2-benzhydryl-3-oxo-N,3-diphenylpropanamide | 128316-23-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-benzhydryl-3-oxo-N,3-diphenylpropanamide
• CAS: 128316-23-4
• 化学式: C₂₈H₂₃NO₂
• 分子量: 405.496
• InChiKey: RLRQETIBBQFDHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  肉桂酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 49.0h， 生成 2-benzhydryl-3-oxo-N,3-diphenylpropanamide
  参考文献：
  名称：

  UV Light-Mediated Difunctionalization of Alkenes through Aroyl Radical Addition/1,4-/1,2-Aryl Shift Cascade Reactions

  摘要：

  UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.

  DOI：

  10.1021/acs.orglett.5b00144

文献信息

• FeCl2-Catalyzed Selective CC Bond Formation by Oxidative Activation of a Benzylic CH Bond
  作者：Zhiping Li、Lin Cao、Chao-Jun Li

  DOI：10.1002/anie.200701782

  日期：2007.8.27
• Brigadnova, E. V.; Maslivets, A. M.; Andreichikov, Yu. S., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 2.1, p. 274 - 277
  作者：Brigadnova, E. V.、Maslivets, A. M.、Andreichikov, Yu. S.

  DOI：——

  日期：——
• BRIGADNOVA, E. V.;MASLIVETS, A. N.;ANDREJCHIKOV, YU. S., ZH. ORGAN. XIMII, 26,(1990) N, S. 327-330
  作者：BRIGADNOVA, E. V.、MASLIVETS, A. N.、ANDREJCHIKOV, YU. S.

  DOI：——

  日期：——
• UV Light-Mediated Difunctionalization of Alkenes through Aroyl Radical Addition/1,4-/1,2-Aryl Shift Cascade Reactions
  作者：Lewei Zheng、Hongli Huang、Chao Yang、Wujiong Xia

  DOI：10.1021/acs.orglett.5b00144

  日期：2015.2.20

  UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.