bis(heptyloxy)methane | 76343-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis(heptyloxy)methane
• 英文别名: diheptyloxymethane；8,10-dioxaheptadecane；formaldehyde diheptylacetal；Bis-heptyloxy-methan；1-[(Heptyloxy)methoxy]heptane；1-(heptoxymethoxy)heptane
• CAS: 76343-07-2
• 化学式: C₁₅H₃₂O₂
• 分子量: 244.418
• InChiKey: NOYRDVJSMQOXAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  287.4±8.0 °C(Predicted)
• 密度：
  0.846±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-chloromethoxy-heptane 在 碲化氢 、 水 、 一水合肼 、 potassium hydroxide 作用下， 反应 2.0h， 生成 bis(heptyloxy)methane
  参考文献：
  名称：

  Reactions of chloromethyl heptyl ether with selenium and tellurium in the system hydrazine hydrate-potassium hydroxide

  摘要：

  Chloromethyl heptyl ether reacts with selenium in the system hydrazine hydrate-potassium hydroxide with formation of a mixture of bis(heptyloxymethyl)selane (32%) and bis(heptyloxymethyl)diselane (64%). Reductive cleavage of the latter with hydrazine hydrate-KOH and subsequent alkylation with methyl iodide gave methyl(heptyloxymethyl) selane in 94% yield. Analogous reaction of tellurium with hydrazine hydrate-KOH leads to the formation of extremely unstable bis(heptyloxymethyl) ditellane and bis(heptyloxymethyl) tellane at a ratio of 1 : 4.

  DOI：

  10.1134/s1070428011120049

文献信息

• Dimethyl sulfoxide as a “methylene” source: Ru(<scp>ii</scp>) photo-catalysed facile synthesis of acetals from alcohols
  作者：Ranadeep Talukdar

  DOI：10.1039/c9nj03422f

  日期：——

  Acetals are important molecules with versatile reactivity and uses. For the first time a simple photo-catalysed facile synthesis of formaldehyde acetals is documented herein upon the reaction of alcohols with dimethyl sulfoxide under very mild conditions in the presence of air. The reactions require only 1 mol% of RuII(bpy)3Cl2 photocatalyst under blue LED irradiation (λ = 445 nm) to give good to excellent

  缩醛是具有通用反应性和用途的重要分子。本文首次报道了醇与二甲基亚砜在非常温和的条件下在空气存在下反应后，甲醛缩醛的简单光催化简便合成。在蓝色LED辐射（λ = 445 nm）下，该反应仅需要1 mol％的Ru II（bpy）3 Cl 2光催化剂，以得到相应的乙缩醛产物良好的优异产率。此处，DMSO充当“亚甲基”来源。
• PROCESS FOR PREPARING AN ALKOXYMETHYL ALKYNYL ETHER COMPOUND HAVING A TERMINAL TRIPLE BOND
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20210198172A1

  公开（公告）日：2021-07-01

  The present invention provides a process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond of the following formula (4): H—C≡C(CH 2 ) a OCH 2 OCH 2 R (4), wherein R represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, and “a” represents an integer of 1 to 10, the method comprising subjecting an alkynol compound having a terminal triple bond of the following formula (1): H—C≡C(CH 2 ) a OH (1), wherein “a” is as defined above, to an alkoxymethylation with a halomethyl alkyl ether compound of the following formula (3): RCH 2 OCH 2 X (3), wherein X represents a halogen atom, and R is as defined above, in the presence of a dialkylaniline compound of the following formula (2): [CH 3 (CH 2 ) b ][CH 3 (CH 2 ) c ]NC 6 H 5 (2), wherein b and c represent, independently of each other, an integer of 0 to 9, to form the alkoxymethyl alkynyl ether compound (4) having a terminal triple bond.

  本发明提供了一种制备具有以下式(4)的末端三键的烷氧甲基炔基醚化合物的方法：H—C≡C(CH2)aOCH2OCH2R (4)，其中R代表氢原子、具有1至9个碳原子的n-烷基基团或苯基，而“a”代表1至10的整数，所述方法包括将具有以下式(1)末端三键的炔醇化合物进行烷氧甲基化，其中H—C≡C(CH2)aOH (1)，其中“a”如上所定义，与具有以下式(3)的卤甲基烷醚化合物进行反应：RCH2OCH2X (3)，其中X代表卤素原子，R如上所定义，在存在以下式(2)的二烷基苯胺化合物的情况下进行，[CH3(CH2)b][CH3(CH2)c]NC6H5(2)，其中b和c独立地代表0至9的整数，以形成具有末端三键的烷氧甲基炔基醚化合物(4)。
• Synthesis of Formaldehyde Acetals by Phase Transfer Catalysis
  作者：Maw-Ling Wang、Shahng-Wern Chang

  DOI：10.1246/bcsj.66.2149

  日期：1993.8

  By employing phase transfer catalysis, formaldehyde acetals were synthesized from the reaction of alcohols and dibromomethane at moderate temperatures. Using a high alkaline concentration, the reac...

  通过使用相转移催化，由醇和二溴甲烷在中等温度下反应合成甲醛缩醛。使用高碱浓度，反应...
• Process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US11384041B2

  公开（公告）日：2022-07-12

  The present invention provides a process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond of the following formula (4): H—C≡C(CH2)aOCH2OCH2R (4), wherein R represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, and “a” represents an integer of 1 to 10, the method comprising subjecting an alkynol compound having a terminal triple bond of the following formula (1): H—C≡C(CH2)aOH (1), wherein “a” is as defined above, to an alkoxymethylation with a halomethyl alkyl ether compound of the following formula (3): RCH2OCH2X (3), wherein X represents a halogen atom, and R is as defined above, in the presence of a dialkylaniline compound of the following formula (2): [CH3(CH2)b][CH3(CH2)c]NC6H5 (2), wherein b and c represent, independently of each other, an integer of 0 to 9, to form the alkoxymethyl alkynyl ether compound (4) having a terminal triple bond.

  本发明提供了一种制备具有下式(4)末端三键的烷氧基甲基炔基醚化合物的工艺：H-C≡C(CH2)aOCH2OCH2R(4)，其中 R 代表氢原子、具有 1 至 9 个碳原子的正烷基或苯基，且 "a "代表 1 至 10 的整数，该方法包括使具有下式(1)的末端三键的炔醇化合物：H-C≡C(CH2)aOH(1)，其中 "a "如上定义，用下式(3)的卤代甲基烷基醚化合物进行烷氧基甲基化：RCH2OCH2X(3)，其中 X 代表卤素原子，R 如上定义，在下式(2)的二烷基苯胺化合物存在下进行烷氧基甲基化：[CH3(CH2)b][CH3(CH2)c]NC6H5(2)，其中 b 和 c 各自代表 0 至 9 的整数，形成具有末端三键的烷氧基甲基炔基醚化合物 (4)。
• Pernak; Skrzypczak; Michalak, Pharmazie, 1988, vol. 43, # 9, p. 654 - 655
  作者：Pernak、Skrzypczak、Michalak、Krysinski

  DOI：——

  日期：——