(ethylenediamine)((methylsulfinyl)acetato)platinum(II) nitrate | 137268-96-3

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: (ethylenediamine)((methylsulfinyl)acetato)platinum(II) nitrate
• 英文别名: Ethane-1,2-diamine;2-methylsulfinylacetate;platinum(2+);nitrate
• CAS: 137268-96-3
• 化学式: C₅H₁₃N₂O₃PtS*NO₃
• 分子量: 438.321
• InChiKey: YVMALAFYCLYLCF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.22
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  191
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (ethylenediamine)((methylsulfinyl)acetato)platinum(II) nitrate 在 NaCl 作用下， 以 重水 为溶剂， 生成 乙二胺氯化铂(II)
  参考文献：
  名称：

  Pasini, Alessandro; D'Alfonso, Giuseppe; Manzotti, Carla, Inorganic Chemistry, 1994, vol. 33, # 18, p. 4140 - 4148

  摘要：

  DOI：
• 作为产物：
  描述：

  ethylenediamine platinum(II) nitrate 、 (Methylsulfinyl)acetic acid 在 KOH 作用下， 以 水 为溶剂， 以74%的产率得到(ethylenediamine)((methylsulfinyl)acetato)platinum(II) nitrate
  参考文献：
  名称：

  Pasini, Alessandro; D'Alfonso, Giuseppe; Manzotti, Carla, Inorganic Chemistry, 1994, vol. 33, # 18, p. 4140 - 4148

  摘要：

  DOI：

文献信息

• Pasini, Alessandro; D'Alfonso, Giuseppe; Manzotti, Carla, Inorganic Chemistry, 1994, vol. 33, # 18, p. 4140 - 4148
  作者：Pasini, Alessandro、D'Alfonso, Giuseppe、Manzotti, Carla、Moret, Massimo、Spinelli, Silvano、Valsecchi, Mariella

  DOI：——

  日期：——
• Cisplatin analogues with sulfur donor ligands. (Ethylenediamine)platinum(II) complexes with ligands possessing a sulfinyl or sulfanyl group linked to an anionic oxygen donor atom. Reactivity and cytotoxicity
  作者：Alessandro Pasini、Paola Perego、Massimo Balconi、Mauro Lupatini

  DOI：10.1039/dt9950000579

  日期：——

  Complexes of formula [Pt(en)L]NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques. The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms. The reactivities of these complexes towards nucleophiles [Nu = Cl- or guanosine 5'-monophosphate(2-), GMP] have been investigated by H-1 NMR spectroscopy; GMP is more reactive than Cl-. The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex [Pt(en)L(Nu)] (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield [Pt(en)(Nu)2]. The complex with L = 2-(methylsulfanyl)phenolate is unreactive. The stable monosubstituted products have been characterized. There is little correlation between the rates and the modes of reactivity of complexes [Pt(en)L]NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.