2-amino-5-mercapto-s-triazole | 955942-82-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-5-mercapto-s-triazole
• 英文别名: N-amino-1,2,4-triazol thione；2-amino-1H-1,2,4-triazole-5-thione
• CAS: 955942-82-2
• 化学式: C₂H₄N₄S
• 分子量: 116.147
• InChiKey: WAJAYIUXCILUMF-UHFFFAOYSA-N

物化性质

• 沸点：
  190.1±23.0 °C(Predicted)
• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-5-mercapto-s-triazole 在 H₁₄[NaP₅W₃₀O₁₁₀] 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 以57%的产率得到3-巯基-1,2,4-三氮唑
  参考文献：
  名称：

  Deamination of Some N-Amino Nitrogen Heterocycles Using Preyssler’s Anion

  摘要：

  Some N-aminotriazines and -triazoles were treated with Preyssler's anion as catalyst in acetic acid to afford the corresponding deaminated triazines and triazoles. The reaction is suggested to proceed via formation of N-nitrosamines with subsequent N-NO bond cleavage.

  DOI：

  10.1007/s00706-007-0715-1

文献信息

• Cephalosporin derivatives
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US04888332A1

  公开（公告）日：1989-12-19

  The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

  本发明涉及新型头孢菌素衍生物、其制备方法、以新型头孢菌素衍生物作为活性成分的预防和/或治疗传染病的组合物，以及头孢菌素衍生物合成中的中间体化合物和其制备方法。本发明的新型头孢菌素衍生物包含紧缩杂环基团，特别是三唑嘧啶环或噻唑嘧啶环作为头孢菌素骨架的3位取代基，并且在头孢菌素骨架的7位取代基是羟肟基、烷氧基肟基或酰氧基肟基。本发明中含有上述取代基的化合物对革兰氏阴性菌和包括甲氧西林耐药金黄色葡萄球菌在内的革兰氏阳性菌具有强大的抗菌活性。这些化合物对于治疗传染病非常有用。
• Deamination of Some N-Amino Nitrogen Heterocycles Using Preyssler’s Anion
  作者：Majid M. Heravi、Sodeh Sadjadi、Rahim Hekmatshoar、Hossein A. Oskooie、Fatemeh F. Bamoharram

  DOI：10.1007/s00706-007-0715-1

  日期：2008.2

  Some N-aminotriazines and -triazoles were treated with Preyssler's anion as catalyst in acetic acid to afford the corresponding deaminated triazines and triazoles. The reaction is suggested to proceed via formation of N-nitrosamines with subsequent N-NO bond cleavage.