1-甲基喹啉氯化物 | 2525-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-甲基喹啉氯化物
• 英文名称: N-methylquinoline hydrochloride
• 英文别名: 1-methylquinolinium chloride；N-Methylquinolinium chloride；N-methylquinolinum chloride；1-methyl-quinolinium, chloride；Chinolin-Methochlorid；1-methylquinolin-1-ium;chloride
• CAS: 2525-21-5
• 化学式: C₁₀H₁₀N*Cl
• 分子量: 179.649
• InChiKey: FDZXBERTWXBXIP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.33
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-甲基喹啉氯化物 在 氢氧化钾 、 potassium permanganate 作用下， 以 氨 、 水 为溶剂， 生成 1-甲基-2-喹啉酮
  参考文献：
  名称：

  吡啶鎓和喹啉鎓盐的胺化

  摘要：

  描述了一种新的N-烷基吡啶鎓和喹啉鎓盐的胺化方法。它涉及用高锰酸钾对适当的底物在液氨中的溶液进行低温氧化。

  DOI：

  10.1016/0040-4039(84)80125-2
• 作为产物：
  描述：

  N-methylquinolinium iodide 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 1-甲基喹啉氯化物
  参考文献：
  名称：

  Synthesis and reactivities of 1-methyl-2-trichloromethyl-1,2-dihydroquinolines.

  摘要：

  季喹啉盐（1-甲基、1,3-二甲基和 1,4-二甲基碘化喹啉）与氯仿和氢氧化钠在甲醇中生成的三氯甲基碳离子反应，生成 1,2-二氢加合物 1-甲基-2-三氯甲基-1,2-二氢喹啉。在类似的反应条件下，1, 2-二甲基喹啉盐会生成另一种加成产物，并与二氯甲烷发生进一步反应，生成二氯环丙烷融合化合物。根据所用催化剂的不同，还原 1，2-二氢加合物可得到 1-甲基-2-三氯甲基-1，2，3，4-四氢喹啉或 1-甲基-2-二氯甲基十氢喹啉。这些加合物是合成含氯杂环的有用中间体。

  DOI：

  10.1248/cpb.38.2577

文献信息

• Process for preparing organic sulfur acids or salts thereof
  申请人：——

  公开号：US20020161255A1

  公开（公告）日：2002-10-31

  A process for producing organic sulfur acid or a salt thereof of the present invention allows an organic substrate to react with a sulfur oxide in the presence of a metallic compound catalyst and in the absence of N-hydroxy and N-oxo cyclic imide compounds and thereby yields a corresponding organic sulfur acid or a salt thereof. Such organic substrates include, for example, (a) homocyclic or heterocyclic compounds having a methylene group, (b) compounds having a methine carbon atom, (c) compounds having a methyl group or methylene group at the adjacent position to an unsaturated bond, (d) non-aromatic heterocyclic compounds having a carbon-hydrogen bond at the adjacent position to a hetero atom, and (e) straight-chain alkanes. The sulfur oxide includes, for example, sulfur dioxide. This production process can efficiently produce an organic sulfur acid or a salt thereof under mild conditions.

  本发明的有机硫酸或其盐的生产方法允许有机底物在金属化合物催化剂存在下与硫氧化物反应，而无需N-羟基和N-氧代环亚酰胺化合物，并因此产生相应的有机硫酸或其盐。这样的有机底物包括，例如，(a) 具有亚甲基基团的同环或异环化合物，(b) 具有亚甲基碳原子的化合物，(c) 在不饱和键相邻位置具有甲基基团或亚甲基基团的化合物，(d) 具有相邻位置至杂原子处的碳氢键的非芳香杂环化合物，以及(e) 直链烷烃。硫氧化物包括，例如，二氧化硫。这种生产方法可以在温和条件下高效地生产有机硫酸或其盐。
• Catalyst comprising a cyclic imide compound and process for producing organic compounds using the catalyst
  申请人：——

  公开号：US20020128149A1

  公开（公告）日：2002-09-12

  A catalyst includes a cyclic imide compound having an N-substituted cyclic imide skeleton represented by following Formula (I): 1 wherein X is an oxygen atom or a hydroxyl group, and having a solubility parameter of less than or equal to 26 [(MPa) ½ ] as determined by Fedors method. The catalyst may further comprise a metallic compound. By allowing (A) a compound capable of forming a radical to react with (B) a radical scavenging compound in the presence of the catalyst, an addition or substitution reaction product between the compound (A) and the compound (B) or a derivative thereof can be obtained.

