dl-α,β-Di-O-hexadecylglycerol bromohydrin | 92835-95-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dl-α,β-Di-O-hexadecylglycerol bromohydrin
• 英文别名: 2,3-bis(hexadecyloxy)propyl bromide；1-(3-Bromo-2-hexadecoxypropoxy)hexadecane
• CAS: 92835-95-5
• 化学式: C₃₅H₇₁BrO₂
• 分子量: 603.852
• InChiKey: RWPCAKZWQMVTJU-UHFFFAOYSA-N

物化性质

• 沸点：
  606.0±35.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  16.3
• 重原子数：
  38
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dl-α,β-Di-O-hexadecylglycerol bromohydrin 以 乙醇 为溶剂， 生成 Hexanediyl-α,ω-bis[dl-N-(1,2-di-O-hexadecyl-3-propyl)-N,N-dimethylammonium bromide]
  参考文献：
  名称：

  Synthesis and vesicle formation from novel pseudoglyceryl dimeric lipids. Evidence of formation of widely different membrane organizations with exceptional thermotropic properties

  摘要：

  合成了八种新的双阳离子二聚体脂质2a–h；对其水相分散液的透射电子显微镜（TEM）分析确认了囊泡的形成，通过热分析、光谱学、动态光散射（DLS）和X射线衍射（XRD）研究表明，它们根据m值形成三种不同类型的膜状聚集体。

  DOI：

  10.1039/a704154c
• 作为产物：
  描述：

  1,2-O-双十六烷基-rac-甘油 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到dl-α,β-Di-O-hexadecylglycerol bromohydrin
  参考文献：
  名称：

  Synthesis and vesicle formation from novel pseudoglyceryl dimeric lipids. Evidence of formation of widely different membrane organizations with exceptional thermotropic properties

  摘要：

  合成了八种新的双阳离子二聚体脂质2a–h；对其水相分散液的透射电子显微镜（TEM）分析确认了囊泡的形成，通过热分析、光谱学、动态光散射（DLS）和X射线衍射（XRD）研究表明，它们根据m值形成三种不同类型的膜状聚集体。

  DOI：

  10.1039/a704154c

文献信息

• 一种1,2-O-双十六烷基-rac-甘油的合成方法
  申请人：江苏省计量科学研究院

  公开号：CN105439827A

  公开（公告）日：2016-03-30

  本发明公开了一种1,2-O-双十六烷基-rac-甘油的合成方法，包括首先将甘油与丙酮搅拌混合，以对甲苯磺酸为催化剂合成丙酮缩甘油，然后将丙酮缩甘油C1位羟基用苄基保护得到1-苯甲基-2,3-异亚丙基-rac-甘油，再用一定浓度的盐酸脱保护，得到3-苄氧基-1,2-丙二醇，与溴代十六烷发生威廉姆逊反应得到1-O-苄基-2,3-O-二十六烷基甘油，最后在氢气钯碳作用下脱去苄基得到1,2-O-双十六烷基-rac-甘油。本发明提供了一种新的合成1,2-O-双十六烷基-rac-甘油的途径。
• Stabilization of nucleic acid amplification cocktails
  申请人：——

  公开号：US20020061537A1

  公开（公告）日：2002-05-23

  The present invention provides a cocktail of reagents for nucleic acid amplification that are stabilized by inclusion of a reversible inhibitor of undesirable reactions. Such cocktail of reagents eliminates the requirement for separate preparation and quality control of each reagent used in a reaction. Methods to prepare stabilized cocktails and to use stabilized cocktails also are included. The stabilized cocktail compositions also can include reagents to release nucleic acid from cells and to label the nucleic acid, allowing detection of nucleic acid in a sample with a single reagent addition step. The invention also provides kits for performing the above methods.

  本发明提供了一种核酸扩增试剂混合物，其通过包含可逆抑制剂来稳定，以防止不良反应的发生。这种试剂混合物消除了在反应中使用的每种试剂的单独制备和质量控制的要求。还包括制备稳定混合物和使用稳定混合物的方法。稳定的混合物组成还可以包括释放细胞中核酸和标记核酸的试剂，使得在样品中检测核酸只需要一个试剂添加步骤。本发明还提供了执行上述方法的试剂盒。
• Thiocationic lipids, pharmaceutical compositions and methods of use thereof
  申请人：GEN-PROBE INCORPORATED

  公开号：EP0747351A2

  公开（公告）日：1996-12-11

  Lipid molecules bearing a cationic charge are described. These cationic lipids are useful in the delivery of biomolecules, such as oligonucleotides, nucleic acids, peptides, diagnostic imaging agents, proteins and drug molecules. In the form of liposomes, they can effectively be used for the intracellular delivery of biomolecules for therapeutic or diagnostic purposes.

  本文描述了带有阳离子电荷的脂质分子。这些阳离子脂质可用于输送生物大分子，如寡核苷酸、核酸、肽、诊断成像剂、蛋白质和药物分子。以脂质体的形式，它们可有效地用于细胞内输送用于治疗或诊断目的的生物大分子。
• Synthesis and Vesicle Formation from Dimeric Pseudoglyceryl Lipids with (CH2)m Spacers: Pronounced m-Value Dependence of Thermal Properties, Vesicle Fusion, and Cholesterol Complexation
  作者：Santanu Bhattacharya、Soma De

  DOI：10.1002/(sici)1521-3765(19990802)5:8<2335::aid-chem2335>3.0.co;2-u

  日期：1999.8.2

  Eight new dimeric lipids, in which the two Me2N+ ion headgroups are separated by a variable number of polymethylene units [-(CH2)(m)-], have been synthesized. The electron micrograph (TEM) and dynamic light scattering (DLS) of their aqueous dispersions confirmed the formation of vesicular-type aggregates. The vesicle sizes and morphologies were found to depend strongly on the m value, the method, and thermal history of the vesicle preparation. Information on the thermotropic properties of the resulting vesicles was obtained from microcalorimetry and temperature-dependent fluorescence anisotropy measurements. Interestingly, the T-m values for these vesicles revealed a nonlinear dependence on spacer chain length (m value). These vesicles were able to entrap riboflavin. The rates of permeation of the OH- ion under an imposed transmembrane pH gradient were also found to depend significantly on the m value. X-Ray diffraction of the cast films of the lipid dispersions elucidated the nature and the thickness of these membrane organizations, and it was revealed that these lipids organize in three different ways depending on the m value. The EPR spin-probe method with the doxylstearic acids 5NS, 12NS, and 16NS, spin-labeled at various positions of stearic acid, was used to establish, the chain-flexibility gradient and homogeneity of these bilayer assemblies. The apparent fusogenic propensities of these bipolar tetraether lipids were investigated in the presence of Na2SO4 with fluorescence-resonance energy-transfer fusion assay. Small unilamellar vesicles formed from 1 and three representative biscationic lipids were also studied with fluorescence anisotropy and H-1 NMR spectroscopic techniques in the absence and the presence of varying amounts of cholesterol.
• US5711964A
  申请人：——

  公开号：US5711964A

  公开（公告）日：1998-01-27