N-(11-溴十一基)氨基甲酸叔丁酯 | 463930-53-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(11-溴十一基)氨基甲酸叔丁酯
• 中文别名: N-(11-溴十一烷基)氨基甲酸叔丁酯
• 英文名称: tert-butyl (11-bromoundecyl)carbamate
• 英文别名: N-(11-Bromoundecyl)carbamic acid tert-butyl ester；tert-butyl N-(11-bromoundecyl)carbamate
• CAS: 463930-53-2
• 化学式: C₁₆H₃₂BrNO₂
• 分子量: 350.34
• InChiKey: DUEMGHARGAXFIJ-UHFFFAOYSA-N

物化性质

• 熔点：
  60-62℃
• 密度：
  1.101

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  N-(11-溴十一基)氨基甲酸叔丁酯 在 4-二甲氨基吡啶 、 三乙胺 、 肼 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 28.0h， 生成 tert-butyl 11-mercaptoundecylcarbamate
  参考文献：
  名称：

  Immobilization of Rhodium Complexes at Thiolate Monolayers on Gold Surfaces:  Catalytic and Structural Studies

  摘要：

  Chiral rhodium-diphosphine complexes have been incorporated into self-assembled thiolate monolayers (SAMS) on gold colloids. Catalysts of this type are of interest because they combine properties of homogeneous and heterogeneous systems. In addition, it should be possible to influence the catalytic properties of the metal center by the neighboring thiolate molecules. Colloids with a diameter of ca. 3 nm, coated with a mixed monolayer of n-octanethiolates and thiolates with chiral rhodium-PYRPHOS end groups, were studied as hydrogenation catalysts. With methyl a-acetamido-cinnamate as substrate, virtually the same enantioselectivities (up to 93% ee) and full conversion were obtained as with the corresponding homogeneous [Rh(COD)(PYRPHOS)]BArF catalyst. The colloids were easily recovered by filtration and reused as catalysts three times without loss of enantioselectivity. STM studies of analogous SAMS on Au(111) gave a detailed picture of the structure and dynamics of mixed monolayers of this type. The STM images showed that the catalyst-bearing thiolates are distributed statistically on the surface and that the ordered structure of the n-octanethiolate SAM can be retained during incorporation of the catalyst-bearing thiols using the place-exchange methodology.

  DOI：

  10.1021/ja0500714
• 作为产物：
  描述：

  11-aminoundecan-1-ol 在 氢溴酸 、 三乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 38.0h， 生成 N-(11-溴十一基)氨基甲酸叔丁酯
  参考文献：
  名称：

  Self‐Assembly of Discrete Oligomers of Naphthalenediimides in Bulk and on Surfaces

  摘要：

  摘要我们在此报告了烷基桥接萘二亚胺（NDI）离散低聚物的合成，并研究了它们在块体、溶液和液固界面上的分子纳米结构。通过迭代合成方法，多个 NDI 核心在其酰亚胺端与短饱和烷基二胺（C3 和 C12）或长不饱和烷基二胺（u2C33 至 u8C100）桥接。通过探测 NDI 核心在溶液中的光物理特性，可以观察到它们之间强烈的分子间相互作用。在大体积中，无论采用饱和还是不饱和间隔物，离散的 NDI 低聚物都优先以片状形态有序排列。此外，分子结构和结晶条件在纳米级有序化中都起着重要作用。长的不饱和烷基链更倾向于折叠链构象，而饱和烷基链类似物则形成拉伸排列。在溶液-固体界面上，观察到清晰的层状区域。这些结果表明，要获得离散低聚物的明确结构，仅有精确的化学结构是不够的，还必须结合精确的加工条件。

  DOI：

  10.1002/chem.202303107

文献信息

• Heterocyclic Bis-Cations as Starting Hits for Design of Inhibitors of the Bifunctional Enzyme Histidine-Containing Protein Kinase/Phosphatase from <i>Bacillus</i> <i>s</i><i>ubtilis</i>
  作者：Helena Ramström、Maryline Bourotte、Claude Philippe、Martine Schmitt、Jacques Haiech、Jean-Jacques Bourguignon

  DOI：10.1021/jm021043o

  日期：2004.4.1

  phosphorylation of HPr (histidine-containing protein) at Ser-46 by the ATP-dependent HPr kinase, which in Bacillus subtilis, Lactobacillus casei, and Staphylococcus xylosus also exhibits phosphatase activity and is thus a bifunctional enzyme (HPrK/P). Since deficiency of HPrK/P in S. xylosus, L. casei, and B. subtilis mutants leads to severe growth defects, inhibitors of the enzyme could form a new family of antibiotic

