6-羟基色满-2-酮 | 2669-94-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 3,4-二氢香豆素
• 中文名称: 6-羟基色满-2-酮
• 英文名称: 6-hydroxy-3,4-dihydrocoumarin
• 英文别名: 6-hydroxy-3,4-dihydrochromen-2-one；6-hydroxychroman-2-one；6-hydroxychromanone；6-hydroxy-chroman-2-one；6-Hydroxy-chroman-2-on；3,4-dihydro-6-hydroxy-2H-1-benzopyran-2-one
• CAS: 2669-94-5
• 化学式: C₉H₈O₃
• 分子量: 164.161
• InChiKey: ZCNZNVIRVHJXKV-UHFFFAOYSA-N

物化性质

• 熔点：
  162-163 °C
• 沸点：
  132-157 °C(Press: 5-6 Torr)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-羟基色满-2-酮 在 三氯化铝 、 sodium chloride 作用下， 生成 4,7-dihydroxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  315.围-羟基羰基化合物。第一部分。邻羟基-茚满酮，-四氢萘酮和-苯并环庚烯酮的合成

  摘要：

  DOI：

  10.1039/jr9560001585
• 作为产物：
  描述：

  反式-2-羟基肉桂酸 在 sodium amalgam 、 potassium peroxomonosulphate 作用下， 生成 6-羟基色满-2-酮
  参考文献：
  名称：

  Neubauer; Flatow, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1907, vol. 52, p. 392

  摘要：

  DOI：

文献信息

• NOVEL USE OF SUBSTITUTED CHROMAN-6-OLS
  申请人：DSM IP ASSETS B.V.

  公开号：US20210030022A1

  公开（公告）日：2021-02-04

  The present invention is directed towards the use of substituted chroman-6-ols of formula (I) wherein R 1 and R 2 are independently from each other H or C 1-11 -alkyl or (CH 2 ) n —OH with n being an integer from 1 to 4, or R 1 and R 2 represent together a keto group, 10 A is CHR 3 or C(═O), and wherein R 3 , R 4 and R 6 are independently from each other H or C 1-4 -alkyl, and wherein R 5 is H or OH or C 1-4 -alkyl or C 1-4 -alkoxy, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols of formula (I).

  本发明涉及使用式(I)的取代基氧杂环己烯-6-醇，其中R1和R2分别独立地为H或C1-11-烷基或(CH2)n—OH，其中n为1至4的整数，或者R1和R2共同表示酮基，A为CHR3或C(═O)，其中R3、R4和R6分别独立地为H或C1-4-烷基，R5为H或OH或C1-4-烷基或C1-4-烷氧基，作为抗氧化剂，特别是在饲料中，如宠物食品和饲料成分，如鱼粉、昆虫粉和禽畜粉，以及富含PUFA的油，如海洋油、微生物油、真菌油、藻类油和富含PUFA的植物油。本发明还涉及含有式(I)的这种取代基氧杂环己烯-6-醇的饲料成分和用于昆虫、水生和陆生动物的饲料。
• PREPARATION COMPRISING CHROMAN-2-ONE DERIVATIVES
  申请人：Mujica-Fernaud Teresa

  公开号：US20100291009A1

  公开（公告）日：2010-11-18

  The invention relates to preparations comprising at least one compound of the formula (I), where the substituents R 1 to R 4 have a meaning indicated in claim 1 , and salts and solvates thereof, and to the use thereof and selected compounds of the formula (I).

  该发明涉及包含至少一种式(I)化合物的制剂，其中取代基R1至R4具有权利要求1中指示的含义，以及其盐和溶剂合物，以及其用途和选择的式(I)化合物。
• Carboxylic acid leukotriene B4 antagonists
  申请人：Hoffmann-La Roche Inc.

  公开号：US05273999A1

  公开（公告）日：1993-12-28

  Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ; Y is O, --CH.sub.2 --CH.sub.2, --CH.dbd.CH--, --C.tbd.C--, or --OCH.sub.2 C.sub.6 H.sub.4 --; Z is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--; f, h, k, m and t, independently, are 0 or 1; n is an integer from 1 to 12; R.sup.1 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl, or aralkyl; and A is B or --O--B, wherein B is a mono-, di- or tricyclic aromatic or heteroaromatic moiety substituted by the group --COR.sup.2, --(O).sub.t --(W).sub.s --COR.sup.2 or --(CH.dbd.CH).sub.p COR.sup.2 and which may also contain up to 4 additional substituents selected, independently, from the group consisting of halogen, cyano, lower alkyl, lower alkoxy, sulfonamido, alkanoyl, aroyl, --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, provided that no more than one of said substituents is --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, and wherein E is COR.sup.2 or R.sup.2, W is --CR.sup.3 R.sup.4 --, Q is O or carbonyl, p is an integer from 1 to 2, s and s', independently, are an integer from 1-12, s" and s'", independently, are an integer from 0 to 12, C.sub.6 H.sub.4 is a 1,2-, 1,3-, or 1,4-phenylene moiety, and R.sup.2 is hydroxy, lower alkoxy or NR.sup.3 R.sup.4, wherein R.sup.3 and R.sup.4, each occurrence, independently, are hydrogen or lower alkyl, their geometric and optical isomers and, when R.sup.2 is hydroxy, pharmaceutically acceptable salts thereof with bases. The compounds of formula I are potent leukotriene B.sub.4 antagonists and are therefore useful in the treatment of inflammatory diseases, such as psoriasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, ischemia/reperfusion injury, and trauma induced inflammation, such as spinal cord injury.

