2-chloro-6-methoxy-8-nitro-quinoline | 52824-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-chloro-6-methoxy-8-nitro-quinoline
• 英文别名: 2-Chlor-6-methoxy-8-nitro-chinolin；2-chloro-6-methoxy-8-nitroquinoline；2-Chlor-6-methoxy-8-nitrochinolin
• CAS: 52824-29-0
• 化学式: C₁₀H₇ClN₂O₃
• 分子量: 238.63
• InChiKey: XKYYWFGJCJNRGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-chloro-6-methoxy-8-nitro-quinoline 在 盐酸 、 sodium hydroxide 作用下， 生成 2,6-dimethoxy-8-nitro-quinoline
  参考文献：
  名称：

  潜在抗疟药的合成；一些2-取代的8-（3-二乙基氨基丙基氨基）-喹啉。

  摘要：

  DOI：

  10.1021/ja01212a050
• 作为产物：
  描述：

  6-甲氧基-8-硝基喹啉 在 五氯化磷 、 双氧水 、 sodium hydroxide 作用下， 以 乙醇 、 三氯氧磷 为溶剂， 反应 15.0h， 生成 2-chloro-6-methoxy-8-nitro-quinoline
  参考文献：
  名称：

  N -METHYL-4-(QUINOLIN-2-YL)PYRIDIN-2-AMINE COMPOUNDS

  摘要：

  The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3are as defined in the specification. The compounds may be radiolabeled compounds and are useful for diagnostic imaging using positron emission tomography (PET). The compounds of the present disclosure may be used, for example, in diagnostic imaging of 4R tau aggregates.

  公开号：

  WO2024049976A1

文献信息

• Process for production of 8-NHR quinolines
  申请人：The United States of America as represented by the Secretary of the Army

  公开号：US04167638A1

  公开（公告）日：1979-09-11

  An improved process for producing 8-NHR quinolines from 8-aminoquinolines disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80.degree.-90.degree. C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol.

  一种改进的方法用于从8-氨基喹啉制备8-NHR喹啉。该方法包括在存在沸点为80度至90度的胺的情况下，将8-氨基喹啉与取代烷基卤化物反应。胺起到酸受体的作用，从而形成的胺盐可以在无需昂贵或耗时的纯化步骤的情况下有效地与形成的8-NHR喹啉分离。反应可以在存在溶剂（如醇类）的情况下进行。
• Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
  申请人：Sun Aiming

  公开号：US20110281908A1

  公开（公告）日：2011-11-17

  Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.

  本文提供了新型分子伴侣热休克蛋白90（Hsp90）抑制剂的类别和制备方法。这些化合物可用于治疗和预防癌症和其他与Hsp90相关的疾病，如炎症和神经退行性疾病。本文还提供了治疗和预防癌症和其他Hsp90相关疾病的方法。该方法包括向患者施用治疗有效量的Hsp90抑制剂。
• US4167638A
  申请人：——

  公开号：US4167638A

  公开（公告）日：1979-09-11
• US4431807A
  申请人：——

  公开号：US4431807A

  公开（公告）日：1984-02-14
• N -METHYL-4-(QUINOLIN-2-YL)PYRIDIN-2-AMINE COMPOUNDS
  申请人：[en]ABBVIE INC.

  公开号：WO2024049976A1

  公开（公告）日：2024-03-07

  The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3are as defined in the specification. The compounds may be radiolabeled compounds and are useful for diagnostic imaging using positron emission tomography (PET). The compounds of the present disclosure may be used, for example, in diagnostic imaging of 4R tau aggregates.