[(1S)-1-[4-(benzenesulfonyloxy)phenyl]but-3-enyl] 3-[4-(benzenesulfonyloxy)phenyl]propanoate | 886204-68-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S)-1-[4-(benzenesulfonyloxy)phenyl]but-3-enyl] 3-[4-(benzenesulfonyloxy)phenyl]propanoate
• CAS: 886204-68-8
• 化学式: C₃₁H₂₈O₈S₂
• 分子量: 592.691
• InChiKey: PEWOQNJSXKNJSL-PMERELPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  41
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [(1S)-1-[4-(benzenesulfonyloxy)phenyl]but-3-enyl] 3-[4-(benzenesulfonyloxy)phenyl]propanoate 在 N-溴代丁二酰亚胺(NBS) 、 18-冠醚-6 、 三氟化硼乙醚 、 potassium hydride 、 镍 、 二异丁基氢化铝 、 碳酸氢钠 、 potassium carbonate 、 氟化氢吡啶 、 苯基锂 、 苯硫酚 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， -78.0~50.0 ℃ 、413.68 kPa 条件下， 反应 55.63h， 生成 epi-calyxin F
  参考文献：
  名称：

  Synthesis and Structure Revision of Calyxin Natural Products

  摘要：

  Tandem Prins cyclization and Friedel-Crafts reaction with an electron-rich aromatic ring were used to prepare the core structures of calyxin natural products. The proposed structure of epicalyxin F was prepared and shown to be incorrect. Several calyxin natural products, including calyxin F and L, were synthesized, and the structures were reassigned on the basis of NMR data and synthetic correlations.

  DOI：

  10.1021/jo060094g
• 作为产物：
  描述：

  对羟基苯丙酸 在 4-二甲氨基吡啶 、 氢氧化钾 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 20.0h， 生成 [(1S)-1-[4-(benzenesulfonyloxy)phenyl]but-3-enyl] 3-[4-(benzenesulfonyloxy)phenyl]propanoate
  参考文献：
  名称：

  Synthesis and Structure Revision of Calyxin Natural Products

  摘要：

  Tandem Prins cyclization and Friedel-Crafts reaction with an electron-rich aromatic ring were used to prepare the core structures of calyxin natural products. The proposed structure of epicalyxin F was prepared and shown to be incorrect. Several calyxin natural products, including calyxin F and L, were synthesized, and the structures were reassigned on the basis of NMR data and synthetic correlations.

  DOI：

  10.1021/jo060094g

文献信息

• Synthesis and Structure Revision of Calyxin Natural Products
  作者：Xia Tian、James J. Jaber、Scott D. Rychnovsky

  DOI：10.1021/jo060094g

  日期：2006.4.1

  Tandem Prins cyclization and Friedel-Crafts reaction with an electron-rich aromatic ring were used to prepare the core structures of calyxin natural products. The proposed structure of epicalyxin F was prepared and shown to be incorrect. Several calyxin natural products, including calyxin F and L, were synthesized, and the structures were reassigned on the basis of NMR data and synthetic correlations.