develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles from simple and inexpensive raw materials. Further diversification of the
在这里,我们使用
丙二腈或
AMBN 作为
氰化剂,开发了有效且实用的方案,用于在有氧条件下,对在邻位带有硝基和甲氧基取代基的芳基
羧酸以及杂芳族
羧酸进行 Cu 介导的脱羧
氰化反应。这些协议涉及从简单且廉价的原材料合成增值芳基腈的经济方法。对 2-
硝基苯腈产品进行了进一步的多样化, 以突出协议的实用性。