1-chloro-2-methyl-1,3-butadiene | 98451-15-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 1-chloro-2-methyl-1,3-butadiene
• 英文别名: 1-chloro-2-methyl-buta-1,3-diene；1-Chlor-2-methyl-buta-1,3-dien；Isoprenyl chloride；α-Chlor-isopren；1,3-Butadiene, 1-chloro-2-methyl-；(1E)-1-chloro-2-methylbuta-1,3-diene
• CAS: 98451-15-1
• 化学式: C₅H₇Cl
• 分子量: 102.564
• InChiKey: ITQIRXSIZVCCPM-SNAWJCMRSA-N

物化性质

• 沸点：
  107.0±0.0 °C(Predicted)
• 密度：
  0.924±0.06 g/cm3(Predicted)
• 保留指数：
  701

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-chloro-2-methyl-1,3-butadiene 在 叔丁基邻苯二酚 sodium hydroxide 、 氯 、 高效阻聚剂N-NO 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 1,1-二氯-2-甲基丁-1,3-二烯
  参考文献：
  名称：

  Kaplanyan, E. E.; Adamyan, A. P.; Arakelyan, K. A., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 669 - 672

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯-2-甲基-1-丁烯 在 氯 、 sodium carbonate 作用下， 生成 1-chloro-2-methyl-1,3-butadiene
  参考文献：
  名称：

  Tischtschenko, Zhurnal Obshchei Khimii, 1936, vol. 6, p. 1118,1122

  摘要：

  DOI：

文献信息

• PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
  申请人：Columbia University

  公开号：US20150080394A1

  公开（公告）日：2015-03-19

  The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

  本发明提供了一些磷酸二酯酶抑制剂化合物。本发明还提供了一种筛选结合并调节磷酸二酯酶蛋白的化合物的方法。本发明还提供了通过向受体施加磷酸二酯酶结合化合物来治疗与淀粉样蛋白β沉积物积累相关的疾病的方法。
• Process for tanning hides
  申请人：Guidi, Loris

  公开号：EP0128702A1

  公开（公告）日：1984-12-19

  A process for tanning hides for soles or insoles with ammonium titanyl sulphate. The hides, subjected to soaking, liming, fleshing and deliming, are first treated with ammonium sulphate. Successively, ammonium titanyl sulphate as well as citric acid or an alkali metal citrate are gradually added to the bath, while maintaining the bath temperature at a value not exceeding 37 ° C and the bath pH at from 1.7 to 2.5. After each addition, the hides are treated until they have absorbed at least 90% of the soluble Ti (IV). Sodium sulphite and hexamethylenetetramine are then gradually added; this addition is such as to bring the final pH of the bath to 3.8 - 4.5 and to exhaust the bath of soluble Ti (IV). NaHC03 is then added until a pH value of the bath from 4.9 to 5.0 is reached, such pH being maintained for at least 2 hours. At least one tanning treatment with a tannin, either prior to the treatment with ammonium titanyl sulphate (pretanning), or after the treatment with NaHC03 (additional tanning) is carried out, such tanning being carried out with a synthetic or vegetable tannin in the former case, and with a synthetic tannin and/or rubber-like polymer in the latter case.

  一种用硫酸钛酸铵鞣制鞋底或鞋垫用皮革的工艺。首先用硫酸铵处理经过浸泡、浸灰、去皮和划线的皮革。随后，硫酸钛酸铵和柠檬酸或碱金属柠檬酸盐被逐渐加入浴槽中，同时保持浴槽温度不超过 37 °C，浴槽 pH 值在 1.7 至 2.5 之间。每次添加后，都要对皮革进行处理，直到它们吸收了至少 90% 的可溶性 Ti (IV)。然后逐渐加入亚硫酸钠和六亚甲基四胺；加入的方式是使熔池的最终 pH 值达到 3.8 - 4.5，并使熔池中的可溶性 Ti (IV) 全部耗尽。然后加入 NaHC03，直到浴液的 pH 值达到 4.9 至 5.0，这样的 pH 值至少要保持 2 个小时。在用硫酸钛酸铵处理之前（预鞣）或在用 NaHC03 处理之后（附加鞣制），至少用单宁酸进行一次鞣制处理，前者用合成单宁酸或植物单宁酸进行鞣制，后者用合成单宁酸和/或橡胶类聚合物进行鞣制。
• Alkenylated toluenediamines for use in preparing polyurethane/urea systems
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0235825A2

