[3,4-bis-(1-ethoxyethoxy)-phenyl]-methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [3,4-bis-(1-ethoxyethoxy)-phenyl]-methanol
• 英文别名: 3,4-bis(2-ethoxyethoxy)phenylmethanol；[3,4-Bis(2-ethoxyethoxy)phenyl]methanol
• 化学式: C₁₅H₂₄O₅
• 分子量: 284.353
• InChiKey: SNSOXEAWDRXVBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [3,4-bis-(1-ethoxyethoxy)-phenyl]-methanol 在 吡啶 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.58h， 生成 (4E)-3-hydroxy-5-phenylpent-4-enoic acid 3,4-bis-(1-ethoxyethoxy)-benzyl ester
  参考文献：
  名称：

  通过三种不同的策略合成新的生物合成重要的二芳基庚烷及其氧杂和氟类似物

  摘要：

  摘要 Wittig、aldol 和 Wittig-Horner 反应已被用于合成新的二芳基庚烷类化合物，它们是植物中苯菲酮生物合成的假定中间体。与其他方法相比，Wittig-Horner 方法是最合适的，并且产生了显着更高的产量。

  DOI：

  10.1081/scc-120016367
• 作为产物：
  描述：

  原儿茶酸 在 lithium aluminium tetrahydride 、 硫酸 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 [3,4-bis-(1-ethoxyethoxy)-phenyl]-methanol
  参考文献：
  名称：

  Synthesis and radical polymerisation of methacrylic monomers with crown ethers or their dipodal counterparts in the pendant structure

  摘要：

  The synthesis and radical polymerisation of methacrylic monomers with benzo-12-crown-4, benzo-15-crown-5, benzo-18-crown-6, and their dipodal counterparts in the ester residue is described. The radical polymerisation of the monomers in solution was carried out at different temperatures, and the polymerisation kinetics curves were obtained by direct measurement of the instantaneous monomer concentrations by nuclear magnetic resonance spectroscopy (NMR). Thus, the polymerisation rate parameter (2fk(p)/(k(t))(1/2)), along with the polymer stereoregularity, were obtained in terms of the molar fractions of meso and racemo diads and of syndiotactic, isotactic and heterotactic triads. The interaction of the polymers with cations was studied using polymer networks as solid phases in the solid-liquid extraction of lanthanide cations from both organic and aqueous media. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2011.06.004

文献信息

• Synthesis and radical polymerisation of methacrylic monomers with crown ethers or their dipodal counterparts in the pendant structure
  作者：Jimena Rey、Félix Clemente García、José Miguel García

  DOI：10.1016/j.reactfunctpolym.2011.06.004

  日期：2011.9

  The synthesis and radical polymerisation of methacrylic monomers with benzo-12-crown-4, benzo-15-crown-5, benzo-18-crown-6, and their dipodal counterparts in the ester residue is described. The radical polymerisation of the monomers in solution was carried out at different temperatures, and the polymerisation kinetics curves were obtained by direct measurement of the instantaneous monomer concentrations by nuclear magnetic resonance spectroscopy (NMR). Thus, the polymerisation rate parameter (2fk(p)/(k(t))(1/2)), along with the polymer stereoregularity, were obtained in terms of the molar fractions of meso and racemo diads and of syndiotactic, isotactic and heterotactic triads. The interaction of the polymers with cations was studied using polymer networks as solid phases in the solid-liquid extraction of lanthanide cations from both organic and aqueous media. (C) 2011 Elsevier Ltd. All rights reserved.
• Synthesis of New Biosynthetically Important Diarylheptanoids and Their Oxa- and Fluoro- Analogues by Three Different Strategies
  作者：Alexander Baranovsky、Bettina Schmitt、Daniel J. Fowler、Bernd Schneider

  DOI：10.1081/scc-120016367

  日期：2003.1.4

  Abstract Wittig, aldol and Wittig-Horner reactions have been used to synthesize new diarylheptanoids, which are putative intermediates in phenylphenalenone biosynthesis in plants. The Wittig-Horner approach was most suitable and gave significantly higher yields in comparison with other methods.

  摘要 Wittig、aldol 和 Wittig-Horner 反应已被用于合成新的二芳基庚烷类化合物，它们是植物中苯菲酮生物合成的假定中间体。与其他方法相比，Wittig-Horner 方法是最合适的，并且产生了显着更高的产量。