acetate de methyl-3 adamantyl-1 | 17768-37-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetate de methyl-3 adamantyl-1
• 英文别名: 1-methyl-3-acetoxyadamantane；3-methyl-1-adamantyl acetate；3-Methyl-adamantyl-(1)-acetat；(3-methyl-1-adamantyl) acetate
• CAS: 17768-37-5
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: QNKMKDKGHALJFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetate de methyl-3 adamantyl-1 在 sodium hydroxide 、 硫酸 、 三氟化硼 、 溴 作用下， 反应 16.0h， 生成 (3-hydroxy-5-methyladamantan-1-yl)acetic acid
  参考文献：
  名称：

  Bott,K., Chemische Berichte, 1968, vol. 101, p. 564 - 573

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-1-金刚烷醇 在 硫酸 、 乙酸酐 作用下， 以 正己烷 、 正庚烷 、 环己烷 、 乙酸乙酯 为溶剂， 生成 acetate de methyl-3 adamantyl-1
  参考文献：
  名称：

  Apoptosis inducing adamantyl derivatives and their usage as anti-cancer

  摘要：

  本发明涉及含有特定金刚烷基或金刚烷基衍生物的视黄醇类化合物，可诱导癌细胞凋亡。这些金刚烷基视黄醇衍生物对许多癌症和实体瘤的治疗有用，特别是雄激素非依赖性前列腺癌、皮肤癌、胰腺癌、结肠癌、黑色素瘤、卵巢癌、肝癌、小细胞肺癌、非小细胞肺癌、宫颈癌、脑癌、膀胱癌、乳腺癌、神经母细胞瘤/胶质母细胞瘤和白血病。此外，本发明还涉及新型金刚烷基或金刚烷基衍生物化合物，其用作治疗或预防角化病和其他皮肤病以及其他疾病的活性剂。

  公开号：

  US06127415A1

文献信息

• Fluorine-Containing Sulfonic Acid Salt, Fluorine-Containing Sulfonic Acid Salt Resin, Resist Composition, and Pattern Forming Method Using Same
  申请人：Central Glass Company, Limited

  公开号：US20150198879A1

  公开（公告）日：2015-07-16

  Disclosed is a fluorine-containing sulfonic acid salt resin having a repeating unit represented by the following general formula (3). In the formula, each A independently represents a hydrogen atom, a fluorine atom or a trifluoromethyl group, and n represents an integer of 1-10. W represents a bivalent linking group, R 01 represents a hydrogen atom or a monovalent organic group, and M + represents a monovalent cation. A resist composition containing this resin is further superior in sensitivity, resolution and reproducibility of mask pattern and is capable of forming a pattern with a low LER.

  本公开了一种含氟磺酸盐树脂，其具有以下通用式（3）所代表的重复单元。在该式中，每个A独立地表示氢原子、氟原子或三氟甲基基团，n表示1-10的整数。W表示二价连接基团，R01表示氢原子或一价有机基团，M+表示一价阳离子。含有该树脂的抗蚀组合物在感光性、分辨率和掩膜图案的重现性方面更加优越，并且能够形成具有较低LER的图案。
• Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
  申请人：Galderma Research & Development S.N.C.

  公开号：US06462064B1

  公开（公告）日：2002-10-08

  The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and/or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

  该发明涉及到发现含有类视黄醇相关化合物的特定金刚烷基或金刚烷基衍生物诱导癌细胞凋亡，并因此可用于治疗包括晚期癌症在内的癌症。此外，本发明涉及到新型含有类视黄醇化合物的金刚烷基或金刚烷基衍生物及其用于治疗和/或预防癌症、角化障碍、皮肤病和其他治疗方案的用途。更具体地，已经证明这种金刚烷基化合物，例如6-[3-(1-金刚烷基)-4-甲氧基苯基]-2-萘酸、2-[3-(1-金刚烷基)-4-甲氧基苯基]-5-苯并咪唑羧酸和6-[3-(1-金刚烷基)-4,5-亚甲二氧基苯基]-2-萘酸，可用于治疗或预防宫颈癌和宫颈上皮内瘤变，包括高度和低度上皮内瘤变。
• AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0661271A1

