(R)-2-溴丙酸叔丁酯 | 54631-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (R)-2-溴丙酸叔丁酯
• 英文名称: (R)-tert-butyl 2-bromopropanoate
• 英文别名: (R)-(+)-2-bromo-propionic acid tert-butyl ester；tert-Butyl (2R)-2-bromopropanoate
• CAS: 54631-38-8
• 化学式: C₇H₁₃BrO₂
• 分子量: 209.083
• InChiKey: CVAWKJKISIPBOD-RXMQYKEDSA-N

物化性质

• 沸点：
  170.2±8.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-2-溴丙酸叔丁酯 在 一水合肼 作用下， 生成 L-α-Hydrazinopionsaeure-t-butylester
  参考文献：
  名称：

  Niedrich,H.; Koeller,G., Journal fur praktische Chemie (Leipzig 1954), 1974, vol. 316, p. 729 - 740

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴丙酸叔丁酯 、 (S)-N,N'-bis(p-methoxybenzyl)-3-isopropylpiperazine-2,5-dione 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 以83%的产率得到
  参考文献：
  名称：

  Enantiodiscrimination of racemic electrophiles by diketopiperazine enolates: asymmetric synthesis of methyl 2-amino-3-aryl-butanoates and 3-methyl-aspartates

  摘要：

  Enolates of (S)-N,N'-bis-(p-methoxybenzyl)-3-iso-propylpiperazine-2,5-dione exhibit high levels of enantiodiscrimination in alkylations with (RS)-1-aryl-1-bromoethanes and (RS)-2-bromoesters, affording substituted diketopiperazines containing two new stereogenic centres in high de. Deprotection and hydrolysis of the resultant substituted diketopiperazines provides a route to the asymmetric synthesis of homochiral methyl 2-amino-3-aryl-butanoates and 3-methyl-aspartates in high de and ee. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.05.033

文献信息

• [EN] PYRROLOPYRIMIDINE AMINES AS COMPLEMENT INHIBITORS<br/>[FR] PYRROLOPYRIMIDINE AMINES EN TANT QU'INHIBITEURS DU COMPLÉMENT
  申请人：BIOCRYST PHARM INC

  公开号：WO2021202977A1

  公开（公告）日：2021-10-07

  Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.

  本文披露了式（I）的化合物及其药用盐，这些化合物是裂解系统的抑制剂。还提供了包含这种化合物的药物组合物，以及使用这些化合物和组合物治疗或预防由异常裂解系统活动特征的疾病或状况的方法。
• Substituted tetrahydroisoquinolines as C5a receptor modulators
  申请人：——

  公开号：US20040006069A1

  公开（公告）日：2004-01-08

  1 Substituted tetrahydroisoquinolines and related compounds are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了替代四氢异喹啉和相关化合物。这些化合物是配体，可用于调节体内或体外的C5a受体活性，并且在治疗与人类、驯化伴侣动物和家畜动物中的病理性C5a受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的药物组成物和使用它们的方法，以及用于受体定位研究的配体使用方法。
• 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
  申请人：Ciba-Geigy Corporation

  公开号：US04410520A1

  公开（公告）日：1983-10-18

  Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin -2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

  各种取代的1-羧甲基-3-(羧甲基氨基)-2,3,4,5-四氢-1H-[1]苯并咪唑-2-酮及其功能衍生物是血管紧张素转化酶抑制剂，可用作降压剂。本发明涉及这些化合物的合成、组成以及治疗方法。
• 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
  申请人：Ciba-Geigy Corporation

  公开号：US04473575A1

  公开（公告）日：1984-09-25

  Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin -2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

  不同取代的1-羧甲基-3-(羧甲基氨基)-2,3,4,5-四氢-1H-[1]苯并嗪-2-酮及其官能衍生物是肾素-血管紧张素转换酶抑制剂，可用作降压剂。本发明涉及该类化合物的合成、组合物和治疗方法。
• Polyamide based nucleic acid analogs — synthesis of δ-amino acids with nucleic acid bases bearing side chains
  作者：Karl-Heinz Altmann、Chantal Schmit Chiesi、Carlos García-Echeverría

  DOI：10.1016/s0960-894x(97)00172-8

  日期：1997.5

  Nucleoamino acids of type I - III have been synthesized, which can serve as building blocks for novel polyamide based nucleic acid analogs. Key steps in the syntheses are the alkylation of serinol I and homoserinol 18 with tert-butyl bromoacetate or tert-butyl bromopropionate under phase transfer conditions and the introduction of thymine or uracil into the amino acid side chains by way of a Mitsunobu reaction. Cytosine derivatives were prepared through uracil --> cytosine base conversion at the stage of N-delta-BOC protected amino acid tert-butyl esters. (C) 1997 Elsevier Science Ltd.