二丁基丙基膦酸酯 | 49552-34-3

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二丁基丙基膦酸酯
• 中文别名: 奥兰西丁中间体
• 英文名称: 3,4-dichlorobenzylamine hydrochloride
• 英文别名: (3,4-dichlorophenyl)methanamine;hydrochloride
• CAS: 49552-34-3
• 化学式: C₇H₇Cl₂N*ClH
• 分子量: 212.506
• InChiKey: RLGVDTCKJKBXOC-UHFFFAOYSA-N

物化性质

• 熔点：
  244 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -1.26
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  二丁基丙基膦酸酯 在 氯化亚砜 、 sodium hydride 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.5h， 生成
  参考文献：
  名称：

  Novel, Highly Potent Aldose Reductase Inhibitors:  (R)-(−)-2-(4-Bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine- 4-spiro-3‘-pyrrolidine-1,2‘,3,5‘-tetrone (AS-3201) and Its Congeners

  摘要：

  A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors (ARIs) on the basis of their abilities to inhibit porcine lens aldose reductase (AR) in vitro and to inhibit sorbitol accumulation in the sciatic nerve of streptozotocin-induced diabetic rats in vivo. Of these compounds, spirosuccinimide-fused tetrahydropyrrolo[1,2-a]pyrazine-1,3-dione derivatives showed significantly potent AR inhibitory activity. In the in vivo activity of these derivatives, 2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo- [1,2-a][1,2a]pyrazine-4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (23t) (SX-3030) showed the best oral activity. The enantiomers of 23t were synthesized, and the biological activities were evaluated. It was found that AR inhibitory activity resides in the (-)-enantiomer 43 (AS-3201), which was 10 times more potent in inhibition of the AR (IC50 = 1.5 x 10(-8) M) and 500 times more potent in the in vivo activity (ED50 = 0.18 mg/kg/day for 5 days) than the corresponding (+)enantiomer 44 (SX-3202): From these results, AS-3201 was selected as the candidate for clinical development. The absolute configuration of AS-3201 was also established to be (R)-form by single-crystal X-ray analysis. In this article we report the preparation and structure-activity relationship (SAR) of tetrahydropyrrolopyrazine derivatives including a novel ARI, AS-3201.

  DOI：

  10.1021/jm9802968
• 作为产物：
  描述：

  3,4-二氯苯腈 在 [Mn(HN(C₂H₄PⁱPr₂)₂)(CO)₂Br] 、 氢气 、 sodium t-butanolate 、 盐酸 作用下， 以 甲苯 、 乙醚 为溶剂， 120.0 ℃ 、5.0 MPa 条件下， 反应 24.0h， 以83%的产率得到二丁基丙基膦酸酯
  参考文献：
  名称：

  定义明确的锰钳络合物选择性催化加氢腈、酮和醛

  摘要：

  氢化构成有机化学中的基本过程，并允许原子高效和清洁的官能团转化。事实上，用分子氢选择性还原腈、酮和醛可以实现有价值的胺和醇的绿色合成。尽管在均相和多相催化方面取得了一个多世纪的发展，但仍在努力创造新的有用和广泛适用的催化剂体系。最近，地球上丰富的金属在这一领域引起了极大的兴趣。在本研究中，我们首次描述了特定分子定义的锰配合物，这些配合物允许各种极性官能团的氢化。在最佳条件下，我们实现了良好的官能团耐受性和工业上重要的底物，例如，

  DOI：

  10.1021/jacs.6b03709

文献信息

• Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications
  作者：Michael C. Van Zandt、Evelyn O. Sibley、Erin E. McCann、Kerry J. Combs、Brenda Flam、Diane R. Sawicki、Al Sabetta、Anne Carrington、Janet Sredy、Eduardo Howard、Andre Mitschler、Alberto D. Podjarny

  DOI：10.1016/j.bmc.2004.07.062

  日期：2004.11

  Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a core template that utilizes an intramolecular hydrogen bond to position the key structural elements of the pharmacophore in a conformation, which promotes

