6-羟基色满 | 5614-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 6-羟基色满
• 英文名称: chroman-6-ol
• 英文别名: 6-hydroxychroman；6-chromanol；6-hydroxychromane；3,4-dihydrobenzopyran-6-ol；3,4-dihydro-2H-chromen-6-ol
• CAS: 5614-78-8
• 化学式: C₉H₁₀O₂
• mdl: MFCD13188256
• 分子量: 150.177
• InChiKey: GZCJJOLJSBCUNR-UHFFFAOYSA-N

物化性质

• 熔点：
  99-100 °C
• 沸点：
  305.5±31.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2932999099
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  6-羟基色满 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 1-(Chroman-6-yloxy)-3-isopropylamino-propan-2-ol
  参考文献：
  名称：

  苯并吡喃衍生物的合成及其降压活性。

  摘要：

  合成了一系列包含硝氧基的二氢苯并吡喃醇胺和二氢苯并吡喃乙醇胺。对这些化合物在麻醉犬中的心血管效果进行了研究。部分化合物表现出与β-肾上腺素受体拮抗和扩血管作用相结合的降血压活性。讨论了结构与活性之间的关系。

  DOI：

  10.1248/cpb.35.632
• 作为产物：
  描述：

  4-二氮醌 在 盐酸 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 6-羟基色满
  参考文献：
  名称：

  Kirmse, Wolfgang; Lelgemann, Rudolf; Friedrich, Klaus, Chemische Berichte, 1991, vol. 124, # 8, p. 1853 - 1863

  摘要：

  DOI：

文献信息

• Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as
  申请人：Merck & Co., Inc.

  公开号：US04537903A1

  公开（公告）日：1985-08-27

  Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

  将亚苄基-2,3-二氢苯并呋喃及类似物制备自亚苄卤代物与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代反应。这些化合物被发现是有效的局部抗炎药物。
• NOVEL USE OF SUBSTITUTED CHROMAN-6-OLS
  申请人：DSM IP ASSETS B.V.

  公开号：US20210030022A1

  公开（公告）日：2021-02-04

  The present invention is directed towards the use of substituted chroman-6-ols of formula (I) wherein R 1 and R 2 are independently from each other H or C 1-11 -alkyl or (CH 2 ) n —OH with n being an integer from 1 to 4, or R 1 and R 2 represent together a keto group, 10 A is CHR 3 or C(═O), and wherein R 3 , R 4 and R 6 are independently from each other H or C 1-4 -alkyl, and wherein R 5 is H or OH or C 1-4 -alkyl or C 1-4 -alkoxy, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols of formula (I).

  本发明涉及使用式(I)的取代基氧杂环己烯-6-醇，其中R1和R2分别独立地为H或C1-11-烷基或(CH2)n—OH，其中n为1至4的整数，或者R1和R2共同表示酮基，A为CHR3或C(═O)，其中R3、R4和R6分别独立地为H或C1-4-烷基，R5为H或OH或C1-4-烷基或C1-4-烷氧基，作为抗氧化剂，特别是在饲料中，如宠物食品和饲料成分，如鱼粉、昆虫粉和禽畜粉，以及富含PUFA的油，如海洋油、微生物油、真菌油、藻类油和富含PUFA的植物油。本发明还涉及含有式(I)的这种取代基氧杂环己烯-6-醇的饲料成分和用于昆虫、水生和陆生动物的饲料。
• Methods for treatment of dermatological conditions
  申请人：Wang Bing

  公开号：US20050032751A1

  公开（公告）日：2005-02-10

  A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.

  本文揭示了一种通过含有本文所述的任何Formulae I或Ia化合物的局部组合物来减少与皮肤松弛、皮肤紧致度或眼部黑眼圈相关的皮肤状况的方法。
• MULTI-STEP PROCESS FOR NO PRODUCTION
  申请人：BSN medical GmbH

  公开号：US20180116920A1

  公开（公告）日：2018-05-03

  The present invention relates to a multi-step process for the production of nitrogen monoxide (NO) from a pH-labile NO donor in the presence of at least one antioxidant. The invention also relates to a device for implementation of said process and the use of said device for the treatment of diseases. Moreover, the invention relates to a cosmetic process using said process or said device.

  本发明涉及一种多步骤过程，用于在存在至少一种抗氧化剂的情况下，从pH不稳定的NO供体中生产一氧化氮（NO）。该发明还涉及用于实施该过程的装置以及利用该装置用于治疗疾病的方法。此外，该发明还涉及使用该过程或该装置的化妆过程。
• Synthesis and antioxidant activity of 5-hydroxycoumarans, 6-hydroxychromanes and sulfur-containing derivatives on their base
  作者：S. E. Yagunov、S. V. Khol’shin、N. V. Kandalintseva、A. E. Prosenko

  DOI：10.1007/s11172-013-0200-4

  日期：2013.6

  A synthesis of 5-hydroxycoumarans, 6-hydroxychromanes and their dodecylthiomethylsubstituted derivatives was accomplished based on methylphenols through the intermediate preparation of 2-allyl-4-alkoxyphenols. The sulfur-containing compounds synthesized were shown to be highly efficient as inhibitors of autooxidation of methyl oleate.

  通过中间体2-丙烯基-4-烷氧基苯酚的制备，基于甲基酚成功合成了5-羟基香豆素、6-羟基克罗莫烯及其十二烷硫基甲基取代衍生物。合成的含硫化合物表现出作为甲基油酸自氧化抑制剂的高效性。