1-methoxy-1-phenoxypropane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-methoxy-1-phenoxypropane
• 英文别名: 1-Methoxypropoxybenzene
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: JMQMYOILSJWVRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 烯丙基苯基醚 在 dicobalt octacarbonyl 、 一氧化碳 、 氢气 作用下， 170.0 ℃ 、6.89 MPa 条件下， 反应 0.5h， 生成 2,2-二甲氧基丙烷 、 1-methoxy-1-phenoxypropane
  参考文献：
  名称：

  A facile synthesis of acetals and aldehydes from allylic ethers catalyzed by cobalt compounds

  摘要：

  Octacarbonyldicobalt has been found to be a very effective catalyst for both converting allylic ethers to their corresponding acetals in the presence of an alcohol and hydrolyzing allylic ethers to aldehydes. High yields(> 95%) were obtained in a very short reaction time under mild carbon monoxide pressure. Iron pentacarbonyl was also found to be an active catalyst but less effective than Co-2(CO)(8).

  DOI：

  10.1016/0022-328x(94)05277-i

文献信息

• PROCESS FOR PRODUCING ALISKIREN
  申请人：Chemo Iberica, S.A.

  公开号：EP2576500A2

  公开（公告）日：2013-04-10
• US4404354A
  申请人：——

  公开号：US4404354A

  公开（公告）日：1983-09-13
• [EN] PROCESS FOR PRODUCING ALISKIREN<br/>[FR] PROCÉDÉ DE PRODUCTION D'ALISKIREN
  申请人：CHEMO IBERICA SA

  公开号：WO2011151442A2

  公开（公告）日：2011-12-08

  A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.
• A facile synthesis of acetals and aldehydes from allylic ethers catalyzed by cobalt compounds
  作者：Biau-Hung Chang

  DOI：10.1016/0022-328x(94)05277-i

  日期：1995.4

  Octacarbonyldicobalt has been found to be a very effective catalyst for both converting allylic ethers to their corresponding acetals in the presence of an alcohol and hydrolyzing allylic ethers to aldehydes. High yields(> 95%) were obtained in a very short reaction time under mild carbon monoxide pressure. Iron pentacarbonyl was also found to be an active catalyst but less effective than Co-2(CO)(8).