2-acetylsalicylic acid chloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetylsalicylic acid chloride
• 英文别名: 2-acetyl-salicyloyl chloride；2-acetylsalicyloyl chloride；6-acetyl-6-hydroxycyclohexa-2,4-diene-1-carbonyl chloride
• 化学式: C₉H₉ClO₃
• 分子量: 200.622
• InChiKey: QDEOLQXBVGPPDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-acetylsalicylic acid chloride 、 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione 在 吡啶 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione
  参考文献：
  名称：

  BIOREDUCTIVE CONJUGATES FOR DRUG TARGETING

  摘要：

  公开号：

  EP0988057B1

文献信息

• Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0825164A2

  公开（公告）日：1998-02-25

  This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

  这项发明涉及一种用于制备酰胺、碳酸酯和磺酰胺组合库的新型溶液相过程。这些库在药物发现中具有实用价值，并用于形成新型检测套件的微孔板组件。
• Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use
  申请人：Bel/Novamann International s.r.o.

  公开号：EP2468741A1

  公开（公告）日：2012-06-27

  The invention relates to novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and solvates and dimers thereof; a process for the preparation of the novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and solvates and dimers thereof; and pharmaceutical compositions comprising the same that are useful for the treatment of various disorders. The quercetin derivatives are shown by formula I and II.

  该发明涉及新型槲皮素衍生物及其药用可接受的盐、水合物、溶剂合物和二聚体；一种制备新型槲皮素衍生物及其药用可接受的盐、水合物、溶剂合物和二聚体的方法；以及包含这些物质的药物组合物，用于治疗各种疾病。槲皮素衍生物的结构由化学式I和II表示。
• Glycerides with anti-inflammatory properties
  申请人：Abbott Laboratories

  公开号：US03988446A1

  公开（公告）日：1976-10-26

  Triglycerides carrying the anti-inflammatory drug moiety in the 2-position and hydrocarbon acyl moieties in the 1- and 3-position exhibit excellent anti-inflammatory properties without causing the side effects often associated with the anti-inflammatory drug itself.

  在三酸甘油酯分子中，将抗炎药物基团置于2号位置，将烃基酰基团置于1号和3号位置，可以展现出优秀的抗炎特性，同时不会引起通常与抗炎药物本身相关的副作用。
• SELENOESTER-CONTAINING COMPOUNDS FOR USE IN THE TREATMENT OF MICROBIAL INFECTIONS OR COLORECTAL CANCER
  申请人：Consejo Superior De Investigaciones Científicas

  公开号：EP3628659A1

  公开（公告）日：2020-04-01

  The invention relates to a compound of formula I for use in the treatment of microbial infections or colorectal cancer, wherein R1 to R4, X, n, p, q, r and s are defined in the description.

  本发明涉及一种化合物I，用于治疗微生物感染或结直肠癌，其中R1到R4，X，n，p，q，r和s在说明中定义。
• Compounds and compositions for delivering active agents
  申请人：EMISPHERE TECHNOLOGIES, INC

  公开号：US20020040061A1

  公开（公告）日：2002-04-04

  Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

  提供用于传递活性剂的化合物和组合物。同时提供了给药和制备方法。