2-fluoro-6-[(3-methylhept-6-en-1-yn-3-yl)oxy]pyridine | 1594110-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoro-6-[(3-methylhept-6-en-1-yn-3-yl)oxy]pyridine
• CAS: 1594110-07-2
• 化学式: C₁₃H₁₄FNO
• 分子量: 219.259
• InChiKey: ACRJGCZXKYBOAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  22.12
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-fluoro-6-[(3-methylhept-6-en-1-yn-3-yl)oxy]pyridine 、 4-氟苯胺 在 三苯基膦双(三氟甲磺酰亚胺)金 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以85%的产率得到2-(but-3-en-1-yl)-N-(4-fluorophenyl)-2-methyl-3-methylidene-2H,3H,5H-[1,3]oxazolo[3,2-a]pyridin-5-imine
  参考文献：
  名称：

  Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines

  摘要：

  A study of the reaction of easily accessible 2-propynyloxy-6-fluoropyridines with arylamines under gold or silver catalysis is described. It has been shown that two types of isomeric oxazolopyridine imine derivatives, which represent unusual heterocyclic motifs, can be selectively obtained in moderate to excellent yields depending on the nature of the metal employed.

  DOI：

  10.1021/ol500939v
• 作为产物：
  描述：

  2,6-二氟吡啶 、 3-甲基-6-庚烯-1-炔-3-醇 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 以47%的产率得到2-fluoro-6-[(3-methylhept-6-en-1-yn-3-yl)oxy]pyridine
  参考文献：
  名称：

  Divergent Product Selectivity in Gold- versus Silver-Catalyzed Reaction of 2-Propynyloxy-6-fluoropyridines with Arylamines

  摘要：

  A study of the reaction of easily accessible 2-propynyloxy-6-fluoropyridines with arylamines under gold or silver catalysis is described. It has been shown that two types of isomeric oxazolopyridine imine derivatives, which represent unusual heterocyclic motifs, can be selectively obtained in moderate to excellent yields depending on the nature of the metal employed.

  DOI：

  10.1021/ol500939v