1-Methylcyclopentyl phenyl ketone | 17206-29-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methylcyclopentyl phenyl ketone
• 英文别名: α-Methylcyclohexylphenylketon；1-Methyl-cyclopentyl-phenylketon；1-Methylcyclopentylphenylketon；1-Benzoyl-1-methylcyclopentan；(1-Methylcyclopentyl)(phenyl)methanone；(1-methylcyclopentyl)-phenylmethanone
• CAS: 17206-29-0
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: VPQYFDCIAVDTDW-UHFFFAOYSA-N

物化性质

• 沸点：
  147 °C(Press: 17 Torr)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Methylcyclopentyl phenyl ketone 在 copper(l) chloride 作用下， 以 氨 为溶剂， 生成 4-Dimethylamino-1-(1-methyl-cyclopentyl)-1-phenyl-but-2-yn-1-ol
  参考文献：
  名称：

  Libman, N. M.; Kuznetsov, S. G.; Loktionov, S. I., Pharmaceutical Chemistry Journal, 1998, vol. 32, # 12, p. 644 - 648

  摘要：

  DOI：
• 作为产物：
  描述：

  环戊酸 生成 1-Methylcyclopentyl phenyl ketone
  参考文献：
  名称：

  Zwitter annihilation in the halogenation of allylic alkoxides. II. 1-Phenyl-2-methyl-2-cyclohexen-1-ol system

  摘要：

  DOI：

  10.1021/jo00795a031

文献信息

• Modification of photochemical reactivity by zeolites: Cation enhanced α-cleavage of aryl alkyl ketones included in faujasites
  作者：V. Ramamurthy、D.R. Corbin、N.J. Turro、Y. Sato

  DOI：10.1016/s0040-4039(01)93482-3

  日期：1989.1

  The yield of Norrish type I products are significantly enhanced when aryl alkyl ketones are photolyzed in the cages of faujasite type zeolites. Exchangeable cations present within the supercages are suggested to be responsible for such an enhanced α-cleavage.

  当在八面沸石型沸石的笼中光解芳基烷基酮时，Norrish I型产品的收率显着提高。认为存在于超笼中的可交换阳离子是这种增强的α裂解的原因。
• Ketamine Derivatives
  申请人：SLEIGH James Wallace

  公开号：US20150259277A1

  公开（公告）日：2015-09-17

  The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).

  本发明涉及公式（I）的氯胺酮衍生物，包括它们的药物组成物，以及用于治疗疼痛的给药方法，以及它们用于制造治疗疼痛药物的用途。本发明还涉及给予公式（II）的氯胺酮衍生物的方法，用于麻醉和镇静受试者的方法。
• Calas,M. et al., Bulletin de la Societe Chimique de France, 1973, p. 2079 - 2086
  作者：Calas,M. et al.

  DOI：——

  日期：——
• A New Redundant Rearrangement of Aromatic Ring Fused Cyclic α-Hydroxydithiane Derivatives. Synthesis of Aromatic Ring Fused Cyclic 1,2-Diketones with One-Carbon Ring Expansion
  作者：Brindaban C. Ranu、Umasish Jana

  DOI：10.1021/jo990634s

  日期：1999.8.1

  A new reaction involving rearrangement of aromatic ring fused cyclic dithiane alcohol by N-chlorosuccinimide in CH2Cl2-H2O to the corresponding one-carbon ring expanded 1,2-diketone has been developed. A wide range of structurally varied dithiane alcohols have been found to undergo this rearrangement in high yields. The general criteria and reaction mechanism for this rearrangement have also been worked out.
• Hori, Mikio; Kataoka, Tadashi; Shimizu, Hiroshi, Chemical and pharmaceutical bulletin, 1986, vol. 34, # 9, p. 3599 - 3605
  作者：Hori, Mikio、Kataoka, Tadashi、Shimizu, Hiroshi、Imai, Eiji、Iwamura, Tatsunori、Maeda, Kaori

  DOI：——

  日期：——