7-甲基-7-辛烯酸 | 5212-71-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7-甲基-7-辛烯酸
• 英文名称: 7-methyl-7-octenoic acid
• 英文别名: 7-methyloct-7-enoic acid
• CAS: 5212-71-5
• 化学式: C₉H₁₆O₂
• mdl: MFCD02259908
• 分子量: 156.225
• InChiKey: KNZICJALHORLPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916190090

反应信息

• 作为反应物：
  描述：

  7-甲基-7-辛烯酸 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以98%的产率得到异辛酸
  参考文献：
  名称：

  Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics

  摘要：

  In this paper, 26 natural polymyxin components and a new derivative S-2 were synthesized, and their differences in efficacy and toxicity have been investigated. Almost all of the synthesized components showed strong activity against both susceptible and resistant strains of E. coli, K. pneumoniae, P. aeruginosa, and A. baumannii. The toxicities were obviously different between the components. Only some of the components were tested for toxicity in vivo. Compounds E-2, E-2-Val, A(2), M-2, D-2, and S-2 showed obviously lower renal cytotoxicity and acute toxicity than polymyxins B and E. The in vivo nephrotoxicity of E-2, M-2, and S-2 was similar to that of polymyxin E. Compound S-2, with four positive charges, was especially interesting as it possessed both increased efficacy and decreased toxicity. The SAR and toxicity studies indicated that further structural modification could concentrate on polymyxin S. The results also indicated that S-2 could be a new drug candidate.

  DOI：

  10.1021/acs.jmedchem.7b01367
• 作为产物：
  描述：

  5-methylhex-5-enyl tosylate 生成 7-甲基-7-辛烯酸
  参考文献：
  名称：

  Julia,S.; Gueremy,C., Bulletin de la Societe Chimique de France, 1965, p. 2994 - 3001

  摘要：

  DOI：

文献信息

• A Practical One-Pot Synthesis of Enantiopure Unsymmetrical Salen Ligands
  作者：Michael Holbach、Xiaolai Zheng、Caroline Burd、Christopher W. Jones、Marcus Weck

  DOI：10.1021/jo052614y

  日期：2006.3.31

  A practical, one-pot synthesis of enantiopure unsymmetrical salen ligands is described, using a 1:1:1 molar ratio of a chiral diamine and two different salicylaldehydes. The new synthetic protocol can be readily performed in good yields (60−85%) on a multigram scale with good tolerance toward various functional groups.

  描述了使用1：1：1摩尔比的手性二胺和两种不同的水杨醛的对映纯不对称salen配体的实用的一锅合成方法。新的合成方案可以轻松地以多克规模以高收率（60-85％）进行，并且对各种官能团具有良好的耐受性。
• POLYMERIC SALEN COMPOUNDS AND METHODS THEREOF
  申请人：Zheng Xiaolai

  公开号：US20090030172A1

  公开（公告）日：2009-01-29

  The present disclosure provides a polymerizable compound of the formula (I) where the R 1 , R 2 , R′ 1 , R′ 2 , X 1 to X 8 , Y 1 , Y 2 , M and L have any of values as defined in the specification. The disclosure also provides an oligomer, a homo-polymer, or a co-polymer of compound of the formula (I). The disclosure also provides methods for preparing the compound of the formula (I) and methods for preparing polymers of the compound of the formula (I), and to methods and intermediates useful for preparing them. The disclosure also provides methods for the use of the polymers of formula (I) as chiral catalysts in enantioselective preparative processes.

  本公开提供了式(I)的可聚合化合物，其中R1、R2、R′1、R′2、X1至X8、Y1、Y2、M和L的任何值均如规范中定义。本公开还提供了化合物(I)的寡聚物、同聚物或共聚物。本公开还提供了制备化合物(I)的方法，以及制备化合物(I)的聚合物的方法，以及用于制备它们的方法和中间体。本公开还提供了使用式(I)的聚合物作为手性催化剂在对映选择性制备过程中的方法。
• Electrophoretic Dispersion Liquid and Electrophoretic Display Device
  申请人：Minami Masato

  公开号：US20080136772A1

  公开（公告）日：2008-06-12

  An electrophoretic dispersion liquid for an electrophoretic display apparatus includes a plurality of electrophoretic particles each surface of which is modified by one of a basic group and an acidic group, a liquid for holding said electrophoretic particles to be dispersed therein; and a polydiene, having the other group, dissolved in said liquid.

  一种用于电泳显示装置的电泳分散液，包括多种电泳粒子，每个电泳粒子的表面都被一个基团或一个酸性团修饰，用于容纳所述电泳粒子以分散其中的液体；以及溶解在所述液体中的具有另一种团的聚二烯。
• AGGLUTINATION ENHANCER
  申请人：Yamamoto Naoyuki

  公开号：US20140113311A1

  公开（公告）日：2014-04-24

  The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R 1 represents a hydrogen atom or a methyl group; R 2 and R 3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

  本发明的目的是提供一种凝集增强剂，其显示出比传统的免疫凝集增强剂更优异的凝集增强效果，本发明涉及一种用于免疫凝集测量方法的凝集增强剂，其包括具有以下通式[1]所示的单体单位的聚合物：（其中R1表示氢原子或甲基基团；R2和R3分别独立地表示甲基基团或乙基基团；X表示—NH—或氧原子；n表示1至6的整数；m表示1至3的整数），以及一种免疫凝集测量方法，在上述用于免疫凝集测量方法的凝集增强剂共存的情况下，将针对分析物的抗体或分析物的抗原与分析物接触以引起抗原-抗体反应。
• PROCESS FOR PRODUCING ACID ANHYDRIDE
  申请人：Tokuyama Corporation

  公开号：EP1413572A1

  公开（公告）日：2004-04-28

  According to the present invention there is provided a process for producing an acid anhydride by reacting a carboxylic acid, preferably a carboxylic acid having a polymerizable group, with a sulfonyl halide compound in the presence of a tertiary amine or in the presence of a tertiary amine and an inorganic base, wherein the tertiary amine or the tertiary amine and the inorganic base are used in an amount of 0.9 to 1.2 equivalents relative to the acid generated from the sulfonyl halide compound.

  根据本发明，提供了一种生产酸酐的工艺，其方法是在叔胺存在下或在叔胺和无机碱存在下，使羧酸（最好是具有可聚合基团的羧酸）与磺酰卤化合物反应，其中叔胺或叔胺和无机碱的用量相对于磺酰卤化合物生成的酸为 0.9 至 1.2 个当量。