2-benzyl-1,3-diphenylpropene | 50485-27-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-benzyl-1,3-diphenylpropene
• 英文别名: 2-benzyl-1,3-diphenyl-1-propene；2-benzyl-1,3-diphenylprop-2-ene；2-Benzyl-1,3-diphenyl-propen；1,3-Diphenyl-2-benzylpropene；(2-benzyl-3-phenylprop-1-enyl)benzene
• CAS: 50485-27-3
• 化学式: C₂₂H₂₀
• 分子量: 284.401
• InChiKey: IXURBHQHNDAKPW-UHFFFAOYSA-N

物化性质

• 熔点：
  29-30 °C
• 沸点：
  231-232 °C(Press: 11 Torr)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-benzyl-1,3-diphenylpropene 在 正丁基锂 、 四甲基乙二胺 作用下， 以 正己烷 为溶剂， 反应 16.0h， 生成 1,3-diphenyl-1,3-bis(trimethylsilyl)-2-benzylidene-1-propane
  参考文献：
  名称：

  Reactions of the Lithium Salts of the Tribenzylidenemethane Dianion, Diphenylacetone Dianion, and Related Compounds

  摘要：

  Potentially synthetically useful reactions of the dilithium salts of the title dianions have been investigated, Electrophilic quenching with a variety of reagents usually leads to the expected products in good yield. Quenching the diphenylacetone dianion with 1 equiv of trimethylchlorosilane, however, gives a good yield of 1,3-diphenylallene obtained by formal elimination of a trimethylsiloxy anion from an intermediate monoquenched monoanion salt. NMR studies, however, do not reveal the intermediacy of the 1,3-diphenyl-2-(trimethylsiloxy)allyl anion but rather suggest that the initial reaction site is at carbon, rather than oxygen, Oxidation of the dianions leads either to ring closure or dimerization for the tribenzylidenemethane dianion and to dimerization for the diphenylacetone dianion. The dimerization reactions are stereospecific, both with respect to the two new stereocenters produced and for the double bonds of the bis-silyl enol ether products if the dimeric bis-enolate dianion products are quenched with trimethylchlorosilane.

  DOI：

  10.1021/jo971113c
• 作为产物：
  描述：

  溴甲苯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 甲苯 为溶剂， 反应 4.5h， 生成 2-benzyl-1,3-diphenylpropene
  参考文献：
  名称：

  支链烷基二苯基膦氧化物的锂化反应性和选择性–邻官能化芳基膦氧化物的简单通用方法

  摘要：

  烷基二苯基膦氧化物通常用烷基锂试剂进行α-去质子化。在此，对差异支化的烷基二苯基膦氧化物的锂化进行了研究，发现了多种多样但可预测的反应性。γ-支链衍生物离岗选择性定向邻-metalation使用（DOM）丁基锂和TMEDA作为添加剂。随着γ支化度的降低，α锂化变得占主导地位。的邻-phosphinoyllithium中间体受官能化和C  C键形成反应，从而提供了一种方便的方法，以新的氧化膦和膦-硼烷复合物，其具有用于一种方法来用于催化新配体的潜力。

  DOI：

  10.1002/adsc.201400861

文献信息

• Ethics and Foreign Policy: The Antinomies of New Labour's ‘Third Way’ in Sub-Saharan Africa
  作者：Rita Abrahamsen、Paul Williams

  DOI：10.1111/1467-9248.00312

  日期：2001.6

  This article explores how New Labour has attempted to implement its ideas about a ‘third way’ foreign policy in sub-Saharan Africa. Through an examination of British foreign policy practices, we explore whether New Labour has succeeded in finding a ‘third way’ between traditional views of socialism and capitalism in Africa. In particular, the article focuses on New Labour's attempts to build peace, prosperity and democracy on the African continent. We conclude that although New Labour's claims to add an ‘ethical dimension’ to foreign policy have succeeded in giving Britain a higher profile in the international arena, the implementation of such a policy is intrinsically difficult. These difficulties in turn arise from the antinomies embodied in New Labour's policy, or more specifically from the tension between the liberal internationalism of the third way and traditional concerns for the national interest, as well as the contradictions inherent in a commitment to both political and economic liberalism.

  这篇文章探讨了新工党如何试图在撒哈拉以南非洲实施其关于“第三条道路”外交政策的想法。通过对英国外交政策实践的审查，我们探讨新工党是否成功地在非洲传统社会主义和资本主义观念之间找到了一种“第三条道路”。特别是，文章关注新工党在非洲大陆上建立和平、繁荣和民主的努力。我们得出结论，尽管新工党声称在外交政策中增加了“道德维度”成功地使英国在国际舞台上更加引人注目，但这种政策的实施本质上是困难的。这些困难反过来源于新工党政策所体现的矛盾，更具体地说，源于第三条道路的自由国际主义与对国家利益的传统关注之间的紧张关系，以及对政治和经济自由主义的承诺中固有的矛盾。
• Alkene synthesis: elimination of arenesulfinic acid from alkyl aryl sulfones using potassium trimethylsilanolate as base
  作者：Charles A.G. Baker-Glenn、Anthony G.M. Barrett、Andrew A. Gray、Panayiotis A. Procopiou、Mark Ruston

  DOI：10.1016/j.tetlet.2005.08.097

  日期：2005.10

  The use of potassium trimethylsilanolate as base to induce elimination of potassium arenesulfinate from alkyl aryl sulfones to produce E-alkenes is described. The reaction was appropriate for substrates containing a benzyl or allyl group α to the sulfone residue.

