16-Hydroxy-cis-hexadec-9-enoic acid | 1619-68-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 16-Hydroxy-cis-hexadec-9-enoic acid
• 英文别名: 16-hydroxy-(Z)-9-hexadecenoic acid；16-hydroxyhexadec-cis-9-enoic acid；16-hydroxyhexadec-9(Z)-enoic acid；cis-16-Hydroxy-hexadec-9-enolsaeure；cis-16-Hydroxy-hexadecen-(9)-saeure；16-Hydroxy-(Z)-9-hexadecensaeure；16-hydroxy-9Z-hexadecenoic acid；(Z)-16-hydroxyhexadec-9-enoic acid
• CAS: 1619-68-7
• 化学式: C₁₆H₃₀O₃
• 分子量: 270.412
• InChiKey: RPQJFAIEPUKQHK-IWQZZHSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  16-Hydroxy-cis-hexadec-9-enoic acid 在 吡啶 、 硫酸 、 sodium iodide 作用下， 以 丙酮 为溶剂， 生成 Methyl 16-iodo-(Z)-9-hexadecenoate
  参考文献：
  名称：

  Subramanian, G. B. V.; Chander, Yougesh; Sood, Rakesh Chandra, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 5, p. 414 - 418

  摘要：

  DOI：
• 作为产物：
  描述：

  十四烷 生成 16-Hydroxy-cis-hexadec-9-enoic acid
  参考文献：
  名称：

  Tulloch,A.P.; Spencer,J.F.T., Canadian Journal of Chemistry, 1968, vol. 46, p. 1523 - 1528

  摘要：

  DOI：

文献信息

• [EN] IDEBENONE COMPOUNDS<br/>[FR] COMPOSÉS D'IDÉBÉNONE
  申请人：TRAVECTA THERAPEUTICS PTE LTD

  公开号：WO2021211436A1

  公开（公告）日：2021-10-21

  The present application provides idebenone derivatives or analogues useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating the disease or disorder are also provided.

  本申请提供了对治疗患有疾病或疾病的主体有用的异戊醌衍生物或类似物。还提供了包含这些化合物的药物组合物以及治疗该疾病或疾病的方法。
• Direct Macrolactonization of Seco Acids via Hafnium(IV) Catalysis
  作者：Mylène de Léséleuc、Shawn K. Collins

  DOI：10.1021/acscatal.5b00082

  日期：2015.3.6

  Efficient direct macrolactonization of seco acids can be catalyzed by Hf(OTf)4 in high yields, forming water as the sole byproduct. The Hf(OTf)4 catalyst possesses unique reactivity characteristics relative to other Lewis acids, as it promotes macrolactonization over hydrolysis even in the presence of excess water. In addition to forming a variety of macrolactones and benzolactones (55–90%), intermolecular

  Hf（OTf）4可以高产率催化山梨酸的高效直接大环内酯化，形成水作为唯一的副产物。Hf（OTf）4相对于其他路易斯酸，该催化剂具有独特的反应特性，因为即使在存在过量水的情况下，它也比水解作用促进大内酯化。除了形成各种大分子内酯和苯并内酯（55-90％）外，羧酸和醇的分子间直接酯化也是可能的，并证明了与常见的氨基甲酸酯，甲硅烷基醚，烷氧基甲基醚和乙缩醛保护基的相容性。开发的所有大环内酯化和酯化方法都是操作简单的“一锅法”反应，可利用市售催化剂，而无需缓慢添加或共沸技术。
• [EN] METHOD OF REDUCING SPOILAGE IN HARVESTED PRODUCE DURING STORAGE AND SHIPPING<br/>[FR] PROCÉDÉ DE RÉDUCTION DE LA DÉTÉRIORATION DE PRODUITS RÉCOLTÉS PENDANT LE STOCKAGE ET L'EXPÉDITION
  申请人：APEEL TECH INC

  公开号：WO2017172951A1

  公开（公告）日：2017-10-05

  Described herein are formulations and methods of reducing spoilage in harvested produce by reducing the rate of water or mass loss, thereby resulting in high quality produce with lower rates of spoilage. The present disclosure provides coatings and methods of coating produce to prevent moisture loss from produce during storage and shipment of the produce. This in turn allows the produce to be shipped and stored at lower relative humidity (e.g., lower than industry standards for shipment and storage, or lower than about 90% relative humidity), which can help delay the growth of biotic stressors such as fungi, bacteria, viruses, and/or pests.