  公开（公告）日：1987-09-09

  This invention relates to a class of alkenylated toluenediamines having at least one alkenyl group ortho to an amine group. More particularly the toluenediamines are represented by the formula: wherein R1, R2, R3, R4 and Rs are hydrogen. C1-3 aliphatic, phenyl, halogen or alkoxy radicals, or R2 and R4 or Rs are bridged via an alkylene radical -(CH2)y- wherein y=2 to 5, and x is one or two provided that in said formula at least one of R1, R2, R3, R4 or R5 is C1 or greater. The above described alkenylated toluenediamines have been found to be well suited as antioxidants and as tri-and tetra functional chain extenders in forming polyurethane/urea elastomers systems and for providing pendant unsaturation for post curing and polymerization.

  本发明涉及一类至少有一个烯基与胺基正交的烯化甲苯二胺。更具体地说，这些甲苯二胺由式表示： 其中 R1、R2、R3、R4 和 Rs 为氢。C1-3脂肪族、苯基、卤素或烷氧基，或 R2 和 R4 或 Rs 通过亚烷基-(CH2)y-桥接，其中 y=2 至 5，且 x 为 1 或 2，条件是在所述式中，R1、R2、R3、R4 或 R5 中至少有一个是 C1 或更大。 已发现上述烯基化甲苯二胺非常适合作为抗氧化剂和三官能和四官能链延伸剂，用于形成聚氨酯/尿素弹性体体系，并为后固化和聚合提供悬垂不饱和度。
• Diamino-beta-alkylstyrenes for use in preparing polyurethane/urea systems
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0272650A1

  公开（公告）日：1988-06-29

  This invention relates to a class of alkenylated toluenediamines and phenylenediamines having at least one alkenyl group ortho to an amine group. More particularly the aryldiamines are represented by the formula: wherein R is hydrogen or C₁-C₃ aliphatic, R₁ is hydrogen, R₂ is C₂-C₄, and R₁ and R₂ form an alkylene radical (CH₂)y wherein y=3 or 4, and x is one or two. The above described alkenylated aryldiamine, hereafter referred to as diamino-β-alkyl styrenes, have been found to be well suited as antioxidants and as tri-and tetra functional chain extenders in forming polyurethane/urea elastomers systems and for providing pendant unsaturation for post curing and polymerization.

  本发明涉及一类至少有一个烯基与一个胺基正交的烯化甲苯二胺和苯二胺。更具体地说，芳基二胺由式表示： 其中 R 是氢或 C₁-C₃ 脂肪族，R₁ 是氢，R₂ 是 C₂-C₄，R₁ 和 R₂ 形成亚烷基 (CH₂)y 其中 y=3 或 4，x 是 1 或 2。 已发现上述烯基芳基二胺（以下称为二氨基-β-烷基苯乙烯）非常适合用作抗氧化剂和三官能和四官能链延伸剂，以形成聚氨酯/尿素弹性体体系，并为后固化和聚合提供悬垂不饱和度。
• Amino-beta-Alkyl styrenes for use in preparing polyurethane/urea systems and polymers
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0277596A2

  公开（公告）日：1988-08-10

  The invention relates to a class of amino-β-alkyl styrenes and process for producing such styrenes. More particularly, the aminoalkyl styrenes are represented by the formula: wherein R is H or C1-5 alkyl; R₁ is H or C₁, methyl; R₂ is C1-4 alkyl; or R₁ and R₂ are combined as a 5 carbon member ring, x is 1 or 2, and y is 1 or 2 when R is H. The above described amino styrenes have been found to be well suited in forming polyurethane/urea elastomer systems and for providing pendant unsaturation for post curing and polymerization with other monomers.

  本发明涉及一类氨基-β-烷基苯乙烯和生产此类苯乙烯的工艺。 更具体地说，氨基烷基苯乙烯由式表示：其中，R 是 H 或 C1-5 烷基；R₁ 是 H 或 C₁、甲基；R₂ 是 C1-4 烷基；或 R₁ 和 R₂ 组合成一个 5 个碳原子的环，当 R 是 H 时，x 是 1 或 2，y 是 1 或 2。 已发现上述氨基苯乙烯非常适用于形成聚氨酯/尿素弹性体体系，并为后固化和与其他单体聚合提供悬垂不饱和度。