4-chloro-6-(4-fluorophenoxy)pyrimidine | 124041-01-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-chloro-6-(4-fluorophenoxy)pyrimidine
• 英文别名: 6-(4-fluorophenoxy)-4-chloropyrimidine
• CAS: 124041-01-6
• 化学式: C₁₀H₆ClFN₂O
• mdl: MFCD00508262
• 分子量: 224.622
• InChiKey: KNGGWBVOURCRQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-6-(4-fluorophenoxy)pyrimidine 生成 ethyl <6-(4-fluorophenoxy)-4-pyrimidinylthio>acetate
  参考文献：
  名称：

  VAJNILAVICHYUS, P. J.;SYADYARYAVICHYUTE, V. YU.;ABRAMOVA, G. L.;ANDREEVA,+, 14 MENDELEEV. SEZD PO OBSHCH. I PRIKL. XIMII, M.,(1989) S. 244

  摘要：

  DOI：
• 作为产物：
  描述：

  4,6-二氯嘧啶 生成 4-chloro-6-(4-fluorophenoxy)pyrimidine
  参考文献：
  名称：

  VAJNILAVICHYUS, P. J.;SYADYARYAVICHYUTE, V. YU.;ABRAMOVA, G. L.;ANDREEVA,+, 14 MENDELEEV. SEZD PO OBSHCH. I PRIKL. XIMII, M.,(1989) S. 244

  摘要：

  DOI：

文献信息

• Thiazolidinedione and pharmaceutical composition comprising the same
  申请人：——

  公开号：US20040122031A1

  公开（公告）日：2004-06-24

  The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof. Further, the present invention provides a pharmaceutical composition comprising the compound represented in formula (1) below, 1 wherein: X represents a carbon or nitrogen atom, Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group, Z represents an oxygen, nitrogen, or sulfur atom, and R 1 and R 2 each represent a hydrogen atom; or R 1 and R 2 together form a bond.

  本发明涉及一种噻唑烷二酮衍生物，其表示为下式（1），其药学上可接受的盐和/或药学上可接受的溶剂。此外，本发明提供了一种含有下式（1）所表示的化合物的制药组合物，其中：X表示碳或氮原子，Y表示氢原子，烷基，烷氧基，卤素或芳基，Z表示氧，氮或硫原子，R1和R2各自表示氢原子；或R1和R2结合形成键。
• Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione
  作者：H LEE、B KIM、J AHN、S KANG、J LEE、J SHIN、S AHN、S LEE、S YOON

  DOI：10.1016/j.ejmech.2005.03.019

  日期：2005.9

  We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKA(y) mice. From the results, novel compounds, 5c and 5g, exhibited considerably more potent biological activity than that of the reference compounds, pioglitazone and rosiglitazone, respectively. (c) 2005 Elsevier SAS. All rights reserved.
• Synthesis and biological activity of ethyl (6-phenoxy-4-pyrimidinylthio)acetates
  作者：P. I. Vainilavichyus、V. -S. M. Rochka、V. Yu. Syadyaryavichyute、A. A. Denene、A. B. Bezanskene、G. L. Abramova

  DOI：10.1007/bf01145809

  日期：1989.6
• Guan, Li-Ping; Yan, Zheng-Shun; Tong, Guo-Zhong, Medicinal Chemistry, 2012, vol. 8, # 6, p. 1076 - 1083,8
  作者：Guan, Li-Ping、Yan, Zheng-Shun、Tong, Guo-Zhong、Qu, You-Le、Sui, Xin、Chang, Yue

  DOI：——

  日期：——
• VAJNILAVICHYUS, P. I.;ROCHKA, V. -S. M.;SYADYARYAVICHYUTE, V. YU.;DENENE,+, XIM.-FARMATS. ZH., 23,(1989) N, S. 705-707
  作者：VAJNILAVICHYUS, P. I.、ROCHKA, V. -S. M.、SYADYARYAVICHYUTE, V. YU.、DENENE,+

  DOI：——

  日期：——