  催化剂包括具有由下式（I）表示的N-取代的环状亚酰亚胺骨架的环状亚酰亚胺化合物，其中X是氧原子或羟基，并且具有由Fedors方法确定的溶解度参数小于或等于26 [（MPa）½]。该催化剂还可以包括金属化合物。通过允许（A）能够形成自由基的化合物与（B）自由基清除化合物在催化剂存在的情况下发生反应，可以获得化合物（A）和化合物（B）之间的加成或取代反应产物或其衍生物。
• Process for producing organic peroxides
  申请人：——

  公开号：US20040039215A1

  公开（公告）日：2004-02-26

  A process of the invention allows a cycloalkane to react with oxygen in the presence of a catalytic imide compound having an N-hydroxy (or N-oxo) cyclic imide skeleton and thereby yields a corresponding bis(1-hydroxycycloalkyl)peroxide. The catalytic imide compound includes, for example, a compound represented by following Formula (1): 1 wherein R 1 and R 2 are each, for example, a hydrogen atom, a halogen atom, an alkyl group, an aryl group or a cycloalkyl group, where R 1 and R 2 may be combined to form a double bond, an aromatic or non-aromatic ring; and X is an oxygen atom or a hydroxyl group. The cycloalkane includes, for example, a cycloalkane having from 5 to 15 members. The invention can easily produce bis(1-hydroxycycloalkyl)peroxide from an inexpensive material.

  该发明的一个过程允许环烷烃在催化亚胺化合物的存在下与氧气发生反应，从而产生相应的双(1-羟基环烷基)过氧化物。催化亚胺化合物包括例如由以下化学式(1)表示的化合物：其中R1和R2可以分别是氢原子、卤素原子、烷基、芳基或环烷基，其中R1和R2可以结合形成双键、芳香环或非芳香环；X是氧原子或羟基。环烷烃包括例如具有5至15个成员的环烷烃。该发明可以从廉价材料轻松生产双(1-羟基环烷基)过氧化物。
• IMMOBILIZED CYCLIC IMIDE CATALYST AND PROCESS FOR OXIDATION OF ORGANIC COMPOUNDS WITH THE SAME
  申请人：Ishii Yasutaka

  公开号：US20100317869A1

  公开（公告）日：2010-12-16

  To provide a solid catalyst containing a cyclic imide skeleton which is easily available and easily separable from reaction products and which is easily recovered and regenerated, and free from reaction inhibitory factors; and a process for oxidation of organic compounds with the solid catalyst. An immobilized cyclic imide catalyst having a structure represented by following Formula (1), wherein X is oxygen or an —OR group (wherein R is hydrogen atom or a hydroxyl-protecting group); n is 0 or 1; Z 1 is a five- or six-membered cyclic imide skeleton to which an aromatic or nonaromatic ring Z 2 may be adjacent; elliptically shaped moiety S is an inorganic support; A 1 is a group linking silicon atom with the cyclic imide skeleton Z 1 or with the ring Z 2 and is either a divalent hydrocarbon group or a group composed of a divalent hydrocarbon group and an amide bond (—NHCO—); and the cyclic imide skeleton Z 1 and the ring Z 2 may each be substituted.

  提供一种含有环状酰亚胺骨架的坚固催化剂，该催化剂易于获取、易于与反应产物分离、易于回收和再生，且不含反应抑制因子；以及一种使用该固体催化剂氧化有机化合物的方法。该固定化环状酰亚胺催化剂具有以下式（1）所表示的结构，其中X为氧或—OR基团（其中R为氢原子或羟基保护基团）；n为0或1；Z1为一个五元或六元环状酰亚胺骨架，可以与一个芳香或非芳香环Z2相邻；椭圆形的基团S是无机支撑体；A1是将硅原子与环状酰亚胺骨架Z1或环Z2连接的基团，可以是二价烃基团或由二价烃基团和酰胺键（—NHCO—）组成的基团；环状酰亚胺骨架Z1和环Z2可以各自被取代。
• Catalyst comprising n-substituted cylic imides and processes for preparing organic compounds with the catalyst
  申请人：——

  公开号：US20030013603A1

  公开（公告）日：2003-01-16

  A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): 1 wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

  该发明的催化剂包括具有以下式（I）所表示的N-取代环状亚酰胺骨架的亚酰胺化合物：其中R是羟基保护基。首选R是可水解的保护基。R可以是从酸中消除OH基团得到的基团。这些酸包括例如羧酸，磺酸，碳酸，氨基甲酸，硫酸，硝酸，磷酸和硼酸。催化剂可以包括亚酰胺化合物和金属化合物的组合。在催化剂的存在下，将能够形成自由基的化合物（A）与自由基清除化合物（B）反应，从而生成化合物（A）和化合物（B）或其衍生物的加成或取代反应产物。该催化剂可以在温和条件下通过加成或取代反应以高选择性高产率地产生有机化合物。