2-methoxy-N-(3-phenylprop-2-yn-1-yl)aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-methoxy-N-(3-phenylprop-2-yn-1-yl)aniline
• 英文别名: 2-methoxy-N-(3-phenylprop-2-ynyl)aniline
• 化学式: C₁₆H₁₅NO
• mdl: MFCD17961678
• 分子量: 237.301
• InChiKey: SOUQJIPSMVUTKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxy-N-(3-phenylprop-2-yn-1-yl)aniline 在 silver(I) nitrite 作用下， 以 四氢呋喃 为溶剂， 以87%的产率得到1-(2-methoxyphenyl)-3-phenyl-1H-pyrazole 2-oxide
  参考文献：
  名称：

  AgNO₂ as the NO Source for the Synthesis of Substituted Pyrazole N-Oxides from N-Propargylamines

  摘要：

  A straightforward method for synthesizing the pyrazole N-oxides from N-propargylamines and AgNO2, through oxidation/cyclization reaction had been developed. AgNO2, was used as the NO source for the first time to synthesize pyrazole N-oxides. Various substituted groups on N-propargylamines proceeded smoothly, and the desired products were obtained in good yields.

  DOI：

  10.1021/acs.orglett.6b03021
• 作为产物：
  描述：

  邻甲氧基苯胺 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 potassium carbonate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.08h， 生成 2-methoxy-N-(3-phenylprop-2-yn-1-yl)aniline
  参考文献：
  名称：

  AgNO₂ as the NO Source for the Synthesis of Substituted Pyrazole N-Oxides from N-Propargylamines

  摘要：

  A straightforward method for synthesizing the pyrazole N-oxides from N-propargylamines and AgNO2, through oxidation/cyclization reaction had been developed. AgNO2, was used as the NO source for the first time to synthesize pyrazole N-oxides. Various substituted groups on N-propargylamines proceeded smoothly, and the desired products were obtained in good yields.

  DOI：

  10.1021/acs.orglett.6b03021

文献信息

• Ag-Catalyzed or Ag/PPh₃-Catalyzed Chemoselective Switchable Cascade Reactions of <i>N</i>-Propargyl Thiocarbamoyl Fluorides and Malonate Esters
  作者：Zhongliang Cai、Junyi Zhou、Miao Yu、Liqin Jiang

  DOI：10.1021/acs.orglett.1c03950

  日期：2022.1.14

  The divergent chemoselective synthesis of 2-methylene-2,3-dihydrothiazoles and 4-benzylidene pyrrolidine-2-thiones (most with E stereoselectivity) from N-propargyl thiocarbamoyl fluorides and malonate esters in moderate to excellent yields with a broad substrate scope and functional group tolerance has been accomplished. AgNTf2 catalyst at 60 °C in dichloroethane provided 4-benzylidene pyrrolidine-2-thiones

  从N-炔丙基硫代氨基甲酰氟和丙二酸酯以中等至优异的产率，具有广泛的底物范围和功能性，不同的化学选择性合成 2-亚甲基-2,3-二氢噻唑和 4-亚苄基吡咯烷-2-硫酮（大多数具有 E 立体选择性）群体容忍度已经完成。AgNTf 2催化剂在 60 °C 下在二氯乙烷中提供 4-亚苄基吡咯烷-2-硫酮。AgOTf 催化剂和 PPh 3配体在回流乙腈中导致形成的 α,α-二酯硫代酰胺中间体的反应性发生完全转换，随后异构化得到 2-亚甲基-2,3-二氢噻唑。
• Electricity-driven, oxidative C–H selenylative and tellurylative annulation of N-(2-alkynyl)anilines: sustainable synthesis of 3-selanyl/tellanylquinolines
  作者：Ainala Naresh、H. Sai Keerthana、Nilanjana Mukherjee、Tanmay Chatterjee

  DOI：10.1039/d4cc01780c

  日期：——

  A metal- and oxidant-free, electricity-driven C–H selenylative and tellurylative annulation of N-(2-alkynyl)anilines with diorganyl dichalcogenides is developed to access 3-chalcogenylquinolines.