2,2-dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester | 91967-11-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester
• 英文别名: Diethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate
• CAS: 91967-11-2
• 化学式: C₁₁H₁₈O₆
• 分子量: 246.26
• InChiKey: MCNKHXZIPATURB-UHFFFAOYSA-N

物化性质

• 沸点：
  137-139.5 °C(Press: 11 Torr)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester 在 phosphotungstic acid 、 水 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以89%的产率得到Diethyl tartrate
  参考文献：
  名称：

  Useful methods for the synthesis of isopropylidenes and their chemoselective cleavage

  摘要：

  A catalytic amount of phosphotungstic acid (PTA) has been found to be a very effective catalyst for isopropylidenation of 1,2-diols and their deprotection at room temperature. The ease of handling, cost and activity of the catalyst, good to excellent yields and chemoselectivity for deprotection are some of the highlights of the reported method. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.050
• 作为产物：
  描述：

  Diethyl tartrate 、 2,2-二甲氧基丙烷 在 phosphotungstic acid 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以92%的产率得到2,2-dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Useful methods for the synthesis of isopropylidenes and their chemoselective cleavage

  摘要：

  A catalytic amount of phosphotungstic acid (PTA) has been found to be a very effective catalyst for isopropylidenation of 1,2-diols and their deprotection at room temperature. The ease of handling, cost and activity of the catalyst, good to excellent yields and chemoselectivity for deprotection are some of the highlights of the reported method. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.050

文献信息

• Useful Combinations of Monobactam Antibiotics With Beta-Lactamase Inhibitors
  申请人：Desarbre Eric

  公开号：US20100056478A1

  公开（公告）日：2010-03-04

  A pharmaceutically composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).

  一种药物组合物，包括公式（I）的抗生素活性化合物与公式（II）至（XIII）中的β-内酰胺酶抑制剂的组合，对革兰氏阴性菌具有活性，特别是对已经对阿奇霉素、卡鲁莫南和替吉奴等抗生素产生耐药性的细菌具有活性。该组合物还可以包含公式（II）至（XIII）中的另一种β-内酰胺酶抑制剂，特别是公式（V）或公式（VI）的β-内酰胺酶抑制剂。
• USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS
  申请人：Basilea Pharmaceutica AG

  公开号：US20150031662A1

  公开（公告）日：2015-01-29

  A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).

  一种药物组合物，包括式(I)的抗生素活性化合物与式(II)至式(XIII)中的一种β-内酰胺酶抑制剂的组合，对革兰氏阴性菌有活性，特别是对已经对阿奇霉素、卡鲁莫纳和替莫纳等抗生素产生耐药性的细菌有活性。该组合物可以包括另一种式(II)至式(XIII)中的β-内酰胺酶抑制剂，特别是式(V)或式(VI)的β-内酰胺酶抑制剂。
• Smoking composition containing a tartrate salt flavorant-release additive
  申请人：Philip Morris Products Inc.

  公开号：EP0501645B1

  公开（公告）日：1997-01-15
• TODA, FUMIO;TANAKA, KOITI
  作者：TODA, FUMIO、TANAKA, KOITI

  DOI：——

  日期：——
• YAMASHITA, JUNZO;MINAGAWA, MASAAKI;SONOBE, AKIHIRO;OHASHI, SHOICHI;KAWAMU+, CHEM. LETT., 1982, N 9, 1409-1412
  作者：YAMASHITA, JUNZO、MINAGAWA, MASAAKI、SONOBE, AKIHIRO、OHASHI, SHOICHI、KAWAMU+

  DOI：——

  日期：——