  本文描述了一种减少收获农产品变质的配方和方法，通过减少水分或质量的流失速率，从而获得质量高、变质率低的农产品。本文提供了覆盖物和覆盖农产品的方法，以防止农产品在储存和运输过程中失去水分。这反过来允许农产品在较低的相对湿度下运输和储存（例如低于行业运输和储存标准或低于约90%的相对湿度），这可以延迟生物胁迫因素（如真菌、细菌、病毒和/或害虫）的生长。
• Chemistry of lac resin-VIII
  作者：A.N. Singh、V.V. Mhaskar、Sukh Dev

  DOI：10.1016/0040-4020(78)80058-1

  日期：1978.1

  Preparation of (E)- and (Z)-16-hydroxy-9-hexadecenoic acids and erythro-aleuritic acid starting from naturally occurring aleuritic acid, is described. 16-Hydroxy-(Z)-9-hexadecenoic acid and jalaric acid have been selectively condensed to furnish the naturally occurring jalaric xxxter-I. The possible importance of this compound in the elaboration of lac resin by the insect is pointed out.

  描述了从天然存在的阿魏酸开始制备（E）-和（Z）-16-羟基-9-十六碳烯酸和赤型-阿尿酸。16-羟基-（Z）-9-十六碳烯酸和and草酸已被选择性地缩合以提供天然存在的j草xxxter-I。指出了该化合物在昆虫加工紫胶树脂中的可能重要性。
• NON-FLUORINATED URETHANE BASED COATINGS
  申请人：THE CHEMOURS COMPANY FC LLC

  公开号：US20160090508A1

  公开（公告）日：2016-03-31

  The present invention is an aqueous composition comprising at least one hydrophobic compound having at least one linkage of Formula I: —NHC(O)—X—  (I) wherein X is the residue of a cyclic or acyclic sugar alcohol which is substituted with at least one —R 1 ; —C(O)R 1 ; —(CH 2 CH 2 O) n (CH(CH 3 )CH 2 O) m R 2 ; —(CH 2 CH 2 O) n (CH(CH 3 )CH 2 O) m C(O)R 1 ; or mixtures thereof; where the cyclic or acyclic sugar alcohol is selected from a saccharide, reduced sugar, aminosaccharide, aldonic acid, or aldonic acid lactone; wherein each n is independently 0 to 20; each m is independently 0 to 20; m+n is greater than 0; each R 1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond; each R 2 is independently —H, a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond, or mixtures thereof.

  本发明涉及一种水性组合物，其中至少包含一种具有至少一个式I连接的疏水化合物：—NHC（O）—X—（I），其中X是一个环状或非环状糖醇的残基，该糖醇被至少一个—R1；—C（O）R1；—（CH2CH2O）n（CH（CH3）CH2O）mR2；—（CH2CH2O）n（CH（CH3）CH2O）mC（O）R1；或其混合物所取代，所述环状或非环状糖醇从葡萄糖、还原糖、氨基葡萄糖、醛酸或醛酸内酯中选择；其中每个n独立地为0到20；每个m独立地为0到20；m+n大于0；每个R1独立地为具有5到29个碳原子的线性或支链烷基，可选地包含至少1个不饱和键；每个R2独立地为—H，具有6到30个碳原子的线性或支链烷基，可选地包含至少1个不饱和键，或其混合物。