(2R,3S)-2-[3-(4-ethoxyphenyl)propyl]-3-hydroxybutanedioic acid | 586972-82-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (2R,3S)-2-[3-(4-ethoxyphenyl)propyl]-3-hydroxybutanedioic acid
• 英文别名: 2R-[3-(4-ethoxy-phenyl)-propyl]-3S-hydroxy-succinic acid；2R-[3-(4-ethoxyphenyl)propyl]-3S-hydroxysuccinic acid
• CAS: 586972-82-9
• 化学式: C₁₅H₂₀O₆
• 分子量: 296.32
• InChiKey: ANGRRXQOHBNHOK-OLZOCXBDSA-N

物化性质

• 沸点：
  476.7±45.0 °C(Predicted)
• 密度：
  1.272±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,3S)-2-[3-(4-ethoxyphenyl)propyl]-3-hydroxybutanedioic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 copper dichloride 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 16.0h， 生成 2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-5-(4-ethoxy-phenyl)-pentanoic acid pentafluorophenyl ester
  参考文献：
  名称：

  [EN] METALLOPROTEINASE INHIBITORS
  [FR] INHIBITEURS DE METALLOPROTEINASES

  摘要：

  化合物的结构式（IA）或（IB）；其中，W代表HO(C=0)-，HONH(C=0)-或H(C=0)N(OH)-；X代表-O-或-S-；而R1、R2和R3如描述和权利要求中所定义的，是基质金属蛋白酶，特别是MMP9和/或MMP12的抑制剂。

  公开号：

  WO2004101537A1
• 作为产物：
  描述：

  2R-[3-(4-ethoxy-phenyl)-propyl]-3S-hydroxy-succinic acid diisopropylester 在 sodium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 16.0h， 以85%的产率得到(2R,3S)-2-[3-(4-ethoxyphenyl)propyl]-3-hydroxybutanedioic acid
  参考文献：
  名称：

  [EN] DERIVATIVES OF HYDROXAMIC ACID AS METALLOPROTEINASE INHIBITORS
  [FR] DERIVES D'ACIDE HYDROXAMIQUE UTILISES COMME INHIBITEURS DE METALLOPROTEINASES

  摘要：

  式(I)的化合物是基质金属蛋白酶的抑制剂，并可用于治疗纤维化疾病、多发性硬化症、肺气肿、支气管炎和哮喘等疾病：式(I)中Ar代表可选择地取代的芳基、杂环芳基、C3-C8环烷基或杂环烷基基团；R代表氢或C1-C6烷基，或C3-C6环烷基；Alk代表二价的C1-C5烷基或C2-C5烯基基团；R1和R2与它们连接的氮原子一起形成第一杂环烷基环，该环可选择地与第二个C3-C8环烷基或杂环烷基环融合，所述的第一和第二环可选择地被至少一个式(II)的基团取代：式(II)中m、p和n独立地为0或1；Z代表氢，或由5至7个环原子组成的可选择地取代的碳环或杂环环，该环可选择地与另一个由5至7个环原子组成的可选择地取代的碳环或杂环环融合；Alk1和Alk2独立地代表可选择地取代的二价的C1-C3烷基基团；X代表-0-、-S-、-S(O)-、-S(O2)-、-C(=O)-、-NH-、-NR3-、-S(O2)NH-、-S(O2)NR3-、-NHS(O2)-或-NR3S(O2)-，其中R3为C1-C3烷基。

  公开号：

  WO2005019194A1

文献信息

• [EN] DERIVATIVES OF HYDROXAMIC ACID AS METALLOPROTEINASE INHIBITORS<br/>[FR] DERIVES D'ACIDE HYDROXAMIQUE UTILISES COMME INHIBITEURS DE METALLOPROTEINASES
  申请人：VERNALIS OXFORD LTD

  公开号：WO2005019194A1

  公开（公告）日：2005-03-03

  Compounds of formula (I) are inhibitors of matrix metalloproteinases, and are of use in the treatment of, for example fibrotic disease, multiple sclerosis, emphysemia, bronchitis and asthma: formula (I) wherein Ar represents an optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl or heterocycloakyl group; R represents hydrogen or C1-C6 alkyl, or C3-C6 cycloalkyl; Alk represents a divalent C1-C5 alkylene or C2-C5 alkenylene radical; and R1 and R2 taken together with the nitrogen atom to which they are attached form a first heterocycloalkyl ring which is optionally fused to a second C3-C8 cycloalkyl or heterocycloalkyl ring, the said first and second rings being optionally substituted by at least one group of formula (II): formula (II) wherein m, p and n are independently 0 or 1; Z represents, hydrogen, or an optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms which is optionally fused to another optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms; Alk1 and Alk2 independently represent optionally substituted divalent C1-C3 alkylene radicals; X represents -0-, -S-, -S(O)-, -S(O2)-, -C(=O)-, -NH-, -NR3-, -S(O2)NH-, -S(O2)NR3-, -NHS(O2)-, or -NR3S(O2)-, where R3 is C1-C3 alkyl.

