N-(6-methyl-2-(cyclohexylthio)benzoyl)-8-aminoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(6-methyl-2-(cyclohexylthio)benzoyl)-8-aminoquinoline
• 英文别名: 2-cyclohexylsulfanyl-6-methyl-N-quinolin-8-ylbenzamide
• 化学式: C₂₃H₂₄N₂OS
• 分子量: 376.522
• InChiKey: SAZRNEXHZJNARD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环己硫醇 、 N-(2-methylbenzoyl)-8-aminoquinoline 在 4,7-二苯基-1,10-菲罗啉 、 copper(II) acetate monohydrate 、 silver carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 24.0h， 以93%的产率得到N-(6-methyl-2-(cyclohexylthio)benzoyl)-8-aminoquinoline
  参考文献：
  名称：

  Copper(II)-catalyzed direct thiolation of C–H bonds in aromatic amides with aryl and aliphatic thiols

  摘要：

  An efficient approach for Cu-catalyzed thiolation of C-sp2-H bonds of directing-group-containing aromatic amides with 1 degrees, 2 degrees, and 3 degrees aliphatic thiols and thiophenols has been developed. This method shows excellent functional group tolerance and provides a straightforward way for the preparation of aryl thioethers. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.042

文献信息

• Copper(II)-catalyzed direct thiolation of C–H bonds in aromatic amides with aryl and aliphatic thiols
  作者：Xiao-Biao Yan、Pin Gao、Hong-Bin Yang、Ying-Xiu Li、Xue-Yuan Liu、Yong-Min Liang

  DOI：10.1016/j.tet.2014.09.042

  日期：2014.11

  An efficient approach for Cu-catalyzed thiolation of C-sp2-H bonds of directing-group-containing aromatic amides with 1 degrees, 2 degrees, and 3 degrees aliphatic thiols and thiophenols has been developed. This method shows excellent functional group tolerance and provides a straightforward way for the preparation of aryl thioethers. (C) 2014 Elsevier Ltd. All rights reserved.