2-fluoro-n-hexan-1-ol | 1786-48-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 2-fluoro-n-hexan-1-ol
• 英文别名: 2-fluoro-hexan-1-ol；2-Fluor-hexan-1-ol；2-Fluor-hexanol；2-Fluorohexan-1-ol
• CAS: 1786-48-7
• 化学式: C₆H₁₃FO
• 分子量: 120.167
• InChiKey: NVIVQGNQOLBSLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-fluoro-n-hexan-1-ol 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 MTPA ester of 2-fluoro-n-hexan-1-ol
  参考文献：
  名称：

  Enantioselective bioreduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae

  摘要：

  Biocatalytic reduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae underwent smoothly and yielded (S)-2-fluorinated alkanols with high enantioselectivities. The conversion rate was markedly depending on the configuration of alkene moiety of the substrate, the chain length of alkyl group at beta position of C=C bond, as well as the reaction conditions. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2011.02.011
• 作为产物：
  描述：

  丁基环氧乙烷 在 氢氟酸 作用下， 以 乙腈 为溶剂， 生成 2-fluoro-n-hexan-1-ol
  参考文献：
  名称：

  Wiechert,K.; Mohr,P., Zeitschrift fur Chemie, 1965, vol. 5, p. 380 - 381

  摘要：

  DOI：

文献信息

• ALIPHATIC VICINAL FLUOROBROMIDES SOME PREPARATIONS AND REACTIONS
  作者：F. L. M. Pattison、D. A. V. Peters、F. H. Dean

  DOI：10.1139/v65-223

  日期：1965.6.1

  The addition of "BrF", using N-bromoamides in anhydrous hydrogen fluoride, to a number of aliphatic alkenes has been studied. As expected, the bromine atom in the resultant vicinal fluorobromides exhibited relatively low reactivity in nucleophilic and hydrogenolytic reactions.

  已经研究了在无水氟化氢中使用 N-溴酰胺将“BrF”添加到许多脂肪族烯烃中。正如预期的那样，所得邻位氟溴化物中的溴原子在亲核和氢解反应中表现出相对较低的反应性。
• [EN] PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL<br/>[FR] COMPOSÉ PYRIMIDINE ET SON UTILISATION DANS LA LUTTE ANTIPARASITAIRE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2010134478A1

  公开（公告）日：2010-11-25

  A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

  以下公式（I）所代表的嘧啶化合物对害虫具有出色的控制活性，并可用作杀虫剂的活性成分。
• NOVEL COMPOUNDS AND METHODS FOR SYNTHESIS AND THERAPY
  申请人：BISCHOFBERGER NORBERT W.

  公开号：US20050176758A1

  公开（公告）日：2005-08-11

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  本发明涉及新型化合物。该化合物通常包含一个酸性基团、一个碱性基团、一个取代的氨基或N-酰基和一个具有可选羟基化的烷基部分。本发明还涉及包含所述抑制剂的制药组合物。还描述了用于抑制怀疑含有神经氨酸酶的样品中神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、标记化合物的结合物以及用于检测神经氨酸酶活性的测定方法。
• PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL
  申请人：Mizuno Hajime

  公开号：US20120041009A1

  公开（公告）日：2012-02-16

  A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

  下面公式（I）所表示的嘧啶化合物具有优异的害虫控制活性，并且可用作害虫控制剂的活性成分。
• DIACETYLENE DERIVATIVE AND LIQUID CRYSTALLINE POLYMER HAVING DIACETYLENE STRUCTURE
  申请人：Arajawa Yuki

  公开号：US20130324684A1

  公开（公告）日：2013-12-05

  The present invention provides a diacetylene derivative represented by the following formula (A) which exhibits liquid crystallinity by itself and has a large refractive index anisotropy or does not exhibit liquid crystallinity by itself but exhibits a large refractive index anisotropy when added to a liquid crystalline compound: R1-Sp1-(Ar1) p -(Ar3) q -(Phe) r -C≡C—C≡C-(Phe) r -(Ar4) q -(Ar2) p -Sp2-R2  (A) (wherein R1 and R2 are a hydrogen, halogen, cyano, isothiocyanate, alkyl, alkenyl, alkynyl or reactive group, SP1 and SP2 are each a spacer group, Ar1 and Ar2 are each a non-substituted or substituted aromatic carbocyclic or heterocyclic group, Ar3 and Ar4 are each a non-substituted or substituted heterocyclic group, Phe is a non-substituted or substituted 1,4-phenylene group, and p, q and r are each 0 or 1.

  本发明提供了一种二乙炔衍生物，其由以下式(A)所表示，它本身表现出液晶性并具有大的折射率各向异性，或者虽然本身不具有液晶性，但当添加到液晶化合物中时表现出大的折射率各向异性：R1-Sp1-(Ar1)p-(Ar3)q-(Phe)r-C≡C—C≡C-(Phe)r-(Ar4)q-(Ar2)p-Sp2-R2  (A)（其中，R1和R2分别是氢、卤素、氰、异硫氰酸酯、烷基、烯基、炔基或反应基，SP1和SP2分别是间隔基，Ar1和Ar2分别是非取代或取代的芳香环烷基或杂环烷基，Ar3和Ar4分别是非取代或取代的杂环基，Phe是非取代或取代的1,4-苯基基团，p、q和r分别为0或1。）