3-(N,N-dimethylamino)-1-(3,4-dimethoxyphenyl)propan-1-one | 1568-01-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(N,N-dimethylamino)-1-(3,4-dimethoxyphenyl)propan-1-one
• 英文别名: 1-(3,4-dimethoxyphenyl)-3-(dimethylamino)propan-1-one；1-(3,4-dimethoxy-phenyl)-3-dimethylamino-propan-1-one；1-(3,4-Dimethoxy-phenyl)-3-dimethylamino-propan-1-on；β-Dimethylamino-3.4-dimethoxy-propiophenon；4-(β-Dimethylamino-propionyl)-veratrol
• CAS: 1568-01-0
• 化学式: C₁₃H₁₉NO₃
• mdl: MFCD01116954
• 分子量: 237.299
• InChiKey: HSSNCUJHRGPSFH-UHFFFAOYSA-N

物化性质

• 沸点：
  136 °C(Press: 0.2 Torr)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(N,N-dimethylamino)-1-(3,4-dimethoxyphenyl)propan-1-one 在 Pd-BaSO₄ 、 1,2,3,4-四氢萘 作用下， 生成 1-(3,4-二甲氧基苯基)-1-丙酮
  参考文献：
  名称：

  Über eine Darstellungsmethode von Aryl-äthylketonen durch hydrierende thermische Zersetzung von 1,3-Ketobasen

  摘要：

  DOI：

  10.1002/ardp.19432810405
• 作为产物：
  描述：

  盐酸二甲胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 聚合甲醛 、 乙醇 作用下， 生成 3-(N,N-dimethylamino)-1-(3,4-dimethoxyphenyl)propan-1-one
  参考文献：
  名称：

  Mannich; Lammering, Chemische Berichte, 1922, vol. 55, p. 3518

  摘要：

  DOI：

文献信息

• Alkylenepoly(aralkylamines) and the salts thereof
  申请人：ENDO LABORATORIES INC.

  公开号：US03929887A1

  公开（公告）日：1975-12-30

  Novel alkylenepoly(aralkylamines) and related compounds, the pharmaceutically acceptable acid addition salts thereof and compositions containing such substances have been found to exhibit high sustained and useful levels of fibrinolytic acitivity in mammals.

  新型的烷基聚（芳基胺）和相关化合物，其药学上可接受的酸盐加成物以及含有这些物质的组合物已被发现在哺乳动物中表现出高持续和有用的纤溶活性。
• Therapeutic Agent for Type 2 Diabetes
  申请人：NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY

  公开号：US20160060235A1

  公开（公告）日：2016-03-03

  An object of the present invention is to provide a novel therapeutic agent for a patient with type 2 diabetes, a cause of which is the abnormal synthesis of insulin attributed to the abnormal modification of tRNA Lys (UUU) in pancreatic β cells having Cdkal1 gene mutation. The present inventors have used (1) a screening system using E. coli in which correct translation into luciferase requires frameshift resulting from mistranslation during protein translation, (2) a screening system using the pancreatic islet of Langerhans isolated from a pancreatic β cell-specific Cdkal1-deficient mouse, and (3) a screening system using a pancreatic β cell-specific Cdkal1-deficient mouse, and found that a compound represented by any of the following formulas (I) to (III) can serve as a therapeutic agent for a patient with type 2 diabetes with Cdkal1 gene mutation resulting in the reduced ability to secrete insulin.

  本发明的一个目的是为2型糖尿病患者提供一种新型治疗剂，其原因是由于胰岛素的异常合成归因于胰岛β细胞中tRNALys(UUU)的异常修饰，其具有Cdkal1基因突变。本发明者已经使用了（1）使用大肠杆菌的筛选系统，其中正确的翻译成荧光酶需要在蛋白质翻译过程中由于错误翻译而导致的移码，（2）使用从胰岛β细胞特异性Cdkal1缺陷小鼠中分离的Langerhans胰岛的筛选系统，以及（3）使用胰岛β细胞特异性Cdkal1缺陷小鼠的筛选系统，并发现以下任一式（I）至（III）所代表的化合物可以作为一种治疗剂，用于具有Cdkal1基因突变且导致胰岛素分泌能力降低的2型糖尿病患者。
• Dihydropyrazoles
  申请人：Yu Henry

  公开号：US20130172351A1

  公开（公告）日：2013-07-04

  Novel dihydropyrazole derivatives of formula (I) wherein L, R, R 3 , R 4 , R 5 , R 6 , R 7 , X 1 , X 2 , X 3 , X 4 , Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

  公式(I)的新型二氢吡唑衍生物，其中L，R，R3，R4，R5，R6，R7，X1，X2，X3，X4，Y，m和n的含义如权利要求所述，是FSH受体的正向变构调节剂，可用于治疗不孕症等疾病。
• Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol
  作者：Lilian Sibelle Campos Bernardes、Massuo Jorge Kato、Sérgio Albuquerque、Ivone Carvalho

  DOI：10.1016/j.bmc.2006.07.006

  日期：2006.11

  Chagas' disease is endemic in Central and South American countries. Specific chemotherapy with nifurtimox or benznidazole has been recommended for treatment of recent infection but they have limited efficacy. The natural products veraguensin (1) and grandisin (2) have shown potent in vitro activity against trypomastigote parasite (Y strain) with IC50 2.3 mu M (1) and 3.7 mu M (2). We report herein the synthesis and in vitro trypanocidal evaluation of symmetrical and unsymmetrical 1,4-diaryl-1,4-diol derivatives as potential trypanocidal analogs of natural compounds 1 and 2. Among the synthesized products, compounds 1,4-bis-(3,4,5-trimethoxyphenyl)-1,4-butanediol (6a) and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol (6b) showed better activity against Trypanosoma cruzi trypomastigotes with IC50 100 and 105 mu M (Y strain), respectively, and 110 mu M (Bolivia strain) for both compounds. However, the most active compound of this series was 1,4-bis-(3,4-dimethoxyphenyl)butane-1,4-dione (7b) with IC50 10 and 200 mu M against Y and Bolivia strains, respectively. (c) 2006 Elsevier Ltd. All rights reserved.
• Über die Umwandlung von 1,3-Amino-ketonen in 1,4-Nitro-ketone
  作者：Benno Reichert、Heinz Posemann

  DOI：10.1002/ardp.19372750203

  日期：——