate

  摘要：

  DOI：

  10.1007/bf00953643

文献信息

• Effect of the chemical structure of nitroxyl radicals on their reactivity in the reaction with hydrazobenzene and tetranitromethane
  作者：A. D. Malievskii、S. V. Koroteev、L. B. Volodarskii、A. B. Shapiro

  DOI：10.1007/bf00958847

  日期：1990.11

  The reaction rate constants of reduction of stable radicals of different classes by hydrazobenzene in hexane at approximately 20-degrees-C, in the range of 0.4-5.10(3) M-1.sec-1, were determined; a single scale of the oxidative properties of stable nitroxyl radicals was constructed. The rate constants of oxidation of a series of nitroxyl radicals by tetranitromethane in aqueous medium at approximately 20-degrees-C, in the range of 0.06-10 M-1.sec-1, were determined. It was shown that the oxidative properties of the nitroxyl group decrease slightly with an increase in its reducing properties for nitroxyl radicals of the piperidine and imidazoline series in reactions with ascorbic acid and tetranitromethane in aqueous medium, respectively.