(2-bromophenyl)(3-bromothiophen-2-yl)methanone | 31479-31-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-bromophenyl)(3-bromothiophen-2-yl)methanone
• 英文别名: o-Bromphenyl-3-brom-2-thienylketon；(2-bromophenyl)-(3-bromothiophen-2-yl)methanone
• CAS: 31479-31-9
• 化学式: C₁₁H₆Br₂OS
• 分子量: 346.042
• InChiKey: FXDROZUNXBSHPR-UHFFFAOYSA-N

物化性质

• 沸点：
  402.8±30.0 °C(Predicted)
• 密度：
  1.827±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-bromophenyl)(3-bromothiophen-2-yl)methanone 生成 8H-indeno[2,1-b]thiophen-8-one
  参考文献：
  名称：

  YORK, BILLIE M. (JR)

  摘要：

  DOI：
• 作为产物：
  描述：

  3-溴噻吩 、 2-溴苯甲酰氯 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 5.25h， 以75%的产率得到(2-bromophenyl)(3-bromothiophen-2-yl)methanone
  参考文献：
  名称：

  酰化/二重 Buchwald-Hartwig 反应区域选择性合成噻吩并[3,2-b]喹诺酮类药物

  摘要：

  A variety of thienoquinolones were synthesized from readily accessible thiophene derivatives by regioselective acylations and subsequent two‐fold Buchwald–Hartwig–amination. This cyclization allows a convenient synthesis of biologically and pharmaceutically important thienoquinolones. Several thienoquinolones were synthesized in good to very good yields. The optical properties of the products were studied in detail.

  DOI：

  10.1002/ejoc.201901247

文献信息

• Regioselective Synthesis of Thieno[3,2-<i>b</i> ]quinolones by Acylation/Two-Fold Buchwald-Hartwig Reactions
  作者：Julia Janke、Peter Ehlers、Alexander Villinger、Peter Langer

  DOI：10.1002/ejoc.201901247

  日期：2019.11.24

  A variety of thienoquinolones were synthesized from readily accessible thiophene derivatives by regioselective acylations and subsequent two‐fold Buchwald–Hartwig–amination. This cyclization allows a convenient synthesis of biologically and pharmaceutically important thienoquinolones. Several thienoquinolones were synthesized in good to very good yields. The optical properties of the products were studied in detail.
• YORK, BILLIE M. (JR)
  作者：YORK, BILLIE M. (JR)

  DOI：——

  日期：——