<1-Methyl-2-(3,4-methylendioxy-phenyl)-aethylamino>-3,4-dihydroxy-acetophenon

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <1-Methyl-2-(3,4-methylendioxy-phenyl)-aethylamino>-3,4-dihydroxy-acetophenon
• 英文别名: 2-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamino)-1-(3,4-dihydroxy-phenyl)-ethanone；2-(2-Benzo[1,3]dioxol-5-yl-1-methyl-aethylamino)-1-(3,4-dihydroxy-phenyl)-aethanon；2-[1-(1,3-Benzodioxol-5-yl)propan-2-ylamino]-1-(3,4-dihydroxyphenyl)ethanone；2-[1-(1,3-benzodioxol-5-yl)propan-2-ylamino]-1-(3,4-dihydroxyphenyl)ethanone
• 化学式: C₁₈H₁₉NO₅
• 分子量: 329.353
• InChiKey: GZQVJINXJOEULQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  替苯丙胺 、 3,4-二羟基-2'-氯苯乙酮 在 乙醇 作用下， 生成 <1-Methyl-2-(3,4-methylendioxy-phenyl)-aethylamino>-3,4-dihydroxy-acetophenon
  参考文献：
  名称：

  Bronchodilators, N-Substituted Derivatives of 1-(3',4'-Dihydroxyphenyl)-2-aminoethanol (Arterenol)

  摘要：

  DOI：

  10.1021/ja01641a010

文献信息

• CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS
  申请人：EMORY UNIVERSITY

  公开号：US20140329907A1

  公开（公告）日：2014-11-06

  Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods, compositions, and compounds for the treatment of disorders including neurological disorders, neuropsychiatric disorders, and metabolic disorders are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes administering to the subject a therapeutically effective amount of the described compounds. A further method of promoting neuroprotection in a subject also is provided, which includes administering to the subject a therapeutically effective amount of the described compounds.

  提供了与激活TrkB受体相关的新型化合物、组合物和方法。这些方法包括在体内或体外给予含有儿茶酚背骨的化合物及其药学上可接受的盐、前药和衍生物的治疗有效量。具体而言，提供了用于治疗神经系统疾病、神经精神疾病和代谢性疾病的方法、组合物和化合物。例如，提供了一种用于治疗或减少受试者患抑郁症、焦虑症或肥胖症的风险的第一种方法，包括向受试者给予所述化合物的治疗有效量。还提供了一种促进受试者神经保护的方法，包括向受试者给予所述化合物的治疗有效量。
• US9266817B2
  申请人：——

  公开号：US9266817B2

  公开（公告）日：2016-02-23
• Bronchodilators, N-Substituted Derivatives of 1-(3',4'-Dihydroxyphenyl)-2-aminoethanol (Arterenol)
  作者：John H. Biel、Edgar G. Schwarz、Edwin P. Sprengeler、Helen A. Leiser、Harris L. Friedman

  DOI：10.1021/ja01641a010

  日期：1954.6