5-甲苯基-1-(四氢-2H-吡喃-2-基)-1H-吡唑-3-胺 | 1028363-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-甲苯基-1-(四氢-2H-吡喃-2-基)-1H-吡唑-3-胺
• 英文名称: 5-tolyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-amine
• 英文别名: 5-p-tolyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-amine；5-(4-methylphenyl)-1-(oxan-2-yl)pyrazol-3-amine
• CAS: 1028363-01-0
• 化学式: C₁₅H₁₉N₃O
• 分子量: 257.335
• InChiKey: PVKACZCPSPNZPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  53.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-甲苯基-1-(四氢-2H-吡喃-2-基)-1H-吡唑-3-胺 、 草酰氯单乙酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以57%的产率得到ethyl 2-oxo-2-(1-(tetrahydro-2H-pyran-2-yl)-5-p-tolyl-1H-pyrazol-3-ylamino)acetate
  参考文献：
  名称：

  NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS

  摘要：

  本发明涉及通式（I）的化合物，其中（式2）独立表示单键或双键，表示连接基团A和A'各自独立是5-至7-成员杂环环，其中杂环环A和A'可以选择性地被一个或多个取代基取代，所述取代基可从C1-6烷基，C3-6环烷基，可选择性取代的苯基，可选择性取代的杂环烷基，C1-4烷基烯基（可选择性取代的苯基）和C1-4烷基烯基（可选择性取代的杂环基）中选择，或者两个取代基可以连接形成一个可选择性取代的饱和、不饱和或芳香的5-至7-成员环，其与杂环环A或A'融合，杂环环A和A'除了包含单位X、X'、Y和Y'外，还可以包含一个或多个来自N、NR、S和Ol的杂原子，其中R从H和C1-4烷基中选择；单位X和X'各自独立地是H键受体；单位Y和Y'各自独立地是H键供体。通式（I）的化合物可用于治疗与淀粉样蛋白相关的一类疾病和异常，如阿尔茨海默病，以及与淀粉样蛋白相关的疾病或病况。本发明的化合物还可用于治疗与视觉系统组织中病理异常/变化相关的眼部疾病。

  公开号：

  US20100144793A1
• 作为产物：
  描述：

  C₁₇H₂₁N₃O₂ 、 N-(5-tolyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)acetamide 在 氢氧化钾 、 乙醇 、 水 作用下， 反应 16.0h， 生成 C₁₅H₁₉N₃O 、 5-甲苯基-1-(四氢-2H-吡喃-2-基)-1H-吡唑-3-胺
  参考文献：
  名称：

  WO2008/61795

  摘要：

  公开号：

文献信息

• N-(METHYL) -1H-PYRAZOL-3-AMINE, N-(METHYL)-PYRIDIN-2-AMINE AND N-(METHYL)-THIAZOL-2-AMINE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS, LIKE E.G. ALZHEIMER'S
  申请人：Froestl Wolfgang

  公开号：US20100183513A1

  公开（公告）日：2010-07-22

  The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating, or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

  本发明涉及式（II）的新化合物，可用于治疗与淀粉样蛋白相关的一组紊乱和异常，如阿尔茨海默病，以及与淀粉样蛋白类似的蛋白质相关的疾病或病况。本发明的化合物还可用于治疗与视觉系统组织的病理性异常/变化相关的眼部疾病。本发明还涉及包含这些化合物的制药组合物，并且涉及使用这些化合物制备用于治疗或预防与淀粉样和/或淀粉样类似蛋白质相关的疾病或病况的药物。还公开了一种治疗或预防与淀粉样和/或淀粉样类似蛋白质相关的疾病或病况的方法。
• NOVEL COMPOUND FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS
  申请人：FROESTL Wolfgang

  公开号：US20120309791A1

  公开（公告）日：2012-12-06

  The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating, or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed

  本发明涉及公式（II）的新化合物，可用于治疗与淀粉样蛋白相关的一组疾病和异常，例如阿尔茨海默病，以及与淀粉样蛋白类似蛋白质相关的疾病或病况。本发明的化合物还可用于治疗与视觉系统组织病理异常/变化相关的眼部疾病。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物制备治疗或预防与淀粉样和/或淀粉样类似蛋白质相关的疾病或病况的药物的用途。还公开了一种治疗或预防与淀粉样和/或淀粉样类似蛋白质相关的疾病或病况的方法。
• N-(methyl)-pyridin-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins
  申请人：AC Immune S.A.

  公开号：EP2108644A1

  公开（公告）日：2009-10-14

  The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

  本发明涉及可用于治疗与淀粉样蛋白相关的一组疾病和异常（如阿尔茨海默病）以及与淀粉样蛋白相关的疾病或病症的新型化合物。本发明的化合物还可用于治疗与视觉系统组织的病理异常/变化有关的眼部疾病。本发明进一步涉及包含这些化合物的药物组合物，以及这些化合物用于制备治疗或预防与淀粉样蛋白和/或淀粉样蛋白相关的疾病或病症的药物。还公开了一种治疗或预防与淀粉样蛋白和/或淀粉样蛋白相关的疾病或病症的方法。
• N-(METHYL)-1H-PYRAZOL-3-AMINE, N-(METHYL)-PYRIDIN-2-AMINE AND N-(METHYL)-THIAZOL-2-AMINE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS, LIKE E.G. ALZHEIMER'S
  申请人：AC Immune S.A.

  公开号：EP2102165A2

  公开（公告）日：2009-09-23
• N-(Methyl)-pyridin-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins
  申请人：AC Immune S.A.

  公开号：EP2108644B1

  公开（公告）日：2016-07-20