  最近鉴定慢性糖尿病并发症的治疗方法的努力导致发现了一系列新的高效和选择性的（2-芳基氨基甲酰基-苯氧基）乙酸醛糖还原酶抑制剂。化合物类别的特征是核心模板，该模板利用分子内氢键将药效基团的关键结构元件定位在构象中，从而促进了高结合亲和力。铅候选物，例如40，5-氟-2-（4-溴-2-氟-苄硫代氨基甲酰基）-苯氧基乙酸，抑制醛糖还原酶，IC（50）为30 nM，而对醛还原酶的活性低1100倍，是一种与活性醛解毒有关的酶。另外，实施例40在4天STZ诱导的糖尿病大鼠模型中以31mg / kg / d po的ED（50）降低了神经山梨糖醇水平。
• BACTERIOSTATS: V. THE PREPARATION AND BACTERIOSTATIC PROPERTIES OF AMIDINE DERIVATIVES
  作者：D. L. Garmaise、R. W. Kay、R. Gaudry、H. A. Baker、A. F. McKay

  DOI：10.1139/v61-189

  日期：1961.7.1

  A number of polyamidines, N-substituted amidines, and diamidines were prepared for evaluation as bacteriostats. N,N′-Bis-(3,4-dichlorobenzyl)-sebacamidine dihydrochloride was the most active compou...

  制备了许多聚脒、N-取代脒和二脒，用于评价作为抑菌剂。N,N'-双-(3,4-二氯苄基)-癸二脒二盐酸盐是活性最强的化合物...
• Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers
  作者：Xiang Ma、Thong-Yuen Poon、Peter Tsun Hon Wong、Wai-Keung Chui

  DOI：10.1016/j.bmcl.2009.08.052

  日期：2009.10

  the best neuronal sodium binding activity among the four groups of triazines evaluated. Derivatives 4a–4j blocked the sodium channels with IC50 values ranged from 4.0 to 14.7 μM. The result from this study showed that analogues of 2,4-diamino-1,3,5-triazines could be used as leads for the discovery of neuronal sodium channels blockers for managing central nervous system related disorders.

  神经元钠通道阻滞剂会干扰离子通量，并已用于治疗神经性疼痛，癫痫和脑缺血性疾病。在目前的研究中，合成了四组2,4-二氨基-1,3,5-三嗪衍生物，并研究了它们的神经元钠通道结合活性。在四组三嗪中，发现5-Aryl-1,3,5-triazaspiro [5.5] undeca-1,3-diene-2,4-diamines（4a - 4j）具有最佳的神经元钠结合活性。衍生物4a – 4j用IC 50阻断了钠通道值范围为4.0至14.7μM。这项研究的结果表明，2,4-二氨基-1,3,5-三嗪的类似物可以用作发现神经元钠通道阻滞剂以治疗中枢神经系统相关疾病的先导。
• Biguanide derivatives, manufacturing method thereof, and disinfectants
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05376686A1

  公开（公告）日：1994-12-27

  The invention presents a biguanide derivative or its salt expressed by a formula: ##STR1## (where R.sup.1 and R.sup.2 are as defined in Specification), or formula: ##STR2## (where A and R.sup.3 is as defined in specification). This biguanide derivative or its salt is preferably used as the effective amount of a disinfectant for humans, animals, medical appliances, etc.

  该发明提供了一种由以下式子表示的双胍衍生物或其盐：##STR1## （其中R.sup.1和R.sup.2如规范中所定义），或式：##STR2## （其中A和R.sup.3如规范中所定义）。该双胍衍生物或其盐可作为人类、动物、医疗器械等的消毒剂的有效成分。
• PIPETTE TIPS
  申请人：Biotix, Inc.

  公开号：EP3831489A1

  公开（公告）日：2021-06-09

  The present invention relates to a pipette tip comprising a proximal region and a distal region, wherein the proximal region comprises an exterior surface and an annular flange at the proximal terminus of the proximal region, the proximal region comprises a first set of axially oriented ribs and a second set of axially oriented ribs, the ribs of the first set and the second set are circumferentially spaced and alternately spaced around the exterior surface of the proximal region, and ribs of the first set have a maximum thickness greater than the maximum thickness of ribs of the second set.

  本发明涉及一种移液器吸头，包括一个近端区域和一个远端区域，其中近端区域包括一个外表面和一个位于近端区域近端末端的环形凸缘，近端区域包括第一组轴向定向的肋条和第二组轴向定向的肋条，第一组和第二组肋条在近端区域的外表面周向间隔并交替间隔，第一组肋条的最大厚度大于第二组肋条的最大厚度。