3,3-Dimethyl-1-oxaspiro<3.5>nonan-2-one | 22741-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3,3-Dimethyl-1-oxaspiro<3.5>nonan-2-one
• 英文别名: 3,3-dimethyloxetan-2-one-4-spirocyclohexane；3,3-dimethyloxetan-2-on-4-spirocyclohexane；3,3-dimethyl-1-oxaspiro[3.5]nonan-2-one；3,3-dimethyl-1-oxa-spiro[3.5]nonan-2-one
• CAS: 22741-15-7
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: KFHKVNGUXWIEKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  3,3-Dimethyl-1-oxaspiro<3.5>nonan-2-one 生成 异亚丙基环己烷
  参考文献：
  名称：

  Stereospecific introduction of double bounds via thermolysis of .beta.-lactones

  摘要：

  DOI：

  10.1021/ja00761a036
• 作为产物：
  描述：

  2-(1-Hydroxycyclohexyl)-2-methylpropanoic acid 在 吡啶 、 苯磺酰氯 作用下， 以94%的产率得到3,3-Dimethyl-1-oxaspiro<3.5>nonan-2-one
  参考文献：
  名称：

  通过E 1型电离/消除β-内酯合成环状和无环βγ-不饱和car☐水杨酸

  摘要：

  DOI：

  10.1016/s0040-4020(01)82011-1

文献信息

• Pt-Catalyzed Rearrangement of Oxaspirohexanes to 3-Methylenetetrahydrofurans: Scope and Mechanism
  作者：Christian A. Malapit、Sampada M. Chitale、Meena S. Thakur、Rosa Taboada、Amy R. Howell

  DOI：10.1021/acs.joc.5b00604

  日期：2015.5.15

  A novel Pt-catalyzed rearrangement of oxaspirohexanes to 3-methylenetetrahydrofurans is reported. Mechanistic studies by 13C-labeling experiments confirm oxidative addition of Pt(II) regioselectively to the least substituted carbon–carbon bond of the cyclopropane to form a platinacyclobutane intermediate. To our knowledge, this is the first alkoxy-substituted platinacyclobutane that has been observed

  报道了新的Pt催化的氧杂螺正己烷重排成3-亚甲基四氢呋喃。通过13 C标记实验进行的机理研究证实，Pt（II）区域选择性地氧化添加到环丙烷的最少取代的碳-碳键上，从而形成铂环丁烷中间体。据我们所知，这是第一个在光谱上观察到的烷氧基取代的铂基环丁烷。描述了这种新的Pt催化转化的范围和提出的机理。
• Synthesis of .alpha.,.alpha.,.beta.,.beta.-Tetrasubstituted .beta.-Lactones from Ketones, Ethyl .alpha.-Bromoisobutyrate, and Indium or Zinc. Factors Influencing the .beta.-Lactone Formation in the Electrochemical and the Classical Procedure of the Reformatsky Reaction
  作者：Hans Schick、Ralf Ludwig、Karl-Heinz Schwarz、Katharina Kleiner、Annamarie Kunath

  DOI：10.1021/jo00090a038

  日期：1994.6

  An efficient synthesis of alpha,alpha,beta,beta-tetrasubstituted beta-lactones is achieved by an electrochemically supported Reformatsky reaction of aliphatic and aromatic ketones with ethyl alpha-bromoisobutyrate at a sacrificial indium anode. Under these conditions, in most cases the expected beta-hydroxy esters are formed only in negligible amounts or not at all. beta-Lactones are also obtained with a sacrificial zinc anode or even with indium or zinc powder. The substitution pattern of the reactants, the polarity of the solvent, and the applied metal are recognized as factors influencing the extent of the beta-lactone formation.
• Synthesis of .beta.-Lactones via a Spontaneous Intramolecular Cyclization of O-Lithiated Phenyl .beta.-Hydroxyalkanoates Obtained by Aldolization of Ketones or Aldehydes with Lithium Enolates of Phenyl Esters
  作者：Christine Wedler、Annamarie Kunath、Hans Schick

  DOI：10.1021/jo00108a052

  日期：1995.2
• Schick, Hans; Ludwig, Ralf; Schwarz, Karl-Heinz, Angewandte Chemie, 1993, vol. 105, # 8, p. 1218 - 1220
  作者：Schick, Hans、Ludwig, Ralf、Schwarz, Karl-Heinz、Kleiner, Katharina、Kunath, Annamarie

  DOI：——

  日期：——
• A practical and efficient method for the synthesis of .beta.-lactones
  作者：Rick L. Danheiser、James S. Nowick

  DOI：10.1021/jo00003a047

  日期：1991.2

  This paper describes a convenient one-step preparation of beta-lactones based on the addition of thiol ester enolates to carbonyl compounds. Under the proper conditions the resulting aldolates undergo spontaneous cyclization to produce beta-lactones in good to excellent yield. The new beta-lactone synthesis provides access to 2-oxetanones with a variety of substituents and substitution patterns. In general, thiol ester enolates combine with carbonyl compounds to form the less sterically crowded beta-lactone diastereomers, and in some cases the reaction proceeds with excellent stereoselectivity. In conjunction with the stereospecific decarboxylation of beta-lactones, this chemistry also provides a very attractive approach to the synthesis of substituted alkenes.