  公开（公告）日：1995-07-05

  An azepine derivative represented by general formula (1) or a nontoxic salt thereof, a process for producing the same, and a therapeutic agent containing the same as the active ingredient for treating diseases related to σ-receptor, wherein R represents a group represented by general formula (2) (wherein R¹ represents hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or optionally substituted phenyl, and n represents 0 or 1), C₅-C₈ cycloalkyl which may be substituted by lower alkyl, norbornyl, bicyclo[3.3.1]nonyl, naphthyl, 1,3-benzodioxolyl, pyridyl or thienyl; m represents an integer of 0 to 4; and C* represents an asymmetric carbon atom. The compound (1) and nontoxic salt thereof have a high affinity for σ-receptor but scarcely any affinity for other receptors, thus being utilized for treating diseases related to σ-receptor, such as schizophrenia.

  通式(1)代表的氮杂环庚烷衍生物或其无毒盐，生产该衍生物的工艺，以及含有该衍生物作为活性成分的治疗剂，用于治疗与σ-受体有关的疾病、其中 R 代表通式 (2) 所代表的基团（其中 R¹ 代表氢、低级烷基、低级烷氧基、羟基、卤素或任选取代的苯基，且 n 代表 0 或 1）、可被低级烷基取代的 C₅-C₈ 环烷基、降冰片烷基、双环[3.3.1]壬基、萘基、1,3-苯并二恶茂基、吡啶基或噻吩基；m 代表 0 至 4 的整数；C* 代表不对称碳原子。化合物(1)及其无毒盐对σ受体有很高的亲和力，但对其他受体几乎没有亲和力，因此可用于治疗与σ受体有关的疾病，如精神分裂症。
• ADAMANTANE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0757040A1

  公开（公告）日：1997-02-05

  A compound represented by general formula (1) or an innocuous salt thereof, a process for producing the same, and a schizophrenia remedy containing the same as the active ingredient (wherein the nitrogeneous ring B represents 3-azabicyclo [3.2.2] nonan-3-yl or 4-azatricyclo [4.3.1.13.8] undecan-4-yl; and R represents hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen). The above compound and salt have a high affinity for sigma-binding sites and are useful as an antischizophrenic drug.

  一种由通式（1）代表的化合物或其无毒盐，一种生产该化合物或盐的工艺，以及一种含有该化合物或盐作为有效成分的精神分裂症药物（其中硝基环 B 代表 3-氮杂双环[3.2.2]壬烷-3-基或 4-氮杂三环[4.3.1.13.8]十一烷-4-基；R 代表氢、低级烷基、低级烷氧基、羟基或卤素）。上述化合物和盐对 sigma 结合位点具有高亲和力，可用作抗精神分裂症药物。
• ADAMANTANE DERIVATIVES AND PROCESS FOR PRODUCING THEM
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP0927711A1

  公开（公告）日：1999-07-07

  In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2):    wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R1 and R2 may bond together to form a double bond or an aromatic or non-aromatic ring; Y is O or OH and n = 1 to 3; or the imide compound and a co-catalyst (e.g., a transition metal compound), an adamantane derivative having a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is oxidized with oxygen. According to the above method, an adamantane derivative having a hydroxyl group together with a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is efficiently obtained.

  在存在式（2）所示的酰亚胺化合物（如 N-羟基邻苯二甲酰亚胺）的情况下： 其中 R1 和 R2 分别代表氢原子、卤素原子、烷基、芳基、环烷基；或 R1 和 R2 可键合在一起形成双键或芳香环或非芳香环；Y 为 O 或 OH，n = 1 至 3； 或亚胺化合物和助催化剂（如过渡金属化合物），具有诸如硝基、氨基、羟基、羧基、羟甲基和异氰酸基等官能团的金刚烷衍生物与氧发生氧化反应。根据上述方法，可有效地获得具有羟基和硝基、氨基、羟基、羧基、羟甲基和异氰酸基等官能团的金刚烷衍生物。