1H-Pyrazolo[3,4-b]pyridine-3-sulfonoyl chloride, 1,4,6-trimethyl- | 1159275-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 1H-Pyrazolo[3,4-b]pyridine-3-sulfonoyl chloride, 1,4,6-trimethyl-
• 英文别名: 1,4,6-trimethylpyrazolo[3,4-b]pyridine-3-sulfonyl chloride
• CAS: 1159275-11-2
• 化学式: C₉H₁₀ClN₃O₂S
• 分子量: 259.716
• InChiKey: LNTMZNJFPJQYQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1H-Pyrazolo[3,4-b]pyridine-3-sulfonoyl chloride, 1,4,6-trimethyl- 、 二烯丙基胺 在 三乙胺 作用下， 以 苯 为溶剂， 以72%的产率得到1,4,6-trimethyl-N,N-bis(prop-2-enyl)pyrazolo[3,4-b]pyridine-3-sulfonamide
  参考文献：
  名称：

  Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides

  摘要：

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.

  DOI：

  10.1007/s10593-009-0169-y
• 作为产物：
  描述：

  1,4,6-三甲基-3-氨基吡唑并[3,4-B]吡啶 在 盐酸 、 sodium nitrite 、 二氧化硫 、 copper(II) sulfate 作用下， 以 水 、 溶剂黄146 为溶剂， 以68%的产率得到1H-Pyrazolo[3,4-b]pyridine-3-sulfonoyl chloride, 1,4,6-trimethyl-
  参考文献：
  名称：

  Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides

  摘要：

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.

  DOI：

  10.1007/s10593-009-0169-y

文献信息

• Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides
  作者：I. G. Dmitrieva、L. V. Dyadyuchenko、V. D. Strelkov、E. A. Kaigorodova

  DOI：10.1007/s10593-009-0169-y

  日期：2008.10

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.