(R)-3-(benzyloxy)-2-phenylpropanoic acid | 510730-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-3-(benzyloxy)-2-phenylpropanoic acid
• 英文别名: (2R)-2-phenyl-3-phenylmethoxypropanoic acid
• CAS: 510730-56-0
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: UBAAZUSNCMSIKJ-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-3-(benzyloxy)-2-phenylpropanoic acid 在 ammonium hydroxide 、 三乙胺 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 5.5h， 生成 tert-butyl N-[(1R)-1-phenyl-2-phenylmethoxyethyl]carbamate
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4
• 作为产物：
  描述：

  (S)-4-benzyl-3-phenylacetyl-2-oxazolidinone 在 lithium hydroxide 、 双氧水 、 四氯化钛 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 (R)-3-(benzyloxy)-2-phenylpropanoic acid
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4

文献信息

• SONIC HEDGEHOG MODULATORS
  申请人：Buhrlage Sara

  公开号：US20140094462A1

  公开（公告）日：2014-04-03

  Sonic Hedgehog modulators and methods of use thereof are provided for.

  索尼克刺猬调节剂及其使用方法已提供。
• Diastereoselective Reduction and Organometal Addition to 1-Alkoxy-2-phenylalkan-3-ones
  作者：Giuseppe Guanti、Luca Banfi、Renata Riva

  DOI：10.1016/0040-4020(95)00602-5

  日期：1995.9

  The reduction with various hydrides and the addition of some Grignard reagents and alkyl lithiums to various protected 1-hydroxy-2-phenylalkan-3-ones furnished respectively the corresponding secondary and tertiary alcohols with a diastereoselectivity from good to excellent. Both processes were stereoconservative, no racemization being observed.

  用各种氢化物进行还原，并向各种受保护的1-羟基-2-苯基铝烷-3-酮中添加一些格氏试剂和烷基锂，分别提供了相应的仲和叔醇，其非对映选择性从优至优。这两个过程都是立体保守的，没有观察到外消旋作用。
• Substituted dihydropyrrolopyrazole compound
  申请人：UBE INDUSTRIES, LTD.

  公开号：US10131679B2

  公开（公告）日：2018-11-20

  Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein L1 is an optionally substituted C1-6 alkylene group or the like, L2 is a single bond or the like, L3 is a single bond or the like, R1, R2, and R3 are each independently an optionally substituted C1-4 alkyl group or the like, R4 is a hydrogen atom or the like, and R5 is a hydrogen atom or the like.

  本文提供了一种由式（I）代表的化合物或其药理学上可接受的盐： 其中 L1 是任选取代的 C1-6 亚烷基或类似物，L2 是单键或类似物，L3 是单键或类似物，R1、R2 和 R3 各自独立地是任选取代的 C1-4 烷基或类似物，R4 是氢原子或类似物，R5 是氢原子或类似物。
• SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND
  申请人：Ube Industries, Ltd.

  公开号：EP3214086B1

  公开（公告）日：2021-09-22
• Synthesis of chiral α-amino acids
  作者：Tushar K Chakraborty、Animesh Ghosh

  DOI：10.1016/s0040-4039(02)02433-4

  日期：2002.12

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.