tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate | 167486-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate
• 英文别名: N-TERT-BUTOXYCARBONYL-DI(O-BENZYL)SERINOL；tert-butyl N-[1,3-bis(phenylmethoxy)propan-2-yl]carbamate
• CAS: 167486-39-7
• 化学式: C₂₂H₂₉NO₄
• 分子量: 371.477
• InChiKey: ZNZDORGDMAKNOG-UHFFFAOYSA-N

物化性质

• 沸点：
  505.6±50.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate 在 四氯化碳 、 乙酸酐 、 N,N-二异丙基乙胺 、 三苯基膦 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors

  摘要：

  Novel branched isocyanides have been prepared from L-serine and used as building blocks in the Passerini-amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.018
• 作为产物：
  描述：

  N-BOC-O-苄基-L-丝氨酸 在 lithium aluminium tetrahydride 、 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成 tert-butyl (1,3-bis(benzyloxy)propan-2-yl)carbamate
  参考文献：
  名称：

  Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors

  摘要：

  Novel branched isocyanides have been prepared from L-serine and used as building blocks in the Passerini-amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.018

文献信息

• [EN] OPIOID AGONISTS AND USES THEREOF<br/>[FR] AGONISTES OPIOÏDES ET LEURS UTILISATIONS
  申请人：NEKTAR THERAPEUTICS INDIA PVT LTD

  公开号：WO2015079459A1

  公开（公告）日：2015-06-04

  Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

  提供的是化合物，包括公式I的化合物；以及它们的药用可接受盐和溶剂化物。本文所述的化合物与药物发现、药物治疗、生理学、有机化学和聚合物化学等领域有关，并且/或在这些领域有应用。
• Difluoro statone analogs
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US05717093A1

  公开（公告）日：1998-02-10

  This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-viral agents.

  这项发明涉及新型二氟烯酮类似物，以及用于它们制备的过程和中间体，以及它们作为抗病毒剂的用途。
• Total Synthesis of <i>Campylobacter jejuni</i> NCTC11168 Capsular Polysaccharide via the Intramolecular Anomeric Protection Strategy
  作者：Chun-Hong Yeh、Ya-Jou Chang、Tsung-Juin Lin、Cheng-Chung Wang

  DOI：10.1021/jacs.3c00102

  日期：2023.4.26

  diarrhea disease, which is highly fatal to young children in unindustrialized countries. Developing a new therapy is required due to increasing antibiotic resistance. Herein, we described a total synthesis of a C. jejuni NCTC11168 capsular polysaccharide repeating unit containing a linker moiety via an intramolecular anomeric protection (iMAP) strategy. This one-step 1,6-protecting method structured

  空肠弯曲杆菌的感染导致严重的腹泻病，这对未工业化国家的幼儿来说是高度致命的。由于抗生素耐药性增加，需要开发新疗法。在此，我们描述了空肠弯曲杆菌的全合成NCTC11168 荚膜多糖重复单元通过分子内端基异构保护 (iMAP) 策略包含连接部分。这种一步 1,6-保护方法构建了具有挑战性的呋喃糖基半乳糖胺构型，促进了进一步简明的区域选择性保护，并使庚糖合成顺利进行。四糖以[2+1+1]的方式构建。这种复杂的CPS四糖的合成只用了28个步骤，包括所有结构单元的制备、四糖骨架的构建和官能团的转化。
• Opioid agonists and uses thereof
  申请人：Nektar Therapeutics

  公开号：US10865186B2

  公开（公告）日：2020-12-15

  Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.

  本文提供的化合物包括式 I 的化合物及其药学上可接受的盐和溶剂。本文所述化合物与药物发现、药物治疗、生理学、有机化学和聚合物化学等领域有关和/或具有应用价值。
• Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase
  作者：Joby Eldo、Sabrina Heng、Evan R. Kantrowitz

  DOI：10.1016/j.bmcl.2006.12.050

  日期：2007.4

  A series of inhibitors of the aspartate transcarbamoylase, an enzyme involved in pyrimidine nucleotide biosynthesis, has been synthesized. These inhibitors are analogues of a highly potent inhibitor of this enzyme, N-phosphonacetyl-L-aspartate (PALA). Analogues have been synthesized with modifications at the alpha- and beta-carboxylates as well as at the aspartate moiety. The ability of these compounds to inhibit the enzyme was evaluated. These studies, with functional group modified PALA derivatives, showed that amide groups can be a useful substitute of the carboxylate in order to reduce the charge on the molecule, and indicate that the relative position of the functional group in the beta-position is more critical than the nature of the functional group. Some of the molecules synthesized here are potent inhibitors of the enzyme. (c) 2007 Elsevier Ltd. All rights reserved.