  式(I)的化合物是基质金属蛋白酶的抑制剂，并可用于治疗纤维化疾病、多发性硬化症、肺气肿、支气管炎和哮喘等疾病：式(I)中Ar代表可选择地取代的芳基、杂环芳基、C3-C8环烷基或杂环烷基基团；R代表氢或C1-C6烷基，或C3-C6环烷基；Alk代表二价的C1-C5烷基或C2-C5烯基基团；R1和R2与它们连接的氮原子一起形成第一杂环烷基环，该环可选择地与第二个C3-C8环烷基或杂环烷基环融合，所述的第一和第二环可选择地被至少一个式(II)的基团取代：式(II)中m、p和n独立地为0或1；Z代表氢，或由5至7个环原子组成的可选择地取代的碳环或杂环环，该环可选择地与另一个由5至7个环原子组成的可选择地取代的碳环或杂环环融合；Alk1和Alk2独立地代表可选择地取代的二价的C1-C3烷基基团；X代表-0-、-S-、-S(O)-、-S(O2)-、-C(=O)-、-NH-、-NR3-、-S(O2)NH-、-S(O2)NR3-、-NHS(O2)-或-NR3S(O2)-，其中R3为C1-C3烷基。
• Oxa-and thiadiazoles and their use as metalloproteinase inhibitors
  申请人：Ayscough Paul Andrew

  公开号：US20050222189A1

  公开（公告）日：2005-10-06

  Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R 1 , R 2 , and R 3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.

  化合物的公式（IA）或（IB），其中W代表HO（C═O）—，HONH（C═O）—或H（C═O）N（OH）—；X代表—O—或—S—；而R1，R2和R3如说明书和权利要求中所定义的，是基质金属蛋白酶的抑制剂，特别是MMP9和/或MMP12。
• OXA- AND THIADIAZOLES AND THEIR USE AS METALLOPROTEINASE INHIBITORS
  申请人：AYSCOUGH Andrew Paul

  公开号：US20080227833A1

  公开（公告）日：2008-09-18

  Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R 1 , R 2 , and R 3 are as defined in the description and claims, are inhibitors of matrix metal oproteinases, in particular MMP9 and/or MMP12.

  化合物公式（IA）或（IB），其中W代表HO(C═O)—、HONH(C═O)—或H(C═O)N(OH)—；X代表—O—或—S—；而R1、R2和R3如描述和权利要求所定义的那样，是基质金属蛋白酶的抑制剂，特别是MMP9和/或MMP12。
• Derivatives of hydroxamic acid as metalloproteinase inhibitors
  申请人：Pain Gilles

  公开号：US20060281920A1

  公开（公告）日：2006-12-14

  Compounds of formula (I) are inhibitors of matrix metalloproteinases, and are of use in the treatment of, for example fibrotic disease, multiple sclerosis, emphysemia, bronchitis and asthma: formula (I) wherein Ar represents an optionally substituted aryl, heteroaryl, C 3 -C 8 cycloalkyl or heterocycloakyl group; R represents hydrogen or C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl; Alk represents a divalent C 1 -C 5 alkylene or C 2 -C 5 alkenylene radical; and R 1 and R 2 taken together with the nitrogen atom to which they are attached form a first heterocycloalkyl ring which is optionally fused to a second C 3 -C 8 cycloalkyl or heterocycloalkyl ring, the said first and second rings being optionally substituted by at least one group of formula (II): formula (II) wherein m, p and n are independently 0 or 1; Z represents, hydrogen, or an optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms which is optionally fused to another optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms; Alk 1 and Alk 2 independently represent optionally substituted divalent C 1 -C 3 alkylene radicals; X represents —0—, —S—, —S(O)—, —S(O 2 )—, —C(═O)—, —NH—, —NR 3 —, —S(O 2 )NH—, —S(O 2 )NR 3 —, —NHS(O 2 )—, or —NR 3 S(O 2 )—, where R 3 is C 1 -C 3 alkyl.

  公式（I）的化合物是基质金属蛋白酶抑制剂，可用于治疗纤维化疾病、多发性硬化症、肺气肿、支气管炎和哮喘等疾病：公式（I）其中，Ar代表可选取代的芳基、杂芳基、C3-C8环烷基或杂环烷基；R代表氢或C1-C6烷基，或C3-C6环烷基；Alk代表二价的C1-C5烷基或C2-C5烯基基团；R1和R2与它们所连接的氮原子一起形成第一杂环烷基环，该环可选地融合到第二个C3-C8环烷基或杂环烷基环上，所述第一和第二环可选地被至少一个公式（II）的基团取代：公式（II）其中，m、p和n独立地为0或1；Z代表氢，或由5至7个环原子组成的可选取代的碳环或杂环，该环可选地与另一个由5至7个环原子组成的可选取代的碳环或杂环融合；Alk1和Alk2独立地代表可选取代的二价C1-C3烷基基团；X代表—O—、—S—、—S(O)—、—S(O2)—、—C(═O)—、—NH—、—NR3—、—S(O2)NH—、—S(O2)NR3—、—NHS(O2)—或—NR3S(O2)—，其中R3为C1-C3烷基。
• N-Hydroxyamide Derivatives and Use Thereof
  申请人：Swinnen Dominique

  公开号：US20080021028A1

  公开（公告）日：2008-01-24

  The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

  本发明涉及公式（I）的N-羟基酰胺衍生物及其用途，特别用于治疗和/或预防自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸系统疾病和纤维化，包括多发性硬化症、关节炎、肺气肿、慢性阻塞性肺疾病、肝脏和肺纤维化。