6,6-dimethoxyhexanoic acid | 153706-85-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6,6-dimethoxyhexanoic acid
• CAS: 153706-85-5
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: DYGKLHQONXPPKW-UHFFFAOYSA-N

物化性质

• 沸点：
  265.2±30.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,6-dimethoxyhexanoic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成
  参考文献：
  名称：

  Synthesis of Glycoconjugate Vaccines against Shigella dysenteriae Type 1

  摘要：

  Syntheses of a hexadecasaccharide and smaller fragments corresponding to one-four repeating units of the O-specific polysaccharide of Shigella dysenteriae type 1 are reported in a reactive aglyconlinked from. Two tetrasaccharide donor/acceptor repeating units were assembled from monosaccharide precursors in a stepwise fashion and used in a linear, iterative manner to construct the higher-membered saccharides using Schmidt's glycosylation technique that proved superior to others tested. Single-point attachment of the saccharides to human serum albumin, using a secondary heterobifunctional spacer, afforded a range of glycoconjugates for a detailed evaluation of their immunological characteristics.

  DOI：

  10.1021/jo980660a
• 作为产物：
  描述：

  6-羟基己酸甲酯 在 lithium hydroxide 、 草酰氯 、 对甲苯磺酸 、 二甲基亚砜 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.25h， 生成 6,6-dimethoxyhexanoic acid
  参考文献：
  名称：

  Synthesis of Glycoconjugate Vaccines against Shigella dysenteriae Type 1

  摘要：

  Syntheses of a hexadecasaccharide and smaller fragments corresponding to one-four repeating units of the O-specific polysaccharide of Shigella dysenteriae type 1 are reported in a reactive aglyconlinked from. Two tetrasaccharide donor/acceptor repeating units were assembled from monosaccharide precursors in a stepwise fashion and used in a linear, iterative manner to construct the higher-membered saccharides using Schmidt's glycosylation technique that proved superior to others tested. Single-point attachment of the saccharides to human serum albumin, using a secondary heterobifunctional spacer, afforded a range of glycoconjugates for a detailed evaluation of their immunological characteristics.

  DOI：

  10.1021/jo980660a

文献信息

• A Convenient Method for the Preparation of Acetal Carboxylic Acids by Nickel(II) Complex Catalyzed Oxygenation of α-Alkoxy Cyclic Ketones with Molecular Oxygen
  作者：Eiichiro Hata、Toshihiro Takai、Tohru Yamada、Teruaki Mukaiyama

  DOI：10.1246/cl.1994.535

  日期：1994.3

  In the presence of a catalytic amount of nickel(II) complex, various α-alkoxy cyclic ketones are smoothly oxygenated into acetal lactones by combined use of molecular oxygen and aldehydes at room temperature under an atmospheric pressure. Successive treatment of formed acetal lactones with hydrogen chloride in alcohols affords the corresponding acetal carboxylic acids in good to quantitative yields

  在催化量的镍(II)配合物存在下，各种α-烷氧基环酮在常温常压下，通过分子氧和醛的联合使用，顺利氧化成缩醛内酯。用醇中的氯化氢连续处理形成的缩醛内酯，以良好到定量的产率提供相应的缩醛羧酸。
• Nitrilases
  申请人：Verenium Corporation

  公开号：EP2327767A1

  公开（公告）日：2011-06-01

  The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and methods of use therefore are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

  本发明涉及硝化酶和编码硝化酶的核酸。此外，本发明还提供了设计新亚硝酸酯酶的方法和使用方法。在pH值和温度升高的情况下，这种氮基酶的活性和稳定性都有所提高。
• Cleaning method of containers and apparatus thereof
  申请人：Clariant International, Ltd.

  公开号：US20020026953A1

  公开（公告）日：2002-03-07

  A container cleaning apparatus comprises a solvent cleaning unit having a solvent cleaning chamber, and a rinsing unit having a rinsing chamber connected to the solvent cleaning chamber. Containers are conveyed by a conveyor through the solvent cleaning chamber and the rinsing chamber. The containers are cleaned by jetting a water-soluble or partially water-soluble solvent against the containers in the solvent cleaning chamber. Shutter devices have shutters disposed at an entrance to the solvent cleaning chamber and an exit from the solvent cleaning chamber, respectively, and capable of being moved between closed positions to close the entrance to and the exit from the solvent cleaning chamber and to isolate the solvent cleaning chamber from the rinsing chamber, and open positions to permit the containers to move from the solvent cleaning chamber to the rinsing chamber. During a solvent cleaning process for cleaning the containers with the solvent in the solvent cleaning chamber, the solvent cleaning chamber is isolated from the external space so that the solvent may not leak outside.

  一种容器清洗装置包括一个溶剂清洗单元（具有一个溶剂清洗室）和一个漂洗单元（具有一个与溶剂清洗室相连的漂洗室）。容器由传送带通过溶剂清洗室和漂洗室。在溶剂清洗室中，通过向容器喷射水溶性或部分水溶性溶剂来清洗容器。百叶窗装置的百叶窗分别设置在溶剂清洗室的入口和出口处，可以在关闭位置和打开位置之间移动，前者关闭溶剂清洗室的入口和出口，将溶剂清洗室与漂洗室隔离，后者允许容器从溶剂清洗室移动到漂洗室。在用溶剂清洗室中的溶剂清洗容器的溶剂清洗过程中，溶剂清洗室与外部空间隔离，使溶剂不会泄漏到外面。
• Syntheses of bifunctional compounds from cycloalkenes via ozonide intermediates
  作者：Yung-Son Hon、Jiann-Long Yan

  DOI：10.1016/s0040-4020(97)00207-x

  日期：1997.4

  The ozonolytic cleavage of cycloalkene in the presence of methyl pyruvate affords a tri-substituted ozonide. The resulted tri-substituted ozonide moiety contained three reactive centers (i.e. peroxide, ozonide ring proton and methoxycarbonyl group) which could be transformed to different functional groups under different conditions in good yields. It is a very efficient and versatile methodology to prepare the terminal differentiated compounds from symmetric cycloalkenes in two steps in high yields. (C) 1997 Elsevier Science Ltd.
• The ozonolytic cleavage of cycloalkenes in the presence of methyl pyruvate to yield the terminally differentiated compounds
  作者：Hon Yung-Son、Yanb Sann-Long

  DOI：10.1016/0040-4039(93)88113-w

  日期：1993.10