  描述了使用三甲基硅烷醇钾作为碱以诱导从烷基芳基砜中消除芳烃亚磺酸钾以产生E-烯烃。该反应适合于在砜残基上含有苄基或烯丙基α的底物。
• 신규한 비닐벤젠 포함 화합물, 이를 이용한 감광성 포토레지스트 조성물
  申请人：Skin n Skin Co., Ltd. 주식회사 스킨앤스킨(120070435418) Corp. No ▼ 131111-0165843BRN ▼129-81-98293

  公开号：KR20170007642A

  公开（公告）日：2017-01-19

  (A) 광경화성 화합물 및 하기 화학식 1의 구조를 갖는 (B) 비닐벤젠 포함 모노머를 포함하는 광경화 조성물이 제공된다. <화학식 1> 상기 식에서, X, R1, R2, R3, L, L1, L2 및 L3은 전술하여 정의된 바와 같다.

  提供了一种光固化组合物，该组合物包含(A)光固化化合物和(B)具有下式1结构的含乙烯基苯单体。<方案 1>在上式中，X、R1、R2、R3、L、L1、L2 和 L3 如上定义。
• Synthesis, Structural Characterization, and Reactivity of Zirconium Complexes Containing Trimethylenemethane-Based Ligands
  作者：George Rodriguez、Guillermo C. Bazan

  DOI：10.1021/ja962545s

  日期：1997.1.1

  General synthetic routes to zirconium metallocene-like complexes containing derivatives of the dianionic trimethylenemethane (TMM) ligand are presented. One approach consists of reacting the dilithium salts of TMM, tribenzylidenemethane (TBM), tert-butyltribenzylidenemethane (t-Bu-TBM), and dibenzylidenemethylenemethane (DBM) with either Cp*ZrCl3 or CpZrCl3(DME). In the case of the small TMM fragment

  介绍了含有双阴离子三亚甲基甲烷 (TMM) 配体衍生物的锆金属茂类配合物的一般合成路线。一种方法包括使 TMM、三亚苄基甲烷 (TBM)、叔丁基三亚苄基甲烷 (t-Bu-TBM) 和二亚苄基亚甲基甲烷 (DBM) 的二锂盐与 Cp*ZrCl3 或 CpZrCl3(DME) 反应。在小 TMM 片段的情况下，产物是两性离子 Cp*(TMM)Zr(μ-Cl)2Li(TMEDA) (1)。较大的 TMM 衍生物产生离散的盐，例如 [Cp*(TBM)ZrCl2][Li(TMEDA)2] (2)、[Cp(TBM)ZrCl2][Li(TMEDA)2] (3)、[Cp(t- Bu-TBM)ZrCl2][Li(TMEDA)2] (4)、[Cp*(t-Bu-TBM)ZrCl2][Li(TMEDA)2] (5) 和 [Cp*(exo-endo-DBM) )ZrCl2][Li(TMEDA)2] (6)。TBM(
• Metal-free highly chemo-selective bisphosphorylation and deoxyphosphorylation of carboxylic acids
  作者：Liguang Gan、Tianhao Xu、Qihang Tan、Mengjie Cen、Lingling Wang、Jingwei Zhao、Kuang Liu、Long Liu、Wen-Hao Chen、Li-Biao Han、Jacek E. Nycz、Tieqiao Chen

  DOI：10.1039/d3sc01148h

  日期：——

  route for carboxylic acid conversion as the alkyl source, enabling highly efficient and practical synthesis of the corresponding value-added organophosphorus compounds with high chemo-selectivity and wide substrate scope, including the late modification of complex APIs (active pharmaceutical ingredients). Moreover, this reaction also indicates a new strategy for converting carboxylic acids into alkenes

  羧酸在天然和合成世界中都很容易获得。将它们直接用于制备有机磷化合物将极大地促进有机磷化学的发展。在这份手稿中，我们描述了一种在无过渡金属反应条件下的新颖实用的磷酸化反应，该反应可以通过双磷酸化选择性地将羧酸转化为含 P-C-O-P 基序的化合物，并通过脱氧磷酸化转化为苄基磷化合物。该策略为羧酸转化为烷基源提供了一条新途径，能够高效实用地合成具有高化学选择性和广泛底物范围的相应增值有机磷化合物，包括复杂 API（活性药物成分）的后期修饰。此外，该反应还表明了一种通过将这项工作与随后的 WHE 反应与酮和醛相结合，将羧酸转化为烯烃的新策略。我们预计这种转化羧酸的新模式将在化学合成中得到广泛应用。