  式##STR1##中的化合物，其中X为O或CH.sub.2；Y为O，-CH.sub.2-CH.sub.2，-CH.dbd.CH-，-C.tbd.C-或-OCH.sub.2C.sub.6H.sub.4-；Z为-CH.sub.2-CH.sub.2-，-CH.dbd.CH-或-C.tbd.C-；f，h，k，m和t，独立地，为0或1；n为1至12的整数；R.sup.1为氢，低烷基，低烯基，环烷基或芳基烷基；A为B或--O--B，其中B是被基团--COR.sup.2，-(O).sub.t-(W).sub.s-COR.sup.2或-(CH.dbd.CH).sub.pCOR.sup.2取代的单、双或三环芳香或杂芳香基，并且还可以含有最多4个额外的取代基，独立地从卤素、氰基、低烷基、低烷氧基、磺酰胺基、烷酰基、芳酰基、-(Q).sub.k-(W).sub.s'-E或-(Q).sub.k-(W).sub.s"--C.sub.6H.sub.4-(W).sub.s'"-E中选择，只要不超过一个取代基是-(Q).sub.k-(W).sub.s'-E或-(Q).sub.k-(W).sub.s"--C.sub.6H.sub.4-(W).sub.s'"-E，其中E为COR.sup.2或R.sup.2，W为-CR.sup.3R.sup.4-，Q为O或酰基，p为1至2的整数，s和s'，独立地，为1-12的整数，s"和s'"，独立地，为0至12的整数，C.sub.6H.sub.4为1,2-，1,3-或1,4-苯亚甲基，R.sup.2为羟基，低烷氧基或NR.sup.3R.sup.4，其中R.sup.3和R.sup.4，每次出现，独立地为氢或低烷基，它们的几何和光学异构体，当R.sup.2为羟基时，其与碱形成的药用盐。公式I的化合物是强效的白三烯B.sub.4拮抗剂，因此在炎症性疾病的治疗中很有用，如银屑病、炎症性肠病、哮喘、过敏、关节炎、皮炎、痛风、肺部疾病、缺血/再灌注损伤以及创伤诱导的炎症，如脊髓损伤。
• Muscarinic antagonists
  申请人：Schering Corporation

  公开号：US05935958A1

  公开（公告）日：1999-08-10

  Di-N-substituted piperazine or 1,4-di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein Q, n, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations with acetyl-cholinesterase inhibitors of compounds capable of enhancing acetylcholine release and having the above formula.

  根据以下公式I中的Di-N-取代哌嗪或1,4-二取代哌啶化合物（包括所有异构体、盐、酯和溶剂合物）##STR1## 其中Q、n、R、R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.21、R.sup.27、R.sup.28、X和Z如本文所定义的是治疗认知障碍如阿尔茨海默病的胆碱能拮抗剂。还公开了制药组合物和制备方法。还公开了与能增强乙酰胆碱释放并具有上述公式的乙酰胆碱酯酶抑制剂的化合物的协同组合。
• Characterization of PEDOT-Quinone Conducting Redox Polymers for Water Based Secondary Batteries
  作者：Mia Sterby、Rikard Emanuelsson、Xiao Huang、Adolf Gogoll、Maria Strømme、Martin Sjödin

  DOI：10.1016/j.electacta.2017.03.068

  日期：2017.5

  conducting redox polymers based on poly(3,4-ethylenedioxythiophene) (PEDOT) and a hydroquinone pendant group have been synthesized and characterized in an acidic aqueous electrolyte. The polymers were characterized with regards to kinetics, pH dependence, and mass changes during oxidation and reduction, as well as their conductance. Both polymers show redox matching, i.e. the quinone redox reaction occurs

  锂离子技术显示出巨大的希望，可以满足向可再生能源过渡和交通运输部门电气化提出的要求。然而，对于锂离子电池的担忧，包括有限的材料资源，生产过程中的高能耗以及易燃的电解质，使得有必要研究电化学能量存储的替代技术。从丰富的结构单元中获得的具有可调节特性的有机材料以及水基电解质可以提供安全，廉价和可持续的替代方案。在这项研究中，已经合成了两种基于聚（3,4-乙撑二氧噻吩）（PEDOT）和对苯二酚侧基的导电氧化还原聚合物，并在酸性水性电解质中进行了表征。表征了聚合物的动力学，pH依赖性，氧化和还原过程中的质量变化以及它们的电导率。两种聚合物均显示出氧化还原匹配，即醌氧化还原反应发生在聚合物导电的潜在区域内，并且快速氧化还原转化涉及侧基氧化还原转化过程中的质子循环。这些性能使所提出的材料有望成为水基全有机电池的电极材料。