N-[(E)-4-[tert-butyl(diphenyl)silyl]oxy-1-tributylstannylbut-1-enyl]-N,4-dimethylbenzenesulfonamide | 1486515-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(E)-4-[tert-butyl(diphenyl)silyl]oxy-1-tributylstannylbut-1-enyl]-N,4-dimethylbenzenesulfonamide
• CAS: 1486515-52-9
• 化学式: C₄₀H₆₁NO₃SSiSn
• 分子量: 782.791
• InChiKey: XAQDUOMLSYBJNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.85
• 重原子数：
  47
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[(E)-4-[tert-butyl(diphenyl)silyl]oxy-1-tributylstannylbut-1-enyl]-N,4-dimethylbenzenesulfonamide 在 4-二甲氨基吡啶 、 tris-(dibenzylideneacetone)dipalladium(0) 、 三苯胂 、 碘 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 19.0h， 生成 methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate
  参考文献：
  名称：

  Syntheses of α-Stannylated and α-Iodinated Enamides via Molybdenum-Catalyzed Hydrostannation

  摘要：

  alpha-Stannylated and alpha-iodinated enamides can easily be obtained by molybdenum-catalyzed regio- and stereoselective hydrostannation and subsequent tin-iodine exchange. These functionalized enamides are interesting building blocks for a wide range of cross-coupling reactions giving access to various types of alpha-substituted enamides.

  DOI：

  10.1021/ol4031028
• 作为产物：
  描述：

  N-甲基对甲苯磺酰胺 在 1,10-菲罗啉 、 fac-molybdenum tricarbonyl (tert-butyl isocyanide)3 、 一氧化碳 、 potassium carbonate 、 copper(II) sulfate 、 对苯二酚 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 生成 N-[(E)-4-[tert-butyl(diphenyl)silyl]oxy-1-tributylstannylbut-1-enyl]-N,4-dimethylbenzenesulfonamide
  参考文献：
  名称：

  Syntheses of α-Stannylated and α-Iodinated Enamides via Molybdenum-Catalyzed Hydrostannation

  摘要：

  alpha-Stannylated and alpha-iodinated enamides can easily be obtained by molybdenum-catalyzed regio- and stereoselective hydrostannation and subsequent tin-iodine exchange. These functionalized enamides are interesting building blocks for a wide range of cross-coupling reactions giving access to various types of alpha-substituted enamides.

  DOI：

  10.1021/ol4031028

文献信息

• Syntheses of α-Stannylated and α-Iodinated Enamides via Molybdenum-Catalyzed Hydrostannation
  作者：Pulakesh Maity、Manuel R. Klos、Uli Kazmaier

  DOI：10.1021/ol4031028

  日期：2013.12.20

  alpha-Stannylated and alpha-iodinated enamides can easily be obtained by molybdenum-catalyzed regio- and stereoselective hydrostannation and subsequent tin-iodine exchange. These functionalized enamides are interesting building blocks for a wide range of cross-coupling reactions giving access to various types of alpha-substituted enamides.