  在低鸟嘌呤和低胞嘧啶革兰氏阳性细菌中碳分解代谢物阻遏/激活的主要机制似乎涉及到ATP依赖性HPr激酶在Ser-46处HPr（含组氨酸的蛋白）的磷酸化，该酶在枯草芽孢杆菌中，干酪乳杆菌和木糖葡萄球菌也具有磷酸酶活性，因此是一种双功能酶（HPrK / P）。由于木糖链球菌，干酪乳杆菌和枯草芽孢杆菌突变体中HPrK / P的缺乏会导致严重的生长缺陷，因此该酶的抑制剂可能会形成一个新的抗生素药物家族。这项研究的目的是筛选一个内部化学文库，以鉴定作为枯草芽孢杆菌中HPrK / P抑制剂的命中物，并使用放射性体外测定法从命中优化中进一步提取结构特征的其他信息。对称的双阳离子化合物LPS 02-10-L-D09（2a）具有桥接两个2-氨基苯并咪唑部分的12个碳原子的烷基连接基，被确定为具有10 microM的EC（50）值的非ATP模拟化合物在以HPr为底物的激酶测定中 该物质还抑制了添加无机磷酸盐后触发的HPrK
• Synthesis of Bifunctional Hydroxamic Acids as Novel Ligands for the Hydrophilic Stabilization of Iron Oxide Nanoparticles
  作者：Andreas Hofmann、Christina Graf、Shih-Hao Kung、Myeongseob Kim、Xiaogang Peng、Randa El-Aama、Eckart Rühl

  DOI：10.1055/s-0029-1218654

  日期：2010.4

  synthesizing bifunctional hydroxamic acids containing carboxylic acid or amino functionalities is reported. Various products from simple alkyl to complex dendrimer-like structures are described. Such molecules have recently been used in ligand-exchange reactions for the hydrophilic stabilization of originally oleic acid protected iron oxide nanoparticles. protecting groups - hydroxamic acids - hydrogenation

  报道了合成包含羧酸或氨基官能团的双官能异羟肟酸的一般方法。描述了从简单烷基到复杂树状大分子结构的各种产物。此类分子最近已用于配体交换反应中，以对最初由油酸保护的氧化铁纳米粒子进行亲水性稳定作用。 保护基-异羟肟酸-氢化-醚-烷基化
• Alkylamine derivates as anti-fouling agents
  申请人：Bayer Aktiengesellschaft

  公开号：EP1245558A1

  公开（公告）日：2002-10-02

  The invention relates to new and known compounds as well as methods for preventing the attachment of aquatic organisms to surfaces which are submerged for extensive periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with new alkylamine derivatives as antifouling agents. The invention is beneficiary for the environment in that it will permit the use of copper- and tin-free paints.

  这项发明涉及新的和已知的化合物，以及防止水生生物附着在长时间浸泡在水中的表面上的方法。更具体地说，这项发明涉及使用新的烷胺衍生物作为防污剂来保护浸入表面。该发明对环境有益，因为它将允许使用不含铜和锡的涂料。
• Alkylamine derivatives as antifouling agents
  申请人：——

  公开号：US20040118318A1

  公开（公告）日：2004-06-24

  The invention relates to methods for preventing the attachment of aquatic organisms to surfaces that are submerged for extensive periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with alkylamine derivatives as antifouling agents. The invention is beneficiary for the environment in that it will permit the use of copper- and tin-free paints.

  本发明涉及一种防止水生生物附着在长时间浸泡在水中的表面上的方法。更具体地说，本发明涉及使用烷基胺衍生物作为防污剂来保护浸没表面。该发明有益于环境，因为它将允许使用无铜和无锡的涂料。
• Inkless Microcontact Printing on Self-Assembled Monolayers of Fmoc-Protected Aminothiols
  作者：Alexander A. Shestopalov、Robert L. Clark、Eric J. Toone

  DOI：10.1021/ja076226k

  日期：2007.11.1

  Here we describe a new microcontact printing technique (mu CP), based on a catalytic reaction between an Fmoc-protected self-assembled monolayer (SAM) of aminothiols chemisorbed on a gold surface and an elastomeric stamp bearing covalently attached piperidine. The elastomeric stamp was used to selectively cleave Fmoc groups from the surface of a SAM on gold in the places of conformal contact. The technique permits nanoscale pattern fabrication with edge resolution less than 50 nm, avoiding problems of conventional microcontact printing associated with diffusion of chemical "ink", and provides a simple method for the chemical